Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3768-3774

  Xu, Guang Fang ^a   Song, Bao An ^a   Bhadury, Pinaki S ^a   Yang, Song ^a   Zhang, Pei Quan ^a   Jin, Lin Hong ^a   Xue, Wei ^a   Hu, De Yu ^a   Lu, Ping ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Antifungal bioactivity; Fluorine moiety; Mechanism of action; Quinazoline; Thioether

Indexed keywords

2 (6 FLUOROQUINAZOLIN 4 YLTHIO) 1 (2,3,4 TRIMETHOXYPHENYL)ETHANONE; 4 (2 CHLORO 5 PYRIDYLMETHYLTHIO) 6 FLUOROQUINAZOLINE; 4 (2 ETHOXYCARBOXYLMETHYLENETHIO) 6 FLUOROQUINAZOLINE; 4 (4 CHLOROBENZYLTHIO) 6 FLUOROQUINAZOLINE; 4 ALLYLTHIO 6 FLUOROQUINAZOLINE; 4 BENZYLTHIO 6 FLUOROQUINAZOLINE; 4 ETHYLTHIO 6 FLUOROQUINAZOLINE; 4 N PROPYLTHIO 6 FLUOROQUINAZOLINE; BENZOIC ACID DERIVATIVE; CHITINASE; FORMAMIDE; HALIDE; HYDROXYL GROUP; PHOSPHORUS DERIVATIVE; PHOSPHORUS SULFIDE; QUINAZOLINE DERIVATIVE; SUGAR; THIOL; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYCLIZATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOSOME; ENZYME ACTIVITY; FUSARIUM OXYSPORUM; GROWTH INHIBITION; GROWTH RATE; IN VITRO STUDY; INFRARED SPECTROSCOPY; MYCELIAL GROWTH; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETYLGLUCOSAMINE; ANTIFUNGAL AGENTS; CELL MEMBRANE; CHITINASE; CHITOSAN; FUNGI; FUSARIUM; MAGNETIC RESONANCE SPECTROSCOPY; MYCELIUM; PERMEABILITY; QUINAZOLINES; SPECTROPHOTOMETRY, INFRARED; SULFHYDRYL COMPOUNDS;

FUNGI; FUSARIUM OXYSPORUM;

EID: 34247326968     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.037     Document Type: Article

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