-
1
-
-
70349442548
-
The first 30 years of p53: Growing ever more complex
-
Levine AJ, Oren M (2009) The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9(10):749-758
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.10
, pp. 749-758
-
-
Levine, A.J.1
Oren, M.2
-
2
-
-
65349103899
-
Blinded by the light: The growing complexity of p53
-
Vousden KH, Prives C (2009) Blinded by the light: the growing complexity of p53. Cell 137(3):413-431
-
(2009)
Cell
, vol.137
, Issue.3
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
3
-
-
0032161624
-
P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
-
Yang A et al (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2(3):305-316
-
(1998)
Mol Cell
, vol.2
, Issue.3
, pp. 305-316
-
-
Yang, A.1
-
4
-
-
0030812331
-
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
-
Kaghad M et al (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90(4):809-819
-
(1997)
Cell
, vol.90
, Issue.4
, pp. 809-819
-
-
Kaghad, M.1
-
5
-
-
80051789515
-
P63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
-
Melino G (2011) p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ
-
(2011)
Cell Death Differ
-
-
Melino, G.1
-
7
-
-
0033594485
-
P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
-
Yang A et al (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398 (6729):714-718
-
(1999)
Nature
, vol.398
, Issue.6729
, pp. 714-718
-
-
Yang, A.1
-
8
-
-
0033552638
-
Twenty years of p53 research: Structural and functional aspects of the p53 protein
-
May P, May E (1999) Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 18 (53):7621-7636
-
(1999)
Oncogene
, vol.18
, Issue.53
, pp. 7621-7636
-
-
May, P.1
May, E.2
-
9
-
-
80053015725
-
P53 isoforms: An intracellular microprocessor?
-
Khoury MP, Bourdon J-C (2011) P53 isoforms: an intracellular microprocessor? Genes Cancer 2(4):453-465
-
(2011)
Genes Cancer
, vol.2
, Issue.4
, pp. 453-465
-
-
Khoury, M.P.1
Bourdon, J.-C.2
-
10
-
-
59349099726
-
P53 isoforms - A conspiracy to kidnap p53 tumor suppressor activity?
-
Marcel V, Hainaut P (2009) P53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity? Cell Mol Life Sci 66(3):391-406
-
(2009)
Cell Mol Life Sci
, vol.66
, Issue.3
, pp. 391-406
-
-
Marcel, V.1
Hainaut, P.2
-
11
-
-
17544363909
-
P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
-
Yang A et al (2000) P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404(6773):99-103
-
(2000)
Nature
, vol.404
, Issue.6773
, pp. 99-103
-
-
Yang, A.1
-
12
-
-
0036568390
-
Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck
-
Weber A et al (2002) Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck. Int J Cancer 99(1):22-28
-
(2002)
Int J Cancer
, vol.99
, Issue.1
, pp. 22-28
-
-
Weber, A.1
-
13
-
-
77953170345
-
P73 tumor suppressor protein: A close relative of p53 not only in structure but also in anti-cancer approach?
