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Volumn 29, Issue 7, 2012, Pages 822-834

Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswePS1dE9 transgenic model of Alzheimer disease: Effects of melatonin or ramelteon

Author keywords

Alzheimer disease; Body temperature rhythm; Circadian system; Hippocampus; Melatonin; Oxidative stress; Ramelteon; Spatial memory

Indexed keywords

AMYLOID PRECURSOR PROTEIN; INDENE DERIVATIVE; MELATONIN; MELATONIN RECEPTOR; MUTANT PROTEIN; PRESENILIN 1; RAMELTEON;

EID: 84864231259     PISSN: 07420528     EISSN: 15256073     Source Type: Journal    
DOI: 10.3109/07420528.2012.699119     Document Type: Article
Times cited : (48)

References (64)
  • 1
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE, Diamond DM. (2001). Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res. 891:42-53.
    • (2001) Brain Res. , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6    Diamond, D.M.7
  • 2
    • 0028124766 scopus 로고
    • What is sundowning?
    • Bliwise DL. (1994). What is sundowning? J. Am. Geriatr. Soc. 42:1009-1011.
    • (1994) J. Am. Geriatr. Soc. , vol.42 , pp. 1009-1011
    • Bliwise, D.L.1
  • 4
    • 31644432763 scopus 로고    scopus 로고
    • Beneficial effects of melatonin in experimental models of alzheimer disease
    • Cheng Y, Feng Z, Zhang QZ, Zhang JT. (2006). Beneficial effects of melatonin in experimental models of Alzheimer disease. Acta Pharmacol. Sin. 27:129-139.
    • (2006) Acta Pharmacol. Sin. , vol.27 , pp. 129-139
    • Cheng, Y.1    Feng, Z.2    Zhang, Q.Z.3    Zhang, J.T.4
  • 5
    • 0028865501 scopus 로고
    • The neuropsychological differentiation of patients with very mild alzheimer's disease and/or major depression
    • desRosiers G, Hodges JR, Berrios G. (1995). The neuropsychological differentiation of patients with very mild Alzheimer's disease and/or major depression. Am. Geriatr. Soc. 43:1256-1263.
    • (1995) Am. Geriatr. Soc. , vol.43 , pp. 1256-1263
    • Desrosiers, G.1    Hodges, J.R.2    Berrios, G.3
  • 7
    • 36949016215 scopus 로고    scopus 로고
    • Alzheimer disease models and human neuropathology: Similarities and differences
    • Duyckaerts C, Potier MC, Delatour B. (2008). Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 115:5-38.
    • (2008) Acta Neuropathol. , vol.115 , pp. 5-38
    • Duyckaerts, C.1    Potier, M.C.2    Delatour, B.3
  • 8
    • 67349143998 scopus 로고    scopus 로고
    • Classification and basic pathology of alzheimer disease
    • Duyckaerts C, Delatour B, Potier MC. (2009). Classification and basic pathology of Alzheimer disease. Acta Neuropathol. 118:5-36.
    • (2009) Acta Neuropathol. , vol.118 , pp. 5-36
    • Duyckaerts, C.1    Delatour, B.2    Potier, M.C.3
  • 9
    • 16244386842 scopus 로고    scopus 로고
    • Detailed analysis of the behavior of lister and wistar rats in anxiety, object recognition and object location tasks
    • Ennaceur A, Michalikova S, Bradford A, Ahmed S. (2005). Detailed analysis of the behavior of Lister and Wistar rats in anxiety, object recognition and object location tasks. Behau. Brain Res. 159:247-266.
    • (2005) Behau. Brain Res. , vol.159 , pp. 247-266
    • Ennaceur, A.1    Michalikova, S.2    Bradford, A.3    Ahmed, S.4
  • 10
    • 28744450569 scopus 로고    scopus 로고
    • Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of alzheimer's disease
    • Feng Z, Qin C, Chang Y, Zhang JT. (2006). Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radie. Biol. Med. 40:101-109.
    • (2006) Free Radie. Biol. Med. , vol.40 , pp. 101-109
    • Feng, Z.1    Qin, C.2    Chang, Y.3    Zhang, J.T.4
  • 11
    • 49549113573 scopus 로고    scopus 로고
    • Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat
    • Fisher SP, Davidson K, Kulla A, Sugden D. (2008). Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. J. Pineal Res. 45:125-132.
