Δnp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

Cell Death and Differentiation

Volumn 18, Issue 12, 2011, Pages 1924-1933

  Leonard, M K ^a   Kommagani, R ^a   Payal, V ^a   Mayo, L D ^b   Shamma, H N ^a,c   Kadakia, M P ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Dermatopathology Laboratory of Central States   (United States)

Author keywords

Akt; keratinocytes; p63; PTEN; skin cancer

Indexed keywords

DELTANP63ALPHA PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN P63; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL GROWTH; CELL PROLIFERATION; ENZYME ACTIVATION; EPIDERMIS; FEEDBACK SYSTEM; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN CANCER; UPREGULATION;

ANIMALS; BASE SEQUENCE; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MICE; MOLECULAR SEQUENCE DATA; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RESPONSE ELEMENTS; SKIN; SKIN NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 81155137696     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.73     Document Type: Article

References (40)

1. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398: 708-713. (Pubitemid 29197649)
2. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominantnegative activities. Mol Cell 1998; 2: 305-316. (Pubitemid 128379271)
3. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002; 416: 560-564. (Pubitemid 34288861)
4. Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 2003; 23: 2264-2276. (Pubitemid 36351010)
5. Barbieri CE, Perez CA, Johnson KN, Ely KA, Billheimer D, Pietenpol JA. IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. Cancer Res 2005; 65: 2314-2320. (Pubitemid 40490141)
6. Wu G, Osada M, Guo Z, Fomenkov A, Begum S, Zhao M et al. DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. Cancer Res 2005; 65: 758-766. (Pubitemid 40216433)
7. Choi HR, Batsakis JG, Zhan F, Sturgis E, Luna MA, El-Naggar AK. Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. Hum Pathol 2002; 33: 158-164. (Pubitemid 34298729)
8. Sniezek JC,Matheny KE, WestfallMD, Pietenpol JA. Dominant negative p63 isoformexpression in head and neck squamous cell carcinoma. Laryngoscope 2004; 114: 2063-2072.
9. Ogawa E, Okuyama R, Ikawa S, Nagoshi H, Egawa T, Kurihara A et al. p51/p63 inhibits ultraviolet B-induced apoptosis via Akt activation. Oncogene 2007; 27: 848-856. (Pubitemid 351186320)
10. Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H et al. Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 2006; 25: 1174-1185.
11. Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U et al. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol 2000; 156: 1693-1700. (Pubitemid 30646707)
12. Whiteman DC, Zhou XP, Cummings MC, Pavey S, Hayward NK, Eng C. Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer 2002; 99: 63-67. (Pubitemid 34273199)
13. Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, YungWK. Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 2005; 25: 6211-6224. (Pubitemid 40946569)
14. Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y et al. Regulation of PTEN transcription by p53. Mol Cell 2001; 8: 317-325. (Pubitemid 32831549)
15. Di Como CJ, Urist MJ, Babayan I, Drobnjak M, Hedvat CV, Teruya-Feldstein J et al. p63 expression profiles in human normal and tumor tissues. Clin Cancer Res 2002; 8: 494-501. (Pubitemid 34193969)
16. Mangiulli M, Valletti A, Caratozzolo MF, Tullo A, Sbisa E, Pesole G et al. Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res 2009; 37: 6092-6104.
17. Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A et al. Subtle variations in Pten dose determine cancer susceptibility. Nat Genet 2010; 42: 454-458.
18. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999; 398: 714-718. (Pubitemid 29197650)
19. Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell 2006; 9: 45-56. (Pubitemid 43069510)
20. Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A et al. Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. J Biol Chem 2002; 277: 18817-18826. (Pubitemid 34952441)
21. Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001; 21: 1874-1887. (Pubitemid 32156407)
22. Rolley N, Butcher S, Milner J. Specific DNA binding by different classes of human p53 mutants. Oncogene 1995; 11: 763-770.
23. Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J et al. Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res 2007; 67: 11054-11063. (Pubitemid 350145936)
24. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 1999; 113: 1099-1105. (Pubitemid 30013359)
25. Sakiz D, Turkmenoglu TT, Kabukcuoglu F. The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin. Pathol Res Pract 2009; 205: 589-594.
26. Luukko K, Ylikorkala A, Tiainen M, Makela TP. Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev 1999; 83: 187-190. (Pubitemid 29302094)
27. Suzuki A, Itami S, Ohishi M, Hamada K, Inoue T, Komazawa N et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 2003; 63: 674-681. (Pubitemid 36158147)
28. Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci USA 2006; 103: 1480-1485. (Pubitemid 43191191)
29. Vella V, Puppin C, Damante G, Vigneri R, Sanfilippo M, Vigneri P et al. DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells. Int J Cancer 2009; 124: 2539-2548.
30. Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y et al. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J 2009; 28: 21-33.
31. Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M et al. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 201; 144: 187-199.
32. Bolshakov S, Walker CM, Strom SS, Selvan MS, Clayman GL, El-Naggar A et al. p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. Clin Cancer Res 2003; 9: 228-234. (Pubitemid 36109738)
33. Giglia-Mari G, Sarasin A. TP53 mutations in human skin cancers. Hum Mutat 2003; 21: 217-228. (Pubitemid 36292964)
34. Kommagani R, Leonard MK, Lewis S, Romano RA, Sinha S, Kadakia MP. Regulation of VDR by deltaNp63alpha is associated with inhibition of cell invasion. J Cell Sci 2009; 122 (Part 16): 2828-2835.
35. Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 2001; 98: 11598-11603. (Pubitemid 32928774)
36. Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA et al. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol 2006; 8: 551-561. (Pubitemid 43827347)
37. Chiang CT, Chu WK, Chow SE, Chen JK. Overexpression of delta Np63 in a human nasopharyngeal carcinoma cell line downregulates CKIs and enhances cell proliferation. J Cell Physiol 2009; 219: 117-122.
38. Guittet O, Tebbi A, Cottet MH, Vesin F, Lepoivre M. Upregulation of the p53R2 ribonucleotide reductase subunit by nitric oxide. Nitric Oxide 2008; 19: 84-94.
39. Virolle T, Adamson ED, Baron V, Birle D, Mercola D, Mustelin T et al. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol 2001; 3: 1124-1128. (Pubitemid 33130464)
40. Romano RA, Birkaya B, Sinha S. A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63. J Invest Dermatol 2007; 127: 1175-1186. (Pubitemid 46625134)