Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating α-asarone-based HMG-CoA reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4238-4248

  Argüelles, Nancy ^a   Sánchez Sandoval, Eugenia ^a   Mendieta, Aarón ^a   Villa Tanaca, Lourdes ^a   Garduño Siciliano, Leticia ^a   Jiménez, Fabiola ^a   Cruz, María del Carmen ^a   Medina Franco, José L ^b   Chamorro Cevallos, Germán ^a   Tamariz, Joaquín ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Alpha asarone; Docking; HMG CoA reductase; Hypocholesterolemic activity; Schizosaccharomyces pombe

Indexed keywords

2 (2 METHOXY 4 PROPYLPHENOXY)ACETIC ACID; 2 (2 METHOXY 5 NITRO 4 PROPYLPHENOXY)ACETIC ACID; 2 [4,5 DIMETHOXYPHENOL]; 4,5 DIMETHOXY 2 PROPYLPHENOL; ALPHA ASARONE; ANTILIPEMIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYL 2 (2 METHOXY 5 NITRO 4 PROPYLPHENOXY)ACETATE; METHYL 2 (4 5 HYDROXY 2 METHOXYPHENOXY)ACETATE; METHYL 2 (5 AMINO 2 METHOXY 4 PROPYLPHENOXY)ACETATE; METHYL 2 (5 HYDROXY 2 METHOXY 4 PROPYLPHENOXY)ACETATE; SIMVASTATIN; TYLOXAPOL; UNCLASSIFIED DRUG; ANISOLE DERIVATIVE; ASARONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; DRUG RESEARCH; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PURIFICATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; SCHIZOSACCHAROMYCES POMBE; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODEL; DRUG EFFECTS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; SCHIZOSACCHAROMYCES; SYNTHESIS;

ANIMALS; ANISOLES; BINDING SITES; COMPUTER SIMULATION; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MICE; MICE, INBRED ICR; SCHIZOSACCHAROMYCES;

MURINAE; SCHIZOSACCHAROMYCES POMBE;

EID: 77953126688     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.096     Document Type: Article

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