Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3512-3519

  Feng, Lingling ^a,b   Zhou, Li ^a   Sun, Yao ^a   Gui, Jie ^a   Wang, Xiaofeng ^a   Wu, Ping ^b   Wan, Jian ^a   Ren, Yanliang ^a   Qiu, Shengxiang ^b   Wei, Xiaoyi ^b   Li, Jun ^c  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b SOUTH CHINA INSTITUTE OF BOTANY   (China)

^c INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

3 Hydroxy 3 methylglutaryl coenzyme A reductase (class II HMGR); Annonaceous acetogenin; Computer modeling and docking simulation; Inhibition; Streptococcus pneumoniae

Indexed keywords

ACETOGENIN; ASIMICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; SQUAMOCIN; SQUAMOCIN C; SQUAMOSTATIN A; SQUAMOSTATIN B; UNCLASSIFIED DRUG;

ANNONA SQUAMOSA; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; MEDICINAL PLANT; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STREPTOCOCCUS PNEUMONIAE;

ACETOGENINS; AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 79957440771     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.019     Document Type: Article

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