-
1
-
-
46049092624
-
Evolution and taxonomic distribution of non-ribosomal peptide and polyketide synthases
-
Amoutzias GD, van de Peer Y, Mossialos D (2008) Evolution and taxonomic distribution of non-ribosomal peptide and polyketide synthases. Future Microbiol 3(3): 361-370.
-
(2008)
Future Microbiol
, vol.3
, Issue.3
, pp. 361-370
-
-
Amoutzias, G.D.1
van de Peer, Y.2
Mossialos, D.3
-
2
-
-
77954265333
-
SBSPKS: structure based sequence analysis of polyketide synthases
-
(Web Server issue)
-
Anand S, Prasad MV, Yadav G, Kumar N, Shehara J, Ansari MZ, Mohanty D (2010) SBSPKS: structure based sequence analysis of polyketide synthases. Nucleic Acids Res 38(Web Server issue): W487-W496.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Anand, S.1
Prasad, M.V.2
Yadav, G.3
Kumar, N.4
Shehara, J.5
Ansari, M.Z.6
Mohanty, D.7
-
3
-
-
33947308882
-
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
-
Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4): 213-217.
-
(2007)
Nat Chem Biol
, vol.3
, Issue.4
, pp. 213-217
-
-
Bergmann, S.1
Schümann, J.2
Scherlach, K.3
Lange, C.4
Brakhage, A.A.5
Hertweck, C.6
-
4
-
-
0037700977
-
Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites
-
Bode HB, Müller R (2003) Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites. Plant Physiol 132(3): 1153-1161.
-
(2003)
Plant Physiol
, vol.132
, Issue.3
, pp. 1153-1161
-
-
Bode, H.B.1
Müller, R.2
-
5
-
-
38549094609
-
NORINE: a database of non-ribosomal peptides
-
(Database issue)
-
Caboche S, Pupin M, Leclère V, Fontaine A, Jacques P, Kucherov G (2008) NORINE: a database of non-ribosomal peptides. Nucleic Acids Res 36(Database issue): D326-D331.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Caboche, S.1
Pupin, M.2
Leclère, V.3
Fontaine, A.4
Jacques, P.5
Kucherov, G.6
-
6
-
-
42949136443
-
Genome mining for novel natural product discovery
-
Challis GL (2008) Genome mining for novel natural product discovery. J Med Chem 51(9): 2618-2628.
-
(2008)
J Med Chem
, vol.51
, Issue.9
, pp. 2618-2628
-
-
Challis, G.L.1
-
7
-
-
0034659816
-
Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase
-
Challis GL, Ravel J (2000) Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase. FEMS Microbiol Lett 187(2): 111-114.
-
(2000)
FEMS Microbiol Lett
, vol.187
, Issue.2
, pp. 111-114
-
-
Challis, G.L.1
Ravel, J.2
-
8
-
-
45149124021
-
Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway
-
Chiang YM, Szewczyk E, Nayak T, Davidson AD, Sanchez JF, Lo HC, Ho WY, Simityan H, Kuo E, Praseuth A, Watanabe K, Oakley BR, Wang CC (2008) Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chem Biol 15(6): 527-532.
-
(2008)
Chem Biol
, vol.15
, Issue.6
, pp. 527-532
-
-
Chiang, Y.M.1
Szewczyk, E.2
Nayak, T.3
Davidson, A.D.4
Sanchez, J.F.5
Lo, H.C.6
Ho, W.Y.7
Simityan, H.8
Kuo, E.9
Praseuth, A.10
Watanabe, K.11
Oakley, B.R.12
Wang, C.C.13
-
9
-
-
77956727495
-
Recent progress and new challenges in metagenomics for biotechnology
-
Chistoserdova L (2010) Recent progress and new challenges in metagenomics for biotechnology. Biotechnol Lett 32(10): 1351-1359.
-
(2010)
Biotechnol Lett
, vol.32
, Issue.10
, pp. 1351-1359
-
-
Chistoserdova, L.1
-
10
-
-
33845708150
-
New antibiotics from bacterial natural products
-
Clardy J, Fischbach MA, Walsh CT (2006) New antibiotics from bacterial natural products. Nat Biotechnol 24(12): 1541-1550.
