Micro RNA responses to chronic or acute exposures to low dose ionizing radiation

Molecular Biology Reports

Volumn 39, Issue 7, 2012, Pages 7549-7558

  Chaudhry, M Ahmad ^a   Omaruddin, Romaica A ^a   Kreger, Bridget ^a   De Toledo, Sonia M ^b   Azzam, Edouard I ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Gene expression; Low dose ionizing radiation; Micro RNA; Radiation effects

Indexed keywords

ALPHA TROPOMYOSIN; MICRORNA; MICRORNA 142 3P; MICRORNA 142 5P; MICRORNA 143; MICRORNA 145; MICRORNA 155; MICRORNA 15A; MICRORNA 16; MICRORNA 17 3P; MICRORNA 17 5P; MICRORNA 18A; MICRORNA 19A; MICRORNA 19B; MICRORNA 21; MICRORNA LET 7B; MICRORNA LET 7C; MICRORNA LET 7D; MICRORNA LET 7E; MICRORNA LET 7F; MICRORNA LET 7I; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGRAMMED CELL DEATH FACTOR 4; PROTEIN; SPROUTY HOMOLOG 2; UNCLASSIFIED DRUG;

ACUTE EXPOSURE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXPOSURE; GAMMA RADIATION; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEALTH HAZARD; HUMAN; HUMAN CELL; IONIZING RADIATION; LONG TERM EXPOSURE; ONCOGENE C MYC; ONCOGENE RAS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; UPREGULATION;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; RADIATION DOSAGE; SKIN; TRANSCRIPTIONAL ACTIVATION;

EID: 84864288293     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1589-9     Document Type: Article

References (56)

