Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB

Metabolism: Clinical and Experimental

Volumn 61, Issue 8, 2012, Pages 1142-1151

  Lee, Min Suk ^a   Choi, Sung E ^a   Ha, Eun Suk ^a   An, So Yeon ^a   Kim, Tae Ho ^b   Han, Seung Jin ^a   Kim, Hae Jin ^a   Kim, Dae Jung ^a   Kang, Yup ^a   Lee, Kwan Woo ^a  

^a Ajou University School of Medicine   (South Korea)

^b Catholic Kwandong University   (South Korea)

Author keywords

2 N (7 nitrobenz 2 oxa 1,3 diazol 4 yl) amino 2 deoxyglucose; 2 NBDG; AMV; avian myeloblastosis virus; cDNA; complementary DNA; diet induced obese; DIO; FFA; FGF 21; fibroblast growth factor 21; free fatty acid; HSMMs; human skeletal muscle myotubes; NIDDM; non insulin dependent diabetes mellitus; PA; palmitate; PBS; phosphate buffered saline; siRNA; small interfering RNA

Indexed keywords

BETA KLOTHO PROTEIN; FIBROBLAST GROWTH FACTOR 21; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; PALMITIC ACID; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; MYOTUBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

4-CHLORO-7-NITROBENZOFURAZAN; BLOTTING, WESTERN; DEOXYGLUCOSE; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTORS; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 4; HUMANS; I-KAPPA B KINASE; INSULIN; INSULIN RESISTANCE; MAP KINASE KINASE 4; MUSCLE FIBERS, SKELETAL; NF-KAPPA B P50 SUBUNIT; PALMITIC ACID; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84864281810     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.01.012     Document Type: Article

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