-
(2006)
Nat Biotechnol
, vol.24
, Issue.12
, pp. 1541-1550
-
-
Clardy, J.1
Fischbach, M.A.2
Walsh, C.T.3
-
11
-
-
84859643888
-
Structure guided approaches toward exploiting and manipulating non-ribosomal peptide and polyketide biosynthetic pathways
-
in press
-
Condurso HL, Bruner SD (2012) Structure guided approaches toward exploiting and manipulating non-ribosomal peptide and polyketide biosynthetic pathways. Curr Opin Chem Biol, in press.
-
(2012)
Curr Opin Chem Biol
-
-
Condurso, H.L.1
Bruner, S.D.2
-
12
-
-
77649206077
-
Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria
-
Craig JW, Chang FY, Kim JH, Obiajulu SC, Brady SF (2010) Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria. Appl Environ Microbiol 76(5): 1633-1641.
-
(2010)
Appl Environ Microbiol
, vol.76
, Issue.5
, pp. 1633-1641
-
-
Craig, J.W.1
Chang, F.Y.2
Kim, J.H.3
Obiajulu, S.C.4
Brady, S.F.5
-
13
-
-
0035487279
-
Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina
-
Davidson SK, Allen SW, Lim GE, Anderson CM, Haygood MG (2001) Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina. Appl Environ Microbiol 67(10): 4531-4537.
-
(2001)
Appl Environ Microbiol
, vol.67
, Issue.10
, pp. 4531-4537
-
-
Davidson, S.K.1
Allen, S.W.2
Lim, G.E.3
Anderson, C.M.4
Haygood, M.G.5
-
14
-
-
34848911303
-
Polyketide synthases and non-ribosomal peptide synthatases: the emerging view from bacterial genomics
-
Donadio S, Monciardini P, Sosio M (2007) Polyketide synthases and non-ribosomal peptide synthatases: the emerging view from bacterial genomics. Nat Prod Rep 24(5): 1073-1109.
-
(2007)
Nat Prod Rep
, vol.24
, Issue.5
, pp. 1073-1109
-
-
Donadio, S.1
Monciardini, P.2
Sosio, M.3
-
15
-
-
0034663771
-
An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003
-
Du L, Chen M, Sánchez C, Shen B (2000) An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003. FEMS Microbiol Lett 189(2): 171-175.
-
(2000)
FEMS Microbiol Lett
, vol.189
, Issue.2
, pp. 171-175
-
-
Du, L.1
Chen, M.2
Sánchez, C.3
Shen, B.4
-
16
-
-
0034796211
-
Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules
-
Du L, Sánchez C, Shen B (2001) Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules. Metab Eng 3(1): 78-95.
-
(2001)
Metab Eng
, vol.3
, Issue.1
, pp. 78-95
-
-
Du, L.1
Sánchez, C.2
Shen, B.3
-
17
-
-
84856403295
-
The great screen anomaly-a new frontier in product discovery through functional metagenomics
-
Ekkers DM, Cretoiu MS, Kielak AM, Elsas JD (2012) The great screen anomaly-a new frontier in product discovery through functional metagenomics. Appl Microbiol Biotechnol 93(3): 1005-1020.
-
(2012)
Appl Microbiol Biotechnol
, vol.93
, Issue.3
, pp. 1005-1020
-
-
Ekkers, D.M.1
Cretoiu, M.S.2
Kielak, A.M.3
Elsas, J.D.4
-
18
-
-
78650691813
-
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution
-
Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS (2011) The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. ChemBioChem 12(1): 61-64.
-
(2011)
ChemBioChem
, vol.12
, Issue.1
, pp. 61-64
-
-
Eustáquio, A.S.1
Nam, S.J.2
Penn, K.3
Lechner, A.4
Wilson, M.C.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
19
-
-
9244234513
-
Biosynthesis of non-ribosomal peptides
-
Finking R, Marahiel MA (2004) Biosynthesis of non-ribosomal peptides. Annu Rev Microbiol 58: 453-488.
-
(2004)
Annu Rev Microbiol
, vol.58
, pp. 453-488
-
-
Finking, R.1
Marahiel, M.A.2
-
20
-
-
0014289968
-
The activation of amino acids for biosynthesis of gramicidin S
-
Gevers W, Kleinkauf H, Lipmann F (1968) The activation of amino acids for biosynthesis of gramicidin S. Proc Natl Acad Sci USA 60(1): 269-276.