1. Preston RJ (2003) The LNT model is the best we can do-today. J Radiol Prot 23(3):263-268 (Pubitemid 37254165)
2. Little MP, Muirhead CR (2000) Derivation of low-dose extrapolation factors from analysis of curvature in the cancer incidence dose response in Japanese atomic bomb survivors. Int J Radiat Biol 76(7):939-953 (Pubitemid 30446957)
3. Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of micro-rna in human cells differing in radiation sensitivity. Int J Radiat Biol 86(7):569-583
4. Tubiana M, Aurengo A, Averbeck D, Masse R (2006) Recent reports on the effect of low doses of ionizing radiation and its dose-effect relationship. Radiat Environ Biophys 44(4):245-251 (Pubitemid 43326057)
5. Averbeck D (2010) Non-targeted effects as a paradigm breaking evidence. Mutat Res 687(1-2):7-12
6. Huang L, Kim PM, Nickoloff JA, Morgan WF (2007) Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells. Cancer Res 67(3):1099-1104
7. Murnane JP, Sabatier L (2004) Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays 26(11):1164-1174 (Pubitemid 39536612)
8. Wolff S (1998) The adaptive response in radiobiology: evolving insights and implications. Environ Health Perspect 106(Suppl 1):277-283
9. Azzam EI, Little JB (2004) The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol 23(2):61-65 (Pubitemid 38380014)
10. Rigaud O, Moustacchi E (1996) Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutat Res 358(2):127-134 (Pubitemid 26384282)
11. de Toledo SM, Azzam EI (2006) Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: the impact of linear energy transfer. Dose Response 4(4):291-301
12. deToledo SM, Asaad N, Venkatachalam P, Li L, Howell RW, Spitz DR, Azzam EI (2006) Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiat Res 166(6): 849-857 (Pubitemid 44888250)
13. Gaillard S, Pusset D, de Toledo SM, Fromm M, Azzam EI (2009) Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication. Radiat Res 171(5):513-520
14. Spitz DR, Azzam EI, Li JJ, Gius D (2004) Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23(3-4):311-322 (Pubitemid 38881814)
15. Bartel DP (2004) Micrornas: genomics, biogenesis, mechanism, and function. Cell 116(2):281-297
16. Yekta S, Shih IH, Bartel DP (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304(5670):594-596 (Pubitemid 38541919)
17. Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W (2005) Inhibition of trans-lational initiation by Let-7 MicroRNA in human cells. Science 309(5740):1573-1576 (Pubitemid 41266485)
18. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433(7027):769-773 (Pubitemid 40292988)
19. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS (2004) Human MicroRNA targets. PLoS Biol 2(11):e363
20. Chaudhry MA (2009) Real-time PCR analysis of micro-RNA expression in ionizing radiation-treated cells. Cancer Biother Radiopharm 24(1):49-56
21. Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86:569-583
22. Chaudhry MA, Sachdeva H, Omaruddin RA (2010) Radiation-induced Micro-RNA modulation in glioblastoma cells differing in DNA-repair pathways. DNA Cell Biol 29(9):553-561
23. Goddu SM, Howell RW, Rao DV (2001) Method and means for variably attenuating radiation. United States Patent US 6, 201, 852 B1
24. Howell RW, Goddu SM, Rao DV (1997) Design and performance characteristics of an experimental Cs-137 irradiator to simulate internal radionuclide dose rate patterns. J Nucl Med 38:727-731 (Pubitemid 127777346)
25. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) Method. Methods 25(4):402-408 (Pubitemid 34164012)
26. Bagley J, Rosenzweig M, Marks DF, Pykett MJ (1999) Extended culture of multipotent hematopoietic progenitors without cyto-kine augmentation in a novel three-dimensional device. Exp Hematol 27(3):496-504 (Pubitemid 29125058)
27. Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT (2000) Efficient generation of human T cells from a tissue-engineered thymic orga-noid. Nat Biotechnol 18(7):729-734 (Pubitemid 30460687)
28. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120(5):635-647 (Pubitemid 40343076)
29. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T (2004) Reduced expression of the let-7 microR-NAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64(11):3753-3756 (Pubitemid 38697282)
30. Goodsell DS (1999) The molecular perspective: the ras oncogene. Oncologist 4(3):263-264 (Pubitemid 29297488)
31. Yaguang Xi JRE, Jingfang Ju (2007) Investigation of miRNA Biology by bioinformatic tools and impact of miRNAs in colo-rectal cancer-regulatory relationship of c-Myc and p53 with miRNAs. Cancer Inform 3:245-253
32. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM (2005) A microRNA polycistron as a potential human oncogene. Nature 435(7043):828-833 (Pubitemid 40839734)
33. Pelengaris S, Khan M, Evan GI (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109(3):321-334 (Pubitemid 34606875)
34. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102(39):13944-13949 (Pubitemid 41377683)
35. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99(24):15524-15529 (Pubitemid 35403967)
36. Akerman GS, Rosenzweig BA, Domon OE, Tsai CA, Bishop ME, McGarrity LJ, Macgregor JT, Sistare FD, Chen JJ, Morris SM (2005) Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ Mol Mutagen 45(2-3):188-205
37. Chung EY, Dews M, Cozma D, Yu D, Wentzel EA, Chang TC, Schelter JM, Cleary MA, Mendell JT, Thomas-Tikhonenko A (2008) c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster. Cancer Biol Ther 7(11): 1758-1764
38. Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 102(10): 3627-3632 (Pubitemid 40354662)
39. Shahi P, Loukianiouk S, Bohne-Lang A, Kenzelmann M, Kuffer S, Maertens S, Eils R, Grone HJ, Gretz N, Brors B (2006) Arg-onaute-a database for gene regulation by mammalian microR-NAs. Nucleic Acids Res 34(Database issue):D115-D118
40. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9(3):189-198 (Pubitemid 43357945)
41. Michael MZ, O'Connor SM, van Holst Pellekaan NG, Young GP, James RJ (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1(12):882-891 (Pubitemid 37288707)
42. Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65(14):6029-6033 (Pubitemid 40994386)
43. Cha HJ, Seong KM, Bae S, Jung JH, Kim CS, Yang KH, Jin YW, An S (2009) Identification of specific microRNAs responding to low and high dose gamma-irradiation in the human lymphoblast line IM9. Oncol Rep 22(4):863-868
44. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27(15):2128-2136 (Pubitemid 351485639)
45. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283(2):1026-1033
46. Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y (2008) MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27: 4373-4379 (Pubitemid 352010003)
47. Zhu S, Si ML, Wu H, Mo YY (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282(19):14328-14336 (Pubitemid 47100416)
48. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterol-ogy 133(2):647-658 (Pubitemid 47187346)
49. Sayed D, Rane S, Lypowy J, He M, Chen IY, Vashistha H, Yan L, Malhotra A, Vatner D, Abdellatif M (2008) MicroRNA-21 targets sprouty2 and promotes cellular outgrowths. Mol Biol Cell
50. Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ (2005) Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 164(1):17-26 (Pubitemid 40885226)
51. Long XH, Zhao ZQ, He XP, Wang HP, Xu QZ, An J, Bai B, Sui JL, Zhou PK (2007) Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells. Int J Mol Med 19(4):607-615
52. Fujimori A, Okayasu R, Ishihara H, Yoshida S, Eguchi-Kasai K, Nojima K, Ebisawa S, Takahashi S (2005) Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts. Cancer Res 65(22):10159-10163 (Pubitemid 41743703)
53. Fachin AL, Mello SS, Sandrin-Garcia P, Junta CM, Donadi EA, Passos GA, Sakamoto-Hojo ET (2007) Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. Radiat Res 168(6):650-665 (Pubitemid 351295101)
54. Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM, Fornace AJ Jr (2003) Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 1(6):445-452 (Pubitemid 36459255)
55. Sugihara T, Magae J, Wadhwa R, Kaul SC, Kawakami Y, Mat-sumoto T, Tanaka K (2004) Dose and dose-rate effects of low-dose ionizing radiation on activation of Trp53 in immortalized murine cells. Radiat Res 162(3):296-307 (Pubitemid 39295430)
56. Gridley DS, Pecaut MJ, Rizvi A, Coutrakon GB, Luo-Owen X, Makinde AY, Slater JM (2009) Low-dose, low-dose-rate proton radiation modulates CD4(?) T cell gene expression. Int J Radiat Biol 85(3):250-261