    • (2008) J. Pineal Res. , vol.45 , pp. 125-132
    • Fisher, S.P.1    Davidson, K.2    Kulla, A.3    Sugden, D.4
  • 13
    • 44649201121 scopus 로고    scopus 로고
    • Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks
    • Frye CA, Waif AA. (2008). Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks. Neurobiol. Learn. Mem. 90:171-177.
    • (2008) Neurobiol. Learn. Mem. , vol.90 , pp. 171-177
    • Frye, C.A.1    Waif, A.A.2
  • 15
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A, Tan DX, Reiter RJ. (2011). Melatonin as a natural ally against oxidative stress: a physicochemical examination. J. Pineal Res. 51:1-16.
    • (2011) J. Pineal Res. , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 16
    • 70349876561 scopus 로고    scopus 로고
    • Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of alzheimer's disease
    • Garcia T, Ribes D, Colomina MT, Cabré M, Domingo JL, Gómez M. (2009). Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease. Toxicology 265:49-55.
    • (2009) Toxicology , vol.265 , pp. 49-55
    • Garcia, T.1    Ribes, D.2    Colomina, M.T.3    Cabré, M.4    Domingo, J.L.5    Gómez, M.6
  • 18
    • 77955006508 scopus 로고    scopus 로고
    • Lifespan daily locomotor activity rhythms in a mouse model of amyloid-induced neuropathology
    • Gorman MR, Yellon S. (2010). Lifespan daily locomotor activity rhythms in a mouse model of amyloid-induced neuropathology. Chronobiol. Int. 27:1159-1177.
    • (2010) Chronobiol. Int. , vol.27 , pp. 1159-1177
    • Gorman, M.R.1    Yellon, S.2
  • 19
    • 43649097836 scopus 로고    scopus 로고
    • Aged wild-type and APP, ps1, and app+ps1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load
    • Gruart A, López-Ramos JC, Munoz MD, Delgado-Garcfa JM. (2008). Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load. Neurobiol. Dis. 30:439-450.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 439-450
    • Gruart, A.1    López-Ramos, J.C.2    Munoz, M.D.3    Delgado-Garcfa, J.M.4
  • 20
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and alzheimer's disease
    • Hardy J. (1997). Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20:154-159.
    • (1997) Trends Neurosci. , vol.20 , pp. 154-159
    • Hardy, J.1
  • 21
    • 12244286055 scopus 로고    scopus 로고
    • Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats
    • Hirai K, Kita M, Ohta H, Nishikawa H, Fujiwara Y, Ohkawa S, Miyamoto M. (2005). Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J. Biol. Rhythms 20:27-37.
    • (2005) J. Biol. Rhythms , vol.20 , pp. 27-37
    • Hirai, K.1    Kita, M.2    Ohta, H.3    Nishikawa, H.4    Fujiwara, Y.5    Ohkawa, S.6    Miyamoto, M.7
  • 22
    • 3142668938 scopus 로고    scopus 로고
    • Cognitive correlates of aß deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
    • Howlett DR, Richardson JC, Austin A, Parsons AA, Bate ST, Davies DC, Gonzalez MI. (2004). Cognitive correlates of Aß deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. Brain Res. 1017:130-136.
    • (2004) Brain Res , vol.1017 , pp. 130-136
    • Howlett, D.R.1    Richardson, J.C.2    Austin, A.3    Parsons, A.A.4    Bate, S.T.5    Davies, D.C.6    Gonzalez, M.I.7
  • 25
    • 79951595560 scopus 로고    scopus 로고
    • Circadian dysfunction in P23H rhodopsin transgenic rats: Effects of exogenous melatonin
    • Lax P, Otalora BB, Esquiva G, Roi M de L, Madrid JA, Cuenca N. (2011). Circadian dysfunction in P23H rhodopsin transgenic rats: effects of exogenous melatonin. J. Pineal Res. 50:183-191.