-
(1968)
Proc Natl Acad Sci USA
, vol.60
, Issue.1
, pp. 269-276
-
-
Gevers, W.1
Kleinkauf, H.2
Lipmann, F.3
-
21
-
-
79954503621
-
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage
-
Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH (2011) Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS ONE 6(4): e18565.
-
(2011)
PLoS ONE
, vol.6
, Issue.4
-
-
Grindberg, R.V.1
Ishoey, T.2
Brinza, D.3
Esquenazi, E.4
Coates, R.C.5
Liu, W.T.6
Gerwick, L.7
Dorrestein, P.C.8
Pevzner, P.9
Lasken, R.10
Gerwick, W.H.11
-
22
-
-
33846294440
-
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters
-
Gross H, Stockwell VO, Henkels MD, Nowak-Thompson B, Loper JE, Gerwick WH (2007) The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol 14(1): 53-63.
-
(2007)
Chem Biol
, vol.14
, Issue.1
, pp. 53-63
-
-
Gross, H.1
Stockwell, V.O.2
Henkels, M.D.3
Nowak-Thompson, B.4
Loper, J.E.5
Gerwick, W.H.6
-
23
-
-
8844270242
-
bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina
-
Hildebrand M, Waggoner LE, Liu H, Sudek S, Allen S, Anderson C, Sherman DH, Haygood M (2004) bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol 11(11): 1543-1552.
-
(2004)
Chem Biol
, vol.11
, Issue.11
, pp. 1543-1552
-
-
Hildebrand, M.1
Waggoner, L.E.2
Liu, H.3
Sudek, S.4
Allen, S.5
Anderson, C.6
Sherman, D.H.7
Haygood, M.8
-
24
-
-
70350736731
-
Polyketide synthases of bacterial symbionts in sponges-evolution-based applications in natural products research
-
Hochmuth T, Piel J (2009) Polyketide synthases of bacterial symbionts in sponges-evolution-based applications in natural products research. Phytochemistry 70(15-16): 1841-1849.
-
(2009)
Phytochemistry
, vol.70
, Issue.15-16
, pp. 1841-1849
-
-
Hochmuth, T.1
Piel, J.2
-
25
-
-
79958005979
-
Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517
-
Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z (2011) Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem 286(23): 20648-20657.
-
(2011)
J Biol Chem
, vol.286
, Issue.23
, pp. 20648-20657
-
-
Huang, T.1
Wang, Y.2
Yin, J.3
Du, Y.4
Tao, M.5
Xu, J.6
Chen, W.7
Lin, S.8
Deng, Z.9
-
26
-
-
34248579751
-
Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety
-
Ishida K, Christiansen G, Yoshida WY, Kurmayer R, Welker M, Valls N, Bonjoch J, Hertweck C, Börner T, Hemscheidt T, Dittmann E (2007) Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chem Biol 14(5): 565-576.
-
(2007)
Chem Biol
, vol.14
, Issue.5
, pp. 565-576
-
-
Ishida, K.1
Christiansen, G.2
Yoshida, W.Y.3
Kurmayer, R.4
Welker, M.5
Valls, N.6
Bonjoch, J.7
Hertweck, C.8
Börner, T.9
Hemscheidt, T.10
Dittmann, E.11
-
27
-
-
63849226090
-
Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria
-
Ishida K, Welker M, Christiansen G, Cadel-Six S, Bouchier C, Dittmann E, Hertweck C, Tandeau de Marsac N (2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol 75(7): 2017-2026.
-
(2009)
Appl Environ Microbiol
, vol.75
, Issue.7
, pp. 2017-2026
-
-
Ishida, K.1
Welker, M.2
Christiansen, G.3
Cadel-Six, S.4
Bouchier, C.5
Dittmann, E.6
Hertweck, C.7
Tandeau de Marsac, N.8
-
28
-
-
70349231218
-
Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges
-
Jenke-Kodama H, Dittmann E (2009a) Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges. Nat Prod Rep 26(7): 874-883.
-
(2009)
Nat Prod Rep
, vol.26
, Issue.7
, pp. 874-883
-
-
Jenke-Kodama, H.1
Dittmann, E.2
-
29
-
-
70350708768
-
Evolution of metabolic diversity: Insights from microbial polyketide synthases
-
Jenke-Kodama H, Dittmann E (2009b) Evolution of metabolic diversity: Insights from microbial polyketide synthases. Phytochemistry 70(15-16): 1858-1866.