-
Zawacka-Pankau J et al (2010) P73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach? Cell Cycle 9(4) 1
-
(2010)
Cell Cycle
, vol.9
, Issue.4
, pp. 1
-
-
Zawacka-Pankau, J.1
-
14
-
-
53549134949
-
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
-
Tomasini R et al (2008) TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22(19):2677-2691
-
(2008)
Genes Dev
, vol.22
, Issue.19
, pp. 2677-2691
-
-
Tomasini, R.1
-
15
-
-
34547753615
-
P63 and p73 in human cancer: Defining the network
-
Deyoung MP, Ellisen LW (2007) P63 and p73 in human cancer: defining the network. Oncogene 26(36):5169-5183
-
(2007)
Oncogene
, vol.26
, Issue.36
, pp. 5169-5183
-
-
Deyoung, M.P.1
Ellisen, L.W.2
-
16
-
-
0033594491
-
P63 is a p53 homologue required for limb and epidermal morphogenesis
-
Mills AA et al (1999) P63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398(6729):708-713
-
(1999)
Nature
, vol.398
, Issue.6729
, pp. 708-713
-
-
Mills, A.A.1
-
17
-
-
0037377761
-
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
-
Westfall MD et al (2003) The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 23(7):2264-2276
-
(2003)
Mol Cell Biol
, vol.23
, Issue.7
, pp. 2264-2276
-
-
Westfall, M.D.1
-
18
-
-
0034743628
-
P63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
-
Dohn M, Zhang S, Chen X (2001) P63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 20(25):3193-3205
-
(2001)
Oncogene
, vol.20
, Issue.25
, pp. 3193-3205
-
-
Dohn, M.1
Zhang, S.2
Chen, X.3
-
19
-
-
0036892018
-
Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains
-
Ghioni P et al (2002) Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol Cell Biol 22(24):8659-8668
-
(2002)
Mol Cell Biol
, vol.22
, Issue.24
, pp. 8659-8668
-
-
Ghioni, P.1
-
20
-
-
33646365381
-
The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63
-
Helton ES, Zhu J, Chen X (2006) The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J Biol Chem 281(5):2533-2542
-
(2006)
J Biol Chem
, vol.281
, Issue.5
, pp. 2533-2542
-
-
Helton, E.S.1
Zhu, J.2
Chen, X.3
-
21
-
-
70350674206
-
Identification and functional characterization of two new transcriptional variants of the human p63 gene
-
Mangiulli M et al (2009) Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res 37(18):6092-6104
-
(2009)
Nucleic Acids Res
, vol.37
, Issue.18
, pp. 6092-6104
-
-
Mangiulli, M.1
-
22
-
-
0032771021
-
P53 Family members p63 and p73 are SAM domain-containing proteins
-
Thanos CD, Bowie JU (1999) P53 Family members p63 and p73 are SAM domain-containing proteins. Protein Sci 8(8):1708-1710
-
(1999)
Protein Sci
, vol.8
, Issue.8
, pp. 1708-1710
-
-
Thanos, C.D.1
Bowie, J.U.2
-
23
-
-
18744406283
-
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism
-
Serber Z et al (2002) A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol 22 (24):8601-8611
-
(2002)
Mol Cell Biol
, vol.22
, Issue.24
, pp. 8601-8611
-
-
Serber, Z.1
-
24
-
-
70449713323
-
Conformational stability and activity of p73 require a second helix in the tetramerization domain
-
Coutandin D et al (2009) Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Differ 16(12):1582-1589
-
(2009)
Cell Death Differ
, vol.16
, Issue.12
, pp. 1582-1589
-
-
Coutandin, D.1
-
25
-
-
70449588702
-
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
-
Joerger A et al (2009) Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci USA
-
(2009)
Proc Natl Acad Sci USA
-
-
Joerger, A.1
-
26
-
-
0035131701
-
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
-
Gaiddon C et al (2001) A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 21(5):1874-1887
-
(2001)
Mol Cell Biol
, vol.21
, Issue.5
, pp. 1874-1887
-
-
Gaiddon, C.1
-
27
-
-
30344450404
-
P63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
-
Rocco JW et al (2006) P63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell 9(1):45-56
-
(2006)
Cancer Cell
, vol.9
