Soluble triggering receptor expressed on myeloid cells-1 as a new therapeutic molecule in rheumatoid arthritis

Medical Hypotheses

Volumn 78, Issue 2, 2012, Pages 270-272

  Kim, Tae Hwan ^a   Choi, Sung Jae ^b   Lee, Young Ho ^b   Song, Gwan Gyu ^b   Ji, Jong Dae ^b  

^a Hanyang University   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; DRUG TARGETING; HUMAN; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; HUMANS; IMMUNOGLOBULIN G; INFLAMMATION; LIGANDS; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS;

EID: 84855189262     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.10.042     Document Type: Article

References (26)

1. Brennan F.M., McInnes I.B. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 2008, 118:3537-3545.
2. Smolen J.S., Aletaha D., Koeller M., Weisman M.H., Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 2007, 370:1861-1874.
3. Buch M.H. Sequential use of biologic therapy in rheumatoid arthritis. Curr Opin Rheumatol 2010, 22:321-329.
4. Caporali R., Pallavicini F.B., Filippini M., Gorla R., Marchesoni A., Favalli E.G., et al. Treatment of rheumatoid arthritis with anti-TNF-alpha agents: a reappraisal. Autoimmun Rev 2009, 8:274-280.
5. Derive M., Massin F., Gibot S. Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases. Self Nonself 2010, 1:225-230.
6. Klesney-Tait J., Turnbull I.R., Colonna M. The TREM receptor family and signal integration. Nat Immunol 2006, 7:1266-1273.
7. Tessarz A.S., Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett 2008, 116:111-116.
8. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003, 3:445-453.
9. Sharif O., Knapp S. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 2008, 213:701-713.
10. Bleharski J.R., Kiessler V., Buonsanti C., Sieling P.A., Stenger S., Colonna M., et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol 2003, 170:3812-3818.
11. Bouchon A., Dietrich J., Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164:4991-4995.
12. Bouchon A., Facchetti F., Weigand M.A., Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001, 410:1103-1107.
13. Ornatowska M., Azim A.C., Wang X., Christman J.W., Xiao L., Joo M., et al. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol 2007, 293:L1377-1384.
14. Collins C.E., La D.T., Yang H.T., Massin F., Gibot S., Faure G., et al. Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis. Ann Rheum Dis 2009, 68:1768-1774.
15. Kuai J., Gregory B., Hill A., Pittman D.D., Feldman J.L., Brown T., et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford) 2009, 48:1352-1358.
16. Murakami Y., Akahoshi T., Aoki N., Toyomoto M., Miyasaka N., Kohsaka H. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum 2009, 60:1615-1623.
17. Murakami Y., Akahoshi T., Hayashi I., Endo H., Kawai S., Inoue M., et al. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Arthritis Rheum 2006, 54:455-462.
18. Schenk M., Bouchon A., Seibold F., Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 2007, 117:3097-3106.
19. Wang D.Y., Qin R.Y., Liu Z.R., Gupta M.K., Chang Q. Expression of TREM-1 mRNA in acute pancreatitis. World J Gastroenterol 2004, 10:2744-2746.
20. Gibot S., Kolopp-Sarda M.N., Bene M.C., Bollaert P.E., Lozniewski A., Mory F., et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med 2004, 200:1419-1426.
21. Gibot S., Alauzet C., Massin F., Sennoune N., Faure G.C., Bene M.C., et al. Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats. J Infect Dis 2006, 194:975-983.
22. Wiersinga W.J., Veer C.T., Wieland C.W., Gibot S., Hooibrink B., Day N.P., et al. Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. J Infect Dis 2007, 196:1707-1716.
23. Gomez-Pina V., Soares-Schanoski A., Rodriguez-Rojas A., Del Fresno C., Garcia F., Vallejo-Cremades M.T., et al. Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol 2007, 179:4065-4073.
24. Haselmayer P., Grosse-Hovest L., von Landenberg P., Schild H., Radsak M.P. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 2007, 110:1029-1035.
25. Fernandez-Botran R., Crespo F.A., Sun X. Soluble cytokine receptors in biological therapy. Expert Opin Biol Ther 2002, 2:585-605.
26. Edwards C.K. PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases. Ann Rheum Dis 1999, 58:I73-81.