-
(2009)
Phytochemistry
, vol.70
, Issue.15-16
, pp. 1858-1866
-
-
Jenke-Kodama, H.1
Dittmann, E.2
-
30
-
-
24744433982
-
Evolutionary implications of bacterial polyketide synthases
-
Jenke-Kodama H, Sandmann A, Müller R, Dittmann E (2005) Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol 22(10): 2027-2039.
-
(2005)
Mol Biol Evol
, vol.22
, Issue.10
, pp. 2027-2039
-
-
Jenke-Kodama, H.1
Sandmann, A.2
Müller, R.3
Dittmann, E.4
-
31
-
-
33750428183
-
Natural biocombinatorics in the polyketide synthase enes of the actinobacterium Streptomyces avermitilis
-
Jenke-Kodama H, Börner T, Dittmann E (2006) Natural biocombinatorics in the polyketide synthase enes of the actinobacterium Streptomyces avermitilis. PLoS Comput Biol 2(10): e132.
-
(2006)
PLoS Comput Biol
, vol.2
, Issue.10
-
-
Jenke-Kodama, H.1
Börner, T.2
Dittmann, E.3
-
32
-
-
77952529863
-
Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism
-
Kennedy J, Flemer B, Jackson SA, Lejon DP, Morrissey JP, O'Gara F et al (2010) Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism. Mar Drugs 8(3): 608-628.
-
(2010)
Mar Drugs
, vol.8
, Issue.3
, pp. 608-628
-
-
Kennedy, J.1
Flemer, B.2
Jackson, S.A.3
Lejon, D.P.4
Morrissey, J.P.5
O'Gara, F.6
-
33
-
-
34547119075
-
Macrocyclization strategies in polyketide and non-ribosomal peptide biosynthesis
-
Kopp F, Marahiel MA (2007) Macrocyclization strategies in polyketide and non-ribosomal peptide biosynthesis. Nat Prod Rep 24(4): 735-749.
-
(2007)
Nat Prod Rep
, vol.24
, Issue.4
, pp. 735-749
-
-
Kopp, F.1
Marahiel, M.A.2
-
34
-
-
27544477567
-
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
-
Lautru S, Deeth RJ, Bailey LM, Challis GL (2005) Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol 1(5): 265-269.
-
(2005)
Nat Chem Biol
, vol.1
, Issue.5
, pp. 265-269
-
-
Lautru, S.1
Deeth, R.J.2
Bailey, L.M.3
Challis, G.L.4
-
35
-
-
0027250118
-
Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides
-
Lawen A, Traber R (1993) Lawen A, Traber R (1993) Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides. J Biol Chem 268(27): 20452-65. J Biol Chem 268(27): 20452-20465.
-
(1993)
J Biol Chem
, vol.268
, Issue.27
, pp. 20452-20465
-
-
Lawen, A.1
Traber, R.2
-
36
-
-
78650526727
-
Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus
-
Li B, Walsh CT (2010) Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus. Proc Natl Acad Sci USA 107(46): 19731-19735.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.46
, pp. 19731-19735
-
-
Li, B.1
Walsh, C.T.2
-
37
-
-
75549086416
-
The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata
-
(Database issue)
-
Liolios K, Chen IM, Mavromatis K, Tavernarakis N, Hugenholtz P, Markowitz VM, Kyrpides NC (2010) The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res 38(Database issue): D346-D354.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Liolios, K.1
Chen, I.M.2
Mavromatis, K.3
Tavernarakis, N.4
Hugenholtz, P.5
Markowitz, V.M.6
Kyrpides, N.C.7
-
38
-
-
80052078373
-
Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans
-
Liu T, Chiang YM, Somoza AD, Oakley BR, Wang CC (2011) Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc 133(34): 13314-13316.
-
(2011)
J Am Chem Soc
, vol.133
, Issue.34
, pp. 13314-13316
-
-
Liu, T.1
Chiang, Y.M.2
Somoza, A.D.3
Oakley, B.R.4
Wang, C.C.5
-
39
-
-
44249127964
-
Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy
-
Loper JE, Henkels MD, Shaffer BT, Valeriote FA, Gross H (2008) Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy. Appl Environ Microbiol 74(10): 3085-3093.