, Issue.1
, pp. 45-56
-
-
Rocco, J.W.1
-
28
-
-
0033603494
-
P73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
-
Davison TS et al (1999) P73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J Biol Chem 274(26):18709-18714
-
(1999)
J Biol Chem
, vol.274
, Issue.26
, pp. 18709-18714
-
-
Davison, T.S.1
-
29
-
-
21744440252
-
DNA-binding and transactivation activities are essential for TAp63 protein degradation
-
Ying H et al (2005) DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol 25 (14):6154-6164
-
(2005)
Mol Cell Biol
, vol.25
, Issue.14
, pp. 6154-6164
-
-
Ying, H.1
-
30
-
-
0034938829
-
P63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast
-
Barbareschi M et al (2001) P63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol 25(8):1054-1060
-
(2001)
Am J Surg Pathol
, vol.25
, Issue.8
, pp. 1054-1060
-
-
Barbareschi, M.1
-
31
-
-
0033637118
-
P63 is a prostate basal cell marker and is required for prostate development
-
Signoretti S et al (2000) P63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 157 (6):1769-1775
-
(2000)
Am J Pathol
, vol.157
, Issue.6
, pp. 1769-1775
-
-
Signoretti, S.1
-
32
-
-
34547513872
-
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2
-
Candi E et al (2007) DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci USA 104(29):11999-12004
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.29
, pp. 11999-12004
-
-
Candi, E.1
-
33
-
-
33646711244
-
P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
-
Laurikkala J et al (2006) P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development 133(8):1553-1563
-
(2006)
Development
, vol.133
, Issue.8
, pp. 1553-1563
-
-
Laurikkala, J.1
-
34
-
-
70350506325
-
Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death
-
Gonfloni S et al (2009) Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med 15(10):1179-1185
-
(2009)
Nat Med
, vol.15
, Issue.10
, pp. 1179-1185
-
-
Gonfloni, S.1
-
35
-
-
33845244180
-
P63 protects the female germ line during meiotic arrest
-
Suh E-K et al (2006) P63 protects the female germ line during meiotic arrest. Nature 444(7119):624-628
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 624-628
-
-
Suh, E.-K.1
-
36
-
-
33747872417
-
Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis
-
Barbieri CE et al (2006) Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res 66(15):7589-7597
-
(2006)
Cancer Res
, vol.66
, Issue.15
, pp. 7589-7597
-
-
Barbieri, C.E.1
-
37
-
-
33744796255
-
P63 regulates an adhesion programme and cell survival in epithelial cells
-
Carroll DK et al (2006) p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol 8(6):551-561
-
(2006)
Nat Cell Biol
, vol.8
, Issue.6
, pp. 551-561
-
-
Carroll, D.K.1
-
38
-
-
66049096917
-
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate
-
Romano R-A et al (2009) An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One 4(5):e5623
-
(2009)
Plos One
, vol.4
, Issue.5
, pp. 5623
-
-
Romano, R.-A.1
-
39
-
-
80054744189
-
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis
-
Ferretti E et al (2011) A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell 21(4):627-641
-
(2011)
Dev Cell
, vol.21
, Issue.4
, pp. 627-641
-
-
Ferretti, E.1
-
40
-
-
33847022319
-
Key role of p63 in BMP-4-induced epidermal commitment of embryonic stem cells
-
Aberdam D et al (2007) Key role of p63 in BMP-4-induced epidermal commitment of embryonic stem cells. Cell Cycle 6 (3):291-294
-
(2007)
Cell Cycle
, vol.6
, Issue.3
, pp. 291-294
-
-
Aberdam, D.1
-
41
-
-
33847055513
-
P63 in skin appendage development
-
Mikkola ML (2007) p63 in skin appendage development. Cell Cycle 6(3):285-290
-
(2007)
Cell Cycle
, vol.6
, Issue.3
, pp. 285-290
-
-
Mikkola, M.L.1
-
42
-
-
77950571925
-
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma
-
Herfs M et al (2010) Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma. Am J Pathol