    • (2011) J. Pineal Res. , vol.50 , pp. 183-191
    • Lax, P.1    Otalora, B.B.2    Esquiva, G.3    De Roi, M.L.4    Madrid, J.A.5    Cuenca, N.6
  • 28
    • 3242740203 scopus 로고    scopus 로고
    • Melatonin treatment of day-night rhythm disturbances and sundowning in alzheimer disease: An open-label pilot study using actigraphy
    • Mahlberg R, Kunz D, Sutej I, Kühl KP, Hellweg R. (2004). Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J. Clin. Psychopharmacol. 24:456-459.
    • (2004) J. Clin. Psychopharmacol. , vol.24 , pp. 456-459
    • Mahlberg, R.1    Kunz, D.2    Sutej, I.3    Kühl, K.P.4    Hellweg, R.5
  • 30
    • 54549122746 scopus 로고    scopus 로고
    • Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat
    • Mathes AM, Kubulus D, Waibel L, Weiler J, Heymann P, Wolf B, Rensing H. (2008). Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat. Crit. Care Med. 36:2863-2870.
    • (2008) Crit. Care Med. , vol.36 , pp. 2863-2870
    • Mathes, A.M.1    Kubulus, D.2    Waibel, L.3    Weiler, J.4    Heymann, P.5    Wolf, B.6    Rensing, H.7
  • 32
    • 6344247564 scopus 로고    scopus 로고
    • Memantine improves spatial learning in a transgenic mouse model of alzheimer's disease
    • Minkeviciene R, Banerjee P, Tanila H. (2004). Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease. Pharmacol. Exp. Ther. 311:677-682.
    • (2004) Pharmacol. Exp. Ther. , vol.311 , pp. 677-682
    • Minkeviciene, R.1    Banerjee, P.2    Tanila, H.3
  • 33
    • 33744923689 scopus 로고    scopus 로고
    • Effect of ramelteon (TAK-375), a selective mt1/mt2 receptor agonist, on motor performance in mice
    • Miyamoto M. (2006). Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice. Neurosci. Lett. 402:201-204.
    • (2006) Neurosci. Lett. , vol.402 , pp. 201-204
    • Miyamoto, M.1
  • 34
    • 67649905028 scopus 로고    scopus 로고
    • Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of alzheimer disease./
    • Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW. (2009). Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease./Pineal Res. 47:82-96.
    • (2009) Pineal Res , vol.47 , pp. 82-96
    • Olcese, J.M.1    Cao, C.2    Mori, T.3    Mamcarz, M.B.4    Maxwell, A.5    Runfeldt, M.J.6    Wang, L.7    Zhang, C.8    Lin, X.9    Zhang, G.10    Arendash, G.W.11
  • 35
    • 78649647292 scopus 로고    scopus 로고
    • A new integrated variable based on thermometry, actimetry and body position (TAP) to evaluate circadian system status in humans
    • Ortiz-Tudela E, Martinez-Nicolas A, Campos M, Roi MÂ, Madrid JA. (2010). A new integrated variable based on thermometry, actimetry and body position (TAP) to evaluate circadian system status in humans. PLoS Comput. Biol. 6:el000996.
    • (2010) PLoS Comput. Biol. , vol.6
    • Ortiz-Tudela, E.1    Martinez-Nicolas, A.2    Campos, M.3    Roi, M.Â.4    Madrid, J.A.5
  • 36
    • 40849126868 scopus 로고    scopus 로고
    • Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing c57bl6 mice
    • Otâlora BB, Madrid JA, Alvarez N, Vicente V, Rol MA. (2008). Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing C57BL6 mice. J. Pineal Res. 44:307-315.
    • (2008) J. Pineal Res. , vol.44 , pp. 307-315
    • Otâlora, B.B.1    Madrid, J.A.2    Alvarez, N.3    Vicente, V.4    Rol, M.A.5
  • 37
    • 0033968704 scopus 로고    scopus 로고
    • An assessment of the antioxidant and the antia-myloidogenic properties of melatonin: Implications for alzheimer's disease./
    • Pappolla MA, Chyan YJ, Poeggeler B, Frangione B, Wilson G, Ghiso J, Reiter RJ. (2000). An assessment of the antioxidant and the antia-myloidogenic properties of melatonin: implications for Alzheimer's disease./Neural Transm. 107:203-231.