-
(2008)
Appl Environ Microbiol
, vol.74
, Issue.10
, pp. 3085-3093
-
-
Loper, J.E.1
Henkels, M.D.2
Shaffer, B.T.3
Valeriote, F.A.4
Gross, H.5
-
40
-
-
79959920872
-
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
-
(Web Server issue)
-
Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R (2011) antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 39(Web Server issue): W339-W346.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Medema, M.H.1
Blin, K.2
Cimermancic, P.3
de Jager, V.4
Zakrzewski, P.5
Fischbach, M.A.6
Weber, T.7
Takano, E.8
Breitling, R.9
-
41
-
-
53549118607
-
The metagenomics RAST server-a public resource for the automatic phylogenetic and functional analysis of metagenomes
-
Meyer F, Paarmann D, D'Souza M, Olson R, Glass EM, Kubal M et al (2008) The metagenomics RAST server-a public resource for the automatic phylogenetic and functional analysis of metagenomes. BMC Bioinformatics 9: 386.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 386
-
-
Meyer, F.1
Paarmann, D.2
D'Souza, M.3
Olson, R.4
Glass, E.M.5
Kubal, M.6
-
42
-
-
77957079227
-
Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and non-ribosomal peptide synthesis
-
Mocibob M, Ivic N, Bilokapic S, Maier T, Luic M, Ban N, Weygand-Durasevic I (2010) Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and non-ribosomal peptide synthesis. Proc Natl Acad Sci USA 107(33): 14585-14590.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.33
, pp. 14585-14590
-
-
Mocibob, M.1
Ivic, N.2
Bilokapic, S.3
Maier, T.4
Luic, M.5
Ban, N.6
Weygand-Durasevic, I.7
-
43
-
-
67349208005
-
A new approach to retrieve full lengths of functional genes from soil by PCR-DGGE and metagenome walking
-
Morimoto S, Fujii T (2009) A new approach to retrieve full lengths of functional genes from soil by PCR-DGGE and metagenome walking. Appl Microbiol Biotechnol 83(2): 389-396.
-
(2009)
Appl Microbiol Biotechnol
, vol.83
, Issue.2
, pp. 389-396
-
-
Morimoto, S.1
Fujii, T.2
-
44
-
-
80052637001
-
Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria
-
doi:10.1111/j.1574-6941.2011.01122.x
-
Parsley LC, Linneman J, Goode AM, Becklund K, George I, Goodman RM, Lopanik NB, Liles MR (2011) Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria. FEMS Microbiol Ecol 78(1): 176-187. doi: 10. 1111/j. 1574-6941. 2011. 01122. x.
-
(2011)
FEMS Microbiol Ecol
, vol.78
, Issue.1
, pp. 176-187
-
-
Parsley, L.C.1
Linneman, J.2
Goode, A.M.3
Becklund, K.4
George, I.5
Goodman, R.M.6
Lopanik, N.B.7
Liles, M.R.8
-
45
-
-
0037195174
-
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
-
Piel J (2002) A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proc Natl Acad Sci USA 99(22): 14002-14007.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.22
, pp. 14002-14007
-
-
Piel, J.1
-
46
-
-
9244230571
-
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
-
Piel J, Hui D, Wen G, Butzke D, Platzer M, Fusetani N, Matsunaga S (2004) Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei. Proc Natl Acad Sci USA 101(46): 16222-16227.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.46
, pp. 16222-16227
-
-
Piel, J.1
Hui, D.2
Wen, G.3
Butzke, D.4
Platzer, M.5
Fusetani, N.6
Matsunaga, S.7
-
47
-
-
17444392475
-
Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family
-
Piel J, Butzke D, Fusetani N, Hui D, Platzer M, Wen G, Matsunaga S (2005) Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family. J Nat Prod 68(3): 472-479.