-
(2010)
Am J Pathol
-
-
Herfs, M.1
-
43
-
-
35148852661
-
Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma
-
Higashikawa K et al (2007) Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma. Cancer Res 67(19):9207-9213
-
(2007)
Cancer Res
, vol.67
, Issue.19
, pp. 9207-9213
-
-
Higashikawa, K.1
-
44
-
-
13244283006
-
The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells
-
Petitjean A et al (2005) The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells. Oncogene 24 (3):512-519
-
(2005)
Oncogene
, vol.24
, Issue.3
, pp. 512-519
-
-
Petitjean, A.1
-
45
-
-
77957745623
-
Transcriptional activity of TAp63 promoter is regulated by c-jun
-
Yao J-Y, Pao C-C, Chen J-K (2010) Transcriptional activity of TAp63 promoter is regulated by c-jun. J Cell Physiol 225 (3):898-904
-
(2010)
J Cell Physiol
, vol.225
, Issue.3
, pp. 898-904
-
-
Yao, J.-Y.1
Pao, C.-C.2
Chen, J.-K.3
-
46
-
-
77749311480
-
TAp63 is a transcriptional target of NF-kappaB
-
Wu J et al (2010) TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem 109(4):702-710
-
(2010)
J Cell Biochem
, vol.109
, Issue.4
, pp. 702-710
-
-
Wu, J.1
-
47
-
-
45449097073
-
MiR-203 represses ‘stemness’ by repressing DeltaNp63
-
Lena A. et al (2008) miR-203 represses ‘stemness’ by repressing DeltaNp63. Cell Death Differ
-
(2008)
Cell Death Differ
-
-
Lena, A.1
-
48
-
-
40749111551
-
A skin microRNA promotes differentiation by repressing ‘stemness’
-
Yi R et al (2008) A skin microRNA promotes differentiation by repressing ‘stemness’. Nature 452(7184):225-229
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 225-229
-
-
Yi, R.1
-
49
-
-
70350560746
-
The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms
-
Manni I et al (2009) The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms. FASEB J
-
(2009)
FASEB J
-
-
Manni, I.1
-
50
-
-
54249136806
-
MicroRNA- 21 targets a network of key tumor-suppressive pathways in glioblastoma cells
-
Papagiannakopoulos T, Shapiro A, Kosik KS (2008) MicroRNA- 21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 68(19):8164-8172
-
(2008)
Cancer Res
, vol.68
, Issue.19
, pp. 8164-8172
-
-
Papagiannakopoulos, T.1
Shapiro, A.2
Kosik, K.S.3
-
51
-
-
0033881433
-
Down-regulation of p63 is required for epidermal UV-B-induced apoptosis
-
Liefer KM et al (2000) Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res 60 (15):4016-4020
-
(2000)
Cancer Res
, vol.60
, Issue.15
, pp. 4016-4020
-
-
Liefer, K.M.1
-
52
-
-
25144495237
-
Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha
-
Westfall MD et al (2005) Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha. Cell Cycle 4(5):710-716
-
(2005)
Cell Cycle
, vol.4
, Issue.5
, pp. 710-716
-
-
Westfall, M.D.1
-
53
-
-
27144448738
-
A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UVinduced apoptosis of keratinocytes
-
Papoutsaki M et al (2005) A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UVinduced apoptosis of keratinocytes. Oncogene 24(46):6970-6975
-
(2005)
Oncogene
, vol.24
, Issue.46
, pp. 6970-6975
-
-
Papoutsaki, M.1
-
54
-
-
76749100683
-
Regulation of p53 Family Member Isoform Delta}Np63{alpha by the Nuclear Factor-{kappa}B Targeting Kinase I{kappa}B Kinase {beta}
-
Chatterjee A et al (2010) Regulation of p53 Family Member Isoform Delta}Np63{alpha by the Nuclear Factor-{kappa}B Targeting Kinase I{kappa}B Kinase {beta}. Cancer Res 70 (4):1419-1429
-
(2010)
Cancer Res
, vol.70
, Issue.4
, pp. 1419-1429
-
-
Chatterjee, A.1
-
55
-
-
13944255793
-
RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage
-
Fomenkov A et al (2004) RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle 3 (10):1285-1295
-
(2004)
Cell Cycle
, vol.3
, Issue.10
, pp. 1285-1295
-
-
Fomenkov, A.1
-
56
-
-
82455209036
-
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage
-
Lazzari C et al (2011) HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage. Oncogene 30(48):4802-4813
