Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4634-4641

  Kamiński, Krzysztof ^a   Obniska, Jolanta ^a   Wiklik, Beata ^a   Atamanyuk, Dmytro ^b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

4 Azatricyclo 5.2.1.0 2,6 dec 8 ene 3,5 dione; Anticonvulsant activity; Hexahydro 1H isoindole 1,3(2H) dione; In vivo studies; Phthalimide (isoindoline 1,3 dione)

Indexed keywords

(3,5 DIOXO 4 AZATRICYCLO [5.2.1.0 2,6]DEC 8 EN 4 YL)ACETIC ACID; 2 (1,3 DIOXO 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOL 2 YL)ACETIC ACID; 2 (1,3 DIOXOISOIN DOLIN 2 YL)ACETIC ACID; 2 [2 (MORPHOLIN 4 YL) 2 OXOETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 (MORPHOLIN 4 YL) 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE MONOHYDROCHLORIDE; 2 [2 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 [4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,6,7,7ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 [4 (BENZYLPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 3 ALPHA,4,5,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE MONOHYDROCHLORIDE; 2 [2 [4 (BENZYLPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHYL] 3 ALPHA,4,5,6,7,7 ALPHA HEXAHYDROISOINDOLE 1,3 DIONE; 2 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHYL]ISOINDOLINE 1,3 DIONE; ACETAMIDE DERIVATIVE; CARBAMAZEPINE; CYCLOHEXANE DERIVATIVE; ETHOSUXIMIDE; NORBORNENE DERIVATIVE; PHENYTOIN; PHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PROTECTION; RAT; ROTAROD TEST; SEIZURE;

ACETAMIDES; ANIMALS; ANTICONVULSANTS; BORON COMPOUNDS; CYCLOHEXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PHTHALIMIDES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80052943867     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.043     Document Type: Article

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