-
(2005)
J Nat Prod
, vol.68
, Issue.3
, pp. 472-479
-
-
Piel, J.1
Butzke, D.2
Fusetani, N.3
Hui, D.4
Platzer, M.5
Wen, G.6
Matsunaga, S.7
-
48
-
-
0347635514
-
Phylogenetic evidence for the early evolution of microcystin synthesis
-
Rantala A, Fewer DP, Hisbergues M, Rouhiainen L, Vaitomaa J, Börner T, Sivonen K (2004) Phylogenetic evidence for the early evolution of microcystin synthesis. Proc Natl Acad Sci USA 101(2): 568-573.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.2
, pp. 568-573
-
-
Rantala, A.1
Fewer, D.P.2
Hisbergues, M.3
Rouhiainen, L.4
Vaitomaa, J.5
Börner, T.6
Sivonen, K.7
-
49
-
-
79959744432
-
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp
-
Rateb ME, Houssen WE, Arnold M, Abdelrahman MH, Deng H, Harrison WT, Okoro CK, Asenjo JA, Andrews BA, Ferguson G, Bull AT, Goodfellow M, Ebel R, Jaspars M (2011) Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp. J Nat Prod 74(6): 1491-1499.
-
(2011)
J Nat Prod
, vol.74
, Issue.6
, pp. 1491-1499
-
-
Rateb, M.E.1
Houssen, W.E.2
Arnold, M.3
Abdelrahman, M.H.4
Deng, H.5
Harrison, W.T.6
Okoro, C.K.7
Asenjo, J.A.8
Andrews, B.A.9
Ferguson, G.10
Bull, A.T.11
Goodfellow, M.12
Ebel, R.13
Jaspars, M.14
-
50
-
-
4344587758
-
Uncultured soil bacteria are a reservoir of new antibiotic resistance genes
-
Riesenfeld CS, Goodman RM, Handelsman J (2004) Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. Environ Microbiol 6(9): 981-989.
-
(2004)
Environ Microbiol
, vol.6
, Issue.9
, pp. 981-989
-
-
Riesenfeld, C.S.1
Goodman, R.M.2
Handelsman, J.3
-
51
-
-
0343371621
-
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
-
Rowe CJ, Böhm IU, Thomas IP, Wilkinson B, Rudd BA, Foster G, Blackaby AP, Sidebottom PJ, Roddis Y, Buss AD, Staunton J, Leadlay PF (2001) Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chem Biol 8(5): 475-485.
-
(2001)
Chem Biol
, vol.8
, Issue.5
, pp. 475-485
-
-
Rowe, C.J.1
Böhm, I.U.2
Thomas, I.P.3
Wilkinson, B.4
Rudd, B.A.5
Foster, G.6
Blackaby, A.P.7
Sidebottom, P.J.8
Roddis, Y.9
Buss, A.D.10
Staunton, J.11
Leadlay, P.F.12
-
52
-
-
34250639490
-
Metagenomics, biotechnology with non-culturable microbes
-
Schmeisser C, Steele H, Streit WR (2007) Metagenomics, biotechnology with non-culturable microbes. Appl Microbiol Biotechnol 75(5): 955-962.
-
(2007)
Appl Microbiol Biotechnol
, vol.75
, Issue.5
, pp. 955-962
-
-
Schmeisser, C.1
Steele, H.2
Streit, W.R.3
-
53
-
-
84555190775
-
Insights into antibiotic resistance through metagenomic approaches
-
Schmieder R, Edwards R (2012) Insights into antibiotic resistance through metagenomic approaches. Future Microbiol 7(1): 73-89.
-
(2012)
Future Microbiol
, vol.7
, Issue.1
, pp. 73-89
-
-
Schmieder, R.1
Edwards, R.2
-
54
-
-
0035023450
-
Multimodular biocatalysts for natural product assembly
-
Schwarzer D, Marahiel MA (2001) Multimodular biocatalysts for natural product assembly. Naturwissenschaften 88(3): 93-101.
-
(2001)
Naturwissenschaften
, vol.88
, Issue.3
, pp. 93-101
-
-
Schwarzer, D.1
Marahiel, M.A.2
-
55
-
-
71349088748
-
Achievements and new knowledge unraveled by metagenomic approaches
-
Simon C, Daniel R (2009) Achievements and new knowledge unraveled by metagenomic approaches. Appl Microbiol Biotechnol 85(2): 265-276.
-
(2009)
Appl Microbiol Biotechnol
, vol.85
, Issue.2
, pp. 265-276
-
-
Simon, C.1
Daniel, R.2
-
57
-
-
79151477225
-
Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi
-
Slot JC, Rokas A (2011) Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi. Curr Biol 21(2): 134-139.