    • (2000) Neural Transm , vol.107 , pp. 203-231
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3    Frangione, B.4    Wilson, G.5    Ghiso, J.6    Reiter, R.J.7
  • 38
    • 0035992622 scopus 로고    scopus 로고
    • Melatonin's unique radical scavenging properties-roles of its functional substituents as revealed by a comparison with its structural analogs
    • Poeggeler B, Thuermann S, Dose A, Schoenke M, Burkhardt S, Harde-land R. (2002). Melatonin's unique radical scavenging properties-roles of its functional substituents as revealed by a comparison with its structural analogs. J. Pineal Res. 33:20-30.
    • (2002) J. Pineal Res. , vol.33 , pp. 20-30
    • Poeggeler, B.1    Thuermann, S.2    Dose, A.3    Schoenke, M.4    Burkhardt, S.5    Harde-Land, R.6
  • 39
    • 78049250447 scopus 로고    scopus 로고
    • Ethics and methods for biological rhythm research on animals and human beings
    • Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911-1929.
    • (2010) Chronobiol. Int. , vol.27 , pp. 1911-1929
    • Portaluppi, F.1    Smolensky, M.H.2    Touitou, Y.3
  • 40
    • 14944341045 scopus 로고    scopus 로고
    • Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old tg2576 mice: Implications for clinical trials
    • Quinn J, Kulhanek D, Nowlin J, Jones R, Praticö D, Rokach J, Stackman R. (2005). Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials. Brain Res. 1037:209-213.
    • (2005) Brain Res , vol.1037 , pp. 209-213
    • Quinn, J.1    Kulhanek, D.2    Nowlin, J.3    Jones, R.4    Praticö, D.5    Rokach, J.6    Stackman, R.7
  • 41
    • 0023834995 scopus 로고
    • Reentrainment of rat circadian activity rhythms: Effects of melatonin
    • Redman JR, Armstrong SM. (1988). Reentrainment of rat circadian activity rhythms: effects of melatonin. J. Pineal Res. 5:203-215.
    • (1988) J. Pineal Res. , vol.5 , pp. 203-215
    • Redman, J.R.1    Armstrong, S.M.2
  • 42
    • 33846153236 scopus 로고    scopus 로고
    • Impaired spatial learning in the appswe+psenldeltae9 bigenic mouse model of alzheimer's disease
    • Reiserer RS, Harrison FE, Syverud DC, McDonald MP. (2007). Impaired spatial learning in the APPSwe+PSENlDeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behau. 6:54-65.
    • (2007) Genes Brain Behau , vol.6 , pp. 54-65
    • Reiserer, R.S.1    Harrison, F.E.2    Syverud, D.C.3    McDonald, M.P.4
  • 45
    • 0028882055 scopus 로고
    • Circadian locomotor activity and core-body temperature rhythms in alzheimer's disease
    • Satlin A, Volicer L, Stopa EG, Harper D. (1995). Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease. Neurobiol. Aging 16:765-771.
    • (1995) Neurobiol. Aging , vol.16 , pp. 765-771
    • Satlin, A.1    Volicer, L.2    Stopa, E.G.3    Harper, D.4
  • 48
  • 49
    • 78650810278 scopus 로고    scopus 로고
    • Chronic treatment with the a(2)-adrenoceptor antagonist fluparox-an prevents age-related deficits in spatial working memory in appxpsl transgenic mice without altering ß-amyloid plaque load or astrocytosis
    • Scullion GA, Kendall DA, Marsden CA, Sunter D, Pardon MC. (2011). Chronic treatment with the a(2)-adrenoceptor antagonist fluparox-an prevents age-related deficits in spatial working memory in APPxPSl transgenic mice without altering ß-amyloid plaque load or astrocytosis. Neuropharmacology 60:223-234.
    • (2011) Neuropharmacology , vol.60 , pp. 223-234
    • Scullion, G.A.1    Kendall, D.A.2    Marsden, C.A.3    Sunter, D.4    Pardon, M.C.5
  • 50
    • 77955714612 scopus 로고    scopus 로고
    • Characterization of the 3XTg-ad mouse model of alzheimer's disease: Part 1. Circadian changes
    • SterniczukR, DyckRH, Laferla FM, Antle MC. (2010). Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes. Brain Res. 1348:139-148.
