Structure-based design and screen of novel inhibitors for class II 3-hydroxy-3-methylglutaryl coenzyme a reductase from Streptococcus pneumoniae

Journal of Chemical Information and Modeling

Volumn 52, Issue 7, 2012, Pages 1833-1841

  Li, Ding ^a   Gui, Jie ^a   Li, Yongjian ^a   Feng, Lingling ^a   Han, Xinya ^a   Sun, Yao ^a   Sun, Tinglin ^a   Chen, Zhigang ^a   Cao, Yi ^a   Zhang, Yang ^a   Zhou, Li ^a   Hu, Xiaopeng ^b   Ren, Yanliang ^a   Wan, Jian ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYMES; DIAGNOSIS; LEAD COMPOUNDS;

3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; FLUORESCENCE SPECTRA; HYPERCHOLESTEROLEMIA; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL DIVERSITY; STRUCTURE-BASED DESIGNS; THREE DIMENSIONAL (3D) STRUCTURES;

3D MODELING;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVE SITE; IC 50; MOLECULAR DYNAMICS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; DRUG EFFECTS; IC50;

CATALYTIC DOMAIN; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864203547     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci300163v     Document Type: Review

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