-
(2011)
Curr Biol
, vol.21
, Issue.2
, pp. 134-139
-
-
Slot, J.C.1
Rokas, A.2
-
58
-
-
0034673983
-
Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase
-
Stachelhaus T, Walsh CT (2000) Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase. Biochemistry 39(19): 5775-5787.
-
(2000)
Biochemistry
, vol.39
, Issue.19
, pp. 5775-5787
-
-
Stachelhaus, T.1
Walsh, C.T.2
-
59
-
-
77951294519
-
Non-ribosomal peptide synthetases:Structures and dynamics
-
Strieker M, Tanovic A, Marahiel MA (2010) Strieker M, Tanovic A, Marahiel MA (2010) non-ribosomal peptide synthetases: Structures and dynamics. Curr Opin Struct Biol 20(2): 234-40. Curr Opin Struct Biol 20(2): 234-240.
-
(2010)
Curr Opin Struct Biol
, vol.20
, Issue.2
, pp. 234-240
-
-
Strieker, M.1
Tanovic, A.2
Marahiel, M.A.3
-
60
-
-
33646007621
-
Polyketide chain skipping mechanism in the biosynthesis of the hybrid non-ribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140
-
Tang GL, Cheng YQ, Shen B (2006) Polyketide chain skipping mechanism in the biosynthesis of the hybrid non-ribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. J Nat Prod 69(3): 387-393.
-
(2006)
J Nat Prod
, vol.69
, Issue.3
, pp. 387-393
-
-
Tang, G.L.1
Cheng, Y.Q.2
Shen, B.3
-
61
-
-
48749083335
-
Crystal structure of the termination module of a non-ribosomal peptide synthetase
-
Tanovic A, Samel SA, Essen LO, Marahiel MA (2008) Crystal structure of the termination module of a non-ribosomal peptide synthetase. Science 321(5889): 659-663.
-
(2008)
Science
, vol.321
, Issue.5889
, pp. 659-663
-
-
Tanovic, A.1
Samel, S.A.2
Essen, L.O.3
Marahiel, M.A.4
-
62
-
-
0035989968
-
Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer
-
Thomas I, Martin CJ, Wilkinson CJ, Staunton J, Leadlay PF (2002) Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer. Chem Biol 9(7): 781-787.
-
(2002)
Chem Biol
, vol.9
, Issue.7
, pp. 781-787
-
-
Thomas, I.1
Martin, C.J.2
Wilkinson, C.J.3
Staunton, J.4
Leadlay, P.F.5
-
63
-
-
0034648798
-
Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase
-
Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT (2000) Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase. Nature 407(6801): 215-218.
-
(2000)
Nature
, vol.407
, Issue.6801
, pp. 215-218
-
-
Trauger, J.W.1
Kohli, R.M.2
Mootz, H.D.3
Marahiel, M.A.4
Walsh, C.T.5
-
64
-
-
70449727646
-
Functional metagenomics for enzyme discovery: challenges to efficient screening
-
Uchiyama T, Miyazaki K (2009) Functional metagenomics for enzyme discovery: challenges to efficient screening. Curr Opin Biotechnol 20(6): 616-622.
-
(2009)
Curr Opin Biotechnol
, vol.20
, Issue.6
, pp. 616-622
-
-
Uchiyama, T.1
Miyazaki, K.2
-
65
-
-
34447302758
-
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
-
Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS (2007) Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci USA 104(25): 10376-10381.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.25
, pp. 10376-10381
-
-
Udwary, D.W.1
Zeigler, L.2
Asolkar, R.N.3
Singan, V.4
Lapidus, A.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
66
-
-
79960917265
-
Structure and genetics of circular bacteriocins
-
doi:10.1016/j.tim.2011.04.004
-
van Belkum MJ, Martin-Visscher LA, Vederas JC (2011) Structure and genetics of circular bacteriocins. Trends Microbiol 19(8): 411-418. doi: 10. 1016/j. tim. 2011. 04. 004.
-
(2011)
Trends Microbiol
, vol.19
, Issue.8
, pp. 411-418
-
-
van Belkum, M.J.1
Martin-Visscher, L.A.2
Vederas, J.C.3
-
67
-
-
14744277927
-
Biochemistry and general genetics of non-ribosomal peptide synthetases in fungi
-
von Döhren H (2004) Biochemistry and general genetics of non-ribosomal peptide synthetases in fungi. Adv Biochem Eng Biotechnol 88: 217-264.
