Structure-based rational quest for potential novel inhibitors of human HMG-CoA reductase by combining CoMFA 3D QSAR modeling and virtual screening

Journal of Combinatorial Chemistry

Volumn 9, Issue 1, 2007, Pages 131-138

  Zhang, Qing Y ^a   Wan, Jian ^a   Xu, Xin ^b   Yang, Guang F ^a   Ren, Yan L ^a   Liu, Jun J ^a   Wang, Hui ^c   Guo, Yu ^c  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b XIAMEN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ELECTRICITY; HUMAN; METABOLISM; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DESIGN; ELECTROSTATICS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846601387     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc060101e     Document Type: Article

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