-
(2011)
Oncogene
, vol.30
, Issue.48
, pp. 4802-4813
-
-
Lazzari, C.1
-
57
-
-
33748065322
-
The E3 ubiquitin ligase Itch controls the protein stability of p63
-
Rossi M et al (2006) The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci USA 103 (34):12753-12758
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.34
, pp. 12753-12758
-
-
Rossi, M.1
-
58
-
-
33748585368
-
Itch/AIP4 associates with and promotes p63 protein degradation
-
Rossi M et al (2006) Itch/AIP4 associates with and promotes p63 protein degradation. Cell Cycle 5(16):1816-1822
-
(2006)
Cell Cycle
, vol.5
, Issue.16
, pp. 1816-1822
-
-
Rossi, M.1
-
59
-
-
79951687016
-
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer
-
Deutsch GB et al (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 144(4):566-576
-
(2011)
Cell
, vol.144
, Issue.4
, pp. 566-576
-
-
Deutsch, G.B.1
-
60
-
-
0032744735
-
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
-
Celli J et al (1999) Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 99(2):143-153
-
(1999)
Cell
, vol.99
, Issue.2
, pp. 143-153
-
-
Celli, J.1
-
61
-
-
0035253507
-
Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63
-
McGrath JA et al (2001) Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet 10(3):221-229
-
(2001)
Hum Mol Genet
, vol.10
, Issue.3
, pp. 221-229
-
-
McGrath, J.A.1
-
62
-
-
0037108134
-
P63 gene mutations and human developmental syndromes
-
Brunner HG, Hamel BCJ, van Bokhoven H (2002) P63 gene mutations and human developmental syndromes. Am J Med Genet 112(3):284-290
-
(2002)
Am J Med Genet
, vol.112
, Issue.3
, pp. 284-290
-
-
Brunner, H.G.1
Hamel, B.2
Van Bokhoven, H.3
-
63
-
-
0036096302
-
Mutations in the p53 homolog p63: Allele-specific developmental syndromes in humans
-
van Bokhoven H, McKeon F (2002) Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol Med 8(3):133-139
-
(2002)
Trends Mol Med
, vol.8
, Issue.3
, pp. 133-139
-
-
Van Bokhoven, H.1
McKeon, F.2
-
64
-
-
33746363208
-
Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene
-
Rinne T et al (2006) Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene. Eur J Hum Genet 14(8):904-910
-
(2006)
Eur J Hum Genet
, vol.14
, Issue.8
, pp. 904-910
-
-
Rinne, T.1
-
65
-
-
34247511981
-
P63 Is essential for the proliferative potential of stem cells in stratified epithelia
-
Senoo M et al (2007) p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129(3):523-536
-
(2007)
Cell
, vol.129
, Issue.3
, pp. 523-536
-
-
Senoo, M.1
-
66
-
-
85040650754
-
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
-
Shalom-Feuerstein R et al (2010) ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ
-
(2010)
Cell Death Differ
-
-
Shalom-Feuerstein, R.1
-
67
-
-
33646797744
-
Differential roles of p63 isoforms in epidermal development: Selective genetic complementation in p63 null mice
-
Candi E et al (2006) Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ 13(6):1037-1047
-
(2006)
Cell Death Differ
, vol.13
, Issue.6
, pp. 1037-1047
-
-
Candi, E.1
-
68
-
-
33645894992
-
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
-
Nguyen B-C et al (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 20 (8):1028-1042
-
(2006)
Genes Dev
, vol.20
, Issue.8
, pp. 1028-1042
-
-
Nguyen, B.-C.1
-
69
-
-
85040706723
-
ΔNp63α and tap63α regulate transcription of genes with distinct biological functions in cancer and development
-
Wu G et al. ΔNp63α and tap63α regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res
-
Cancer Res
-
-
Wu, G.1
-
70
-
-
67649159970
-
TAp63 prevents premature aging by promoting adult stem cell maintenance
-
Su X et al (2009) TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75
-
(2009)
Cell Stem Cell
, vol.5
, Issue.1
, pp. 64-75
-
-
Su, X.1
-
71
-
-
0034702133
-
P51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation
-