-
(2004)
Adv Biochem Eng Biotechnol
, vol.88
, pp. 217-264
-
-
von Döhren, H.1
-
68
-
-
38949083855
-
The chemical versatility of natural-product assembly lines
-
Walsh CT (2008) The chemical versatility of natural-product assembly lines. Acc Chem Res 41(1): 4-10.
-
(2008)
Acc Chem Res
, vol.41
, Issue.1
, pp. 4-10
-
-
Walsh, C.T.1
-
69
-
-
79960251826
-
Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes
-
Wang Y, Chen Y, Shen Q, Yin X (2011) Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes. Gene 483(1-2): 11-21.
-
(2011)
Gene
, vol.483
, Issue.1-2
, pp. 11-21
-
-
Wang, Y.1
Chen, Y.2
Shen, Q.3
Yin, X.4
-
70
-
-
33744965454
-
Cyanobacterial peptides-nature's own combinatorial biosynthesis
-
Welker M, von Döhren H (2006) Cyanobacterial peptides-nature's own combinatorial biosynthesis. FEMS Microbiol Rev 30(4): 530-563.
-
(2006)
FEMS Microbiol Rev
, vol.30
, Issue.4
, pp. 530-563
-
-
Welker, M.1
von Döhren, H.2
-
71
-
-
15744396410
-
Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterativebacterial type I polyketide synthase and for module skipping in non-ribosomal peptide biosynthesis
-
Wenzel SC, Kunze B, Höfle G, Silakowski B, Scharfe M, Blöcker H, Müller R (2005) Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterativebacterial type I polyketide synthase and for module skipping in non-ribosomal peptide biosynthesis. ChemBioChem 6(2): 375-385.
-
(2005)
ChemBioChem
, vol.6
, Issue.2
, pp. 375-385
-
-
Wenzel, S.C.1
Kunze, B.2
Höfle, G.3
Silakowski, B.4
Scharfe, M.5
Blöcker, H.6
Müller, R.7
-
72
-
-
33746320424
-
Non-ribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversity
-
Wenzel SC, Meiser P, Binz TM, Mahmud T, Müller R (2006) Non-ribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversity. Angew Chem Int Ed Engl 45(14): 2296-2301.
-
(2006)
Angew Chem Int Ed Engl
, vol.45
, Issue.14
, pp. 2296-2301
-
-
Wenzel, S.C.1
Meiser, P.2
Binz, T.M.3
Mahmud, T.4
Müller, R.5
-
73
-
-
84859643086
-
Combinatorial biosynthesis of polyketides-a perspective
-
in press
-
Wong FT, Khosla C (2012) Combinatorial biosynthesis of polyketides-a perspective. Curr Opin Chem Biol, in press.
-
(2012)
Curr Opin Chem Biol
-
-
Wong, F.T.1
Khosla, C.2
-
74
-
-
58649098990
-
Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation
-
Yin WB, Grundmann A, Cheng J, Li SM (2009) Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem 284(1): 100-109.
-
(2009)
J Biol Chem
, vol.284
, Issue.1
, pp. 100-109
-
-
Yin, W.B.1
Grundmann, A.2
Cheng, J.3
Li, S.M.4
-
75
-
-
0029143685
-
Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase
-
Yu JH, Leonard TJ (1995) Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. J Bacteriol 177(16): 4792-4800.
-
(1995)
J Bacteriol
, vol.177
, Issue.16
, pp. 4792-4800
-
-
Yu, J.H.1
Leonard, T.J.2
-
76
-
-
65549083361
-
Strategies for the discovery of new natural products by genome mining
-
Zerikly M, Challis GL (2009) Strategies for the discovery of new natural products by genome mining. ChemBioChem 10(4): 625-633.
-
(2009)
ChemBioChem
, vol.10
, Issue.4
, pp. 625-633
-
-
Zerikly, M.1
Challis, G.L.2
-
77
-
-
79961045257
-
tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics
-
Zhang W, Ntai I, Kelleher NL, Walsh CT (2011) tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics. Proc Natl Acad Sci USA 108(30): 12249-12253.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.30
, pp. 12249-12253
-
-
Zhang, W.1
Ntai, I.2
Kelleher, N.L.3
Walsh, C.T.4
|