    • (2010) Brain Res , vol.1348 , pp. 139-148
    • Sterniczuk, R.1    Dyck, R.H.2    Laferla, F.M.3    Antle, M.C.4
  • 52
    • 23744513206 scopus 로고    scopus 로고
    • A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
    • Tomâs-Zapico C, Coto-Montes A. (2005). A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J. Pineal Res. 39:99-104.
    • (2005) J. Pineal Res. , vol.39 , pp. 99-104
    • Tomâs-Zapico, C.1    Coto-Montes, A.2
  • 53
  • 55
    • 84937366896 scopus 로고
    • Sleep in alzheimer's disease and the sundown syndrome
    • Vitiello MV, Bliwise DL, Prinz PN. (1992). Sleep in Alzheimer's disease and the sundown syndrome. Neurology 42:83-93.
    • (1992) Neurology , vol.42 , pp. 83-93
    • Vitiello, M.V.1    Bliwise, D.L.2    Prinz, P.N.3
  • 56
    • 33847679964 scopus 로고    scopus 로고
    • Looking for the keys to diurnality downstream from the circadian clock: Role of melatonin in a dual-phasing rodent, octadon degus
    • Vivanco P, Ortiz V, Rol MA, Madrid JA. (2007). Looking for the keys to diurnality downstream from the circadian clock: role of melatonin in a dual-phasing rodent, Octadon degus. J. Pineal Res. 42:280-290.
    • (2007) J. Pineal Res. , vol.42 , pp. 280-290
    • Vivanco, P.1    Ortiz, V.2    Rol, M.A.3    Madrid, J.A.4
  • 59
    • 13544275103 scopus 로고    scopus 로고
    • Sleep and circadian abnormalities in a transgenic mouse model of alzheimer's disease: A role for cholinergic transmission
    • Wisor JP, Edgar DM, Yesavage J, Ryan HS, McCormick CM, Lapustea N, Murphy GM (2005). Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission. Neuroscience 131:375-385.
    • (2005) Neuroscience , vol.131 , pp. 375-385
    • Wisor, J.P.1    Edgar, D.M.2    Yesavage, J.3    Ryan, H.S.4    McCormick, C.M.5    Lapustea, N.6    Murphy, G.M.7
  • 60
    • 0023201142 scopus 로고
    • Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct
    • Wong SH, Knight JA, Hopfer SM, Zaharia O, Leach CN, Sunderman FW Jr. (1987). Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin. Chem. 33:214-220.
    • (1987) Clin. Chem. , vol.33 , pp. 214-220
    • Wong, S.H.1    Knight, J.A.2    Hopfer, S.M.3    Zaharia, O.4    Leach, C.N.5    Sunderman, Jr.F.W.6
  • 61
    • 15444363809 scopus 로고    scopus 로고
    • The human pineal gland and melatonin in aging and alzheimer's disease
    • Wu YH, Swaab DF. (2005). The human pineal gland and melatonin in aging and Alzheimer's disease. J. Pineal Res. 38:145-152.
    • (2005) J. Pineal Res. , vol.38 , pp. 145-152
    • Wu, Y.H.1    Swaab, D.F.2
  • 62
    • 34547547735 scopus 로고    scopus 로고
    • Disturbance and strategies for reactivation of the circadian rhythm system in aging and alzheimer's disease
    • Wu YH, Swaab DF. (2007). Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med. 8:623-636.
    • (2007) Sleep Med. , vol.8 , pp. 623-636
    • Wu, Y.H.1    Swaab, D.F.2
  • 63
    • 34249291586 scopus 로고    scopus 로고
    • Decreased mt1 melatonin receptor expression in the suprachias-matic nucleus in aging and alzheimer's disease
    • Wu YH, Zhou JN, Van Heerikhuize J, Jockers R, Swaab DF. (2007). Decreased MT1 melatonin receptor expression in the suprachias-matic nucleus in aging and Alzheimer's disease. Neurobiol. Aging 28:1239-1247.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1239-1247
    • Wu, Y.H.1    Zhou, J.N.2    Van Heerikhuize, J.3    Jockers, R.4    Swaab, D.F.5


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