Katoh I et al (2000) p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Oncogene 19(27):3126-3130
-
(2000)
Oncogene
, vol.19
, Issue.27
, pp. 3126-3130
-
-
Katoh, I.1
-
72
-
-
33750378033
-
Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma
-
DeYoung MP et al (2006) Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma. Cancer Res 66(19):9362-9368
-
(2006)
Cancer Res
, vol.66
, Issue.19
, pp. 9362-9368
-
-
Deyoung, M.P.1
-
73
-
-
33751230475
-
P63 regulates proliferation and differentiation of developmentally mature keratinocytes
-
Truong AB et al (2006) p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 20 (22):3185-3197
-
(2006)
Genes Dev
, vol.20
, Issue.22
, pp. 3185-3197
-
-
Truong, A.B.1
-
74
-
-
77951093434
-
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells
-
Antonini D et al (2010) Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J Invest Dermatol 130(5):1249-1257
-
(2010)
J Invest Dermatol
, vol.130
, Issue.5
, pp. 1249-1257
-
-
Antonini, D.1
-
75
-
-
24344447780
-
P63 deficiency activates a program of cellular senescence and leads to accelerated aging
-
Keyes WM et al (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19 (17):1986-1999
-
(2005)
Genes Dev
, vol.19
, Issue.17
, pp. 1986-1999
-
-
Keyes, W.M.1
-
76
-
-
73349088166
-
TAp63 induces senescence and suppresses tumorigenesis in vivo
-
Guo X et al (2009) TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol 11(12):1451-1457
-
(2009)
Nat Cell Biol
, vol.11
, Issue.12
, pp. 1451-1457
-
-
Guo, X.1
-
77
-
-
17444390129
-
Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
-
Flores ER et al (2005) Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 7(4):363-373
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 363-373
-
-
Flores, E.R.1
-
78
-
-
33744830912
-
P63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
-
Keyes WM et al (2006) p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci USA 103(22):8435-8440
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.22
, pp. 8435-8440
-
-
Keyes, W.M.1
-
79
-
-
0033199888
-
Mutational analysis of the p63/p73L/ p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers
-
Hagiwara K et al (1999) Mutational analysis of the p63/p73L/ p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. Cancer Res 59(17):4165-4169
-
(1999)
Cancer Res
, vol.59
, Issue.17
, pp. 4165-4169
-
-
Hagiwara, K.1
-
80
-
-
0033600126
-
Mutational analysis of p51A/TAp63- gamma, a p53 homolog, in non-small cell lung cancer and breast cancer
-
Sunahara M et al (1999) Mutational analysis of p51A/TAp63- gamma, a p53 homolog, in non-small cell lung cancer and breast cancer. Oncogene 18(25):3761-3765
-
(1999)
Oncogene
, vol.18
, Issue.25
, pp. 3761-3765
-
-
Sunahara, M.1
-
81
-
-
0344734060
-
DNA gains in 3q occur frequently in squamous cell carcinoma of the lung, but not in adenocarcinoma
-
Björkqvist AM et al (1998) DNA gains in 3q occur frequently in squamous cell carcinoma of the lung, but not in adenocarcinoma. Genes Chromosomes Canc 22(1):79-82
-
(1998)
Genes Chromosomes Canc
, vol.22
, Issue.1
, pp. 79-82
-
-
Björkqvist, A.M.1
-
82
-
-
0034625043
-
AIS is an oncogene amplified in squamous cell carcinoma
-
Hibi K et al (2000) AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci USA 97(10):5462-5467
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.10
, pp. 5462-5467
-
-
Hibi, K.1
-
83
-
-
10744221856
-
Significance of p63 amplification and overexpression in lung cancer development and prognosis
-
Massion PP et al (2003) Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res 63(21):7113-7121
-
(2003)
Cancer Res
, vol.63
, Issue.21
, pp. 7113-7121
-
-
Massion, P.P.1
-
84
-
-
10044266819
-
Dominant negative p63 isoform expression in head and neck squamous cell carcinoma
-
Sniezek JC et al (2004) Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. Laryngoscope 114(12):2063-2072
-
(2004)
Laryngoscope
, vol.114
, Issue.12
, pp. 2063-2072
-
-
Sniezek, J.C.1
-
85
-
-
0037146761
-
Elevated expression of p63 protein in human esophageal squamous cell carcinomas
-
Hu H et al (2002) Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int J Cancer 102(6):580-583
-
(2002)
Int J Cancer
, vol.102
, Issue.6
, pp. 580-583
-
-
Hu, H.1
-
86
-
-
0034986554
-
Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: A study of 250 cases
-
Wang TY et al (2001) Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol 32 (5):479-486
-
(2001)
Hum Pathol
, vol.32
, Issue.5
, pp. 479-486
-
-
Wang, T.Y.1
-
87
-
-
27644567107
-
P63, cytokeratin 5, and P-cadherin: Three molecular markers to distinguish basal phenotype in breast carcinomas
-
Matos I et al (2005) p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch 447(4):688-694
-
(2005)
Virchows Arch
, vol.447
, Issue.4
, pp. 688-694
-
-
Matos, I.1
-
88
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752
-
(2000)
Nature
, vol.406
, Issue.6797
, pp. 747-752
-
-
Perou, C.M.1
-
89
-
-
34248166978
-
The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers
-
Leong C-O et al (2007) The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. J Clin Invest 117(5):1370-1380
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1370-1380
-
-
Leong, C.-O.1
-
90
-
-
79959883295
-
Physical Association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma
-
Ramsey MR et al (2011) Physical Association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res 71 (13):4373-4379
-
(2011)
Cancer Res
, vol.71
, Issue.13
, pp. 4373-4379
-
-
Ramsey, M.R.1
-
91
-
-
13444250890
-
DeltaNp63alpha up-regulates the Hsp70 gene in human cancer
-
Wu G et al (2005) DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. Cancer Res 65(3):758-766
-
(2005)
Cancer Res
, vol.65
, Issue.3
, pp. 758-766
-
-
Wu, G.1
-
92
-
-
79551607574
-
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
-
Keyes WM et al (2011) ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 8(2):164-176
-
(2011)
Cell Stem Cell
, vol.8
, Issue.2
, pp. 164-176
-
-
Keyes, W.M.1
-
93
-
-
21344449113
-
The transactivating isoforms of p63 are overexpressed in high-grade follicular lymphomas independent of the occurrence of p63 gene amplification
-
Pruneri G et al (2005) The transactivating isoforms of p63 are overexpressed in high-grade follicular lymphomas independent of the occurrence of p63 gene amplification. J Pathol 206(3):337-345
-
(2005)
J Pathol
, vol.206
, Issue.3
, pp. 337-345
-
-
Pruneri, G.1
-
94
-
-
0035167503
-
Expression of the p53 homologue p63 in early cervical neoplasia
-
Quade BJ et al (2001) Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol 80(1):24-29
-
(2001)
Gynecol Oncol
, vol.80
, Issue.1
, pp. 24-29
-
-
Quade, B.J.1
-
95
-
-
1842536143
-
P63 expression in benign and malignant breast lesions
-
Stefanou D et al (2004) p63 expression in benign and malignant breast lesions. Histol Histopathol 19(2):465-471
-
(2004)
Histol Histopathol
, vol.19
, Issue.2
, pp. 465-471
-
-
Stefanou, D.1
-
96
-
-
0036368628
-
P63 expression in normal, hyperplastic and malignant breast tissues
-
Wang X et al (2002) p63 expression in normal, hyperplastic and malignant breast tissues. Breast Cancer 9(3):216-219
-
(2002)
Breast Cancer
, vol.9
, Issue.3
, pp. 216-219
-
-
Wang, X.1
-
97
-
-
0345189361
-
Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder
-
Koga F et al (2003) Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Clin Cancer Res 9(15):5501-5507
-
(2003)
Clin Cancer Res
, vol.9
, Issue.15
, pp. 5501-5507
-
-
Koga, F.1
-
98
-
-
0037430057
-
Impaired Delta Np63 expression associates with reduced beta-catenin and aggressive phenotypes of urothelial neoplasms
-
Koga F et al (2003) Impaired Delta Np63 expression associates with reduced beta-catenin and aggressive phenotypes of urothelial neoplasms. Br J Cancer 88(5):740-747
-
(2003)
Br J Cancer
, vol.88
, Issue.5
, pp. 740-747
-
-
Koga, F.1
-
99
-
-
0036791603
-
Loss of p63 expression is associated with tumor progression in bladder cancer
-
Urist MJ et al (2002) Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol 161 (4):1199-1206
-
(2002)
Am J Pathol
, vol.161
, Issue.4
, pp. 1199-1206
-
-
Urist, M.J.1
-
100
-
-
0043244946
-
Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression
-
Vanaja DK et al (2003) Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. Cancer Res 63(14):3877-3882
-
(2003)
Cancer Res
, vol.63
, Issue.14
, pp. 3877-3882
-
-
Vanaja, D.K.1
-
101
-
-
20944437231
-
The gene expression signatures of melanoma progression
-
Haqq C et al (2005) The gene expression signatures of melanoma progression. Proc Natl Acad Sci USA 102(17):6092-6097
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.17
, pp. 6092-6097
-
-
Haqq, C.1
-
102
-
-
0041742257
-
Gene expression analysis of esophageal squamous cell carcinoma reveals consistent molecular profiles related to a family history of upper gastrointestinal cancer
-
Su H et al (2003) Gene expression analysis of esophageal squamous cell carcinoma reveals consistent molecular profiles related to a family history of upper gastrointestinal cancer. Cancer Res 63 (14):3872-3876
-
(2003)
Cancer Res
, vol.63
, Issue.14
, pp. 3872-3876
-
-
Su, H.1
-
103
-
-
77958558613
-
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
-
Su X et al (2010) TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 467(7318):986-990
-
(2010)
Nature
, vol.467
, Issue.7318
, pp. 986-990
-
-
Su, X.1
-
104
-
-
72249100428
-
Mutant p53 drives invasion by promoting integrin recycling
-
Muller PAJ et al (2009) Mutant p53 drives invasion by promoting integrin recycling. Cell 139(7):1327-1341
-
(2009)
Cell
, vol.139
, Issue.7
, pp. 1327-1341
-
-
Muller, P.1
-
105
-
-
63049136592
-
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
-
Adorno M et al (2009) A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 137(1):87-98
-
(2009)
Cell
, vol.137
, Issue.1
, pp. 87-98
-
-
Adorno, M.1
-
106
-
-
73649132320
-
Loss of DeltaNp63alpha promotes invasion of urothelial carcinomas via N-cadherin/Src homology and collagen/extracellular signal-regulated kinase pathway
-
Fukushima H et al (2009) Loss of DeltaNp63alpha promotes invasion of urothelial carcinomas via N-cadherin/Src homology and collagen/extracellular signal-regulated kinase pathway. Cancer Res 69(24):9263-9270
-
(2009)
Cancer Res
, vol.69
, Issue.24
, pp. 9263-9270
-
-
Fukushima, H.1
-
107
-
-
65649123009
-
DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma
-
Higashikawa K et al (2009) DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. Int J Cancer 124(12):2837-2844
-
(2009)
Int J Cancer
, vol.124
, Issue.12
, pp. 2837-2844
-
-
Higashikawa, K.1
-
108
-
-
70350029759
-
Regulation of VDR by {Delta}Np63 {alpha} is associated with inhibition of cell invasion
-
Kommagani R et al (2009) Regulation of VDR by {Delta}Np63 {alpha} is associated with inhibition of cell invasion. J Cell Sci
-
(2009)
J Cell Sci
-
-
Kommagani, R.1
-
109
-
-
17644381260
-
Perp is a p63-regulated gene essential for epithelial integrity
-
Ihrie RA et al (2005) Perp is a p63-regulated gene essential for epithelial integrity. Cell 120(6):843-856
-
(2005)
Cell
, vol.120
, Issue.6
, pp. 843-856
-
-
Ihrie, R.A.1
-
110
-
-
81155137696
-
ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization
-
Leonard MK et al (2011) ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ
-
(2011)
Cell Death Differ
-
-
Leonard, M.K.1
-
111
-
-
79960039752
-
A Pin1/Mutant p53 axis promotes aggressiveness in breast cancer
-
Girardini JE et al (2011) A Pin1/Mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell 20(1):79-91
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 79-91
-
-
Girardini, J.E.1
|