TAp63 is a transcriptional target of NF-κB

Journal of Cellular Biochemistry

Volumn 109, Issue 4, 2010, Pages 702-710

  Wu, Junfeng ^a   Bergholz, Johann ^a   Lu, Jinin ^a   Sonenshein, Gail E ^a   Xiao, Zhi Xiong Jim ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cortical neuron; NF B; p53; p63; Sp1; Transcription

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN P50; PROTEIN P53; PROTEIN P63; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; BINDING SITE; BREAST EPITHELIUM; CANCER CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN HEK293; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; DNA PROTEIN COMPLEX; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION;

BINDING SITES; CELL LINE; HUMANS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 77749311480     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22449     Document Type: Article

References (57)

1. Akama KT, Albanese C, Pestell RG, Van Eldik LJ. 1998. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaBdependent mechanism. Proc Natl Acad Sci USA 95:5795-5800.
2. Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS. 2004. Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. J Neurosci 24:2963-2973.
3. Basile JR, Eichten A, Zacny V, Munger K. 2003. NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes. Mol Cancer Res 1:262-270.
4. Bhakar AL, Tannis LL, Zeindler C, Russo MP, Jobin C, Park DS, MacPherson S, Barker PA. 2002. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci 22:8466-8475.
5. Bian X, McAllister-Lucas LM, Shao F, Schumacher KR, Feng Z, Porter AG, Castle VP, Opipari AW, Jr. 2001. NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J Biol Chem 276:48921-48929.
6. Boekhoudt GH, Guo Z, Beresford GW, Boss JM. 2003. Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene. J Immunol 170:4139-4147.
7. Bours V, Bentires-Alj M, Hellin AC, Viatour P, Robe P, Delhalle S, Benoit V, Merville MP. 2000. Nuclear factor-kappa B, cancer, and apoptosis. Biochem Pharmacol 60:1085-1089.
8. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. 1995. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485-1488.
9. Brunner HG, Hamel BC, von Bokhoven H. 2002. P63 gene mutations and human developmental syndromes. Am J Med Genet 112:284-290.
10. Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, Smits AP, Newbury-Ecob R, Hennekam RC, Van Buggenhout G, van Haeringen A, Woods CG, van Essen AJ, de Waal R, Vriend G, Haber DA, Yang A, McKeon F, Brunner HG, van Bokhoven H. 1999. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 99:143-153.
11. Chan H, Bartos DP, Owen-Schaub LB. 1999. Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. Mol Cell Biol 19:2098-2108.
12. Dignam JD, Lebovitz RM, Roeder RG. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
13. Duckett CS, Perkins ND, Kowalik TF, Schmid RM, Huang ES, Baldwin AS, Jr., Nabel GJ. 1993. Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol Cell Biol 13:1315-1322.
14. Duyao MP, Buckler AJ, Sonenshein GE. 1990. Interaction of an NF-kappa Blike factor with a site upstream of the c-myc promoter. Proc Natl Acad Sci USA 87:4727-4731.
15. Goffi F, Boroni F, Benarese M, Sarnico I, Benetti A, Spano PF, Pizzi M. 2005. The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Neurosci Lett 377:147-151.
16. Gressner O, Schilling T, Lorenz K, Schulze Schleithoff E, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Muller M. 2005. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J 24:2458-2471.
17. Grilli M, Pizzi M, Memo M, Spano P. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383-1385.
18. Gveric D, Kaltschmidt C, Cuzner ML, Newcombe J. 1998. Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions. J Neuropathol Exp Neurol 57:168-178.
19. Hunot S, Brugg B, Ricard D, Michel PP, Muriel MP, Ruberg M, Faucheux BA, Agid Y, Hirsch EC. 1997. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease. Proc Natl Acad Sci USA 94:7531-7536.
20. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. 2005. p63 is an essential proapoptotic protein during neural development. Neuron 48:743-756.
21. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. 1997. Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94:2642-2647.
22. Kaltschmidt B, Widera D, Kaltschmidt C. 2005. Signaling via NF-kappaB in the nervous system. Biochim Biophys Acta 1745:287-299.
23. Katoh I, Aisaki KI, Kurata SI, Ikawa S, Ikawa Y. 2000. p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Oncogene 19:3126-3130.
24. Kirch HC, Flaswinkel S, Rumpf H, Brockmann D, Esche H. 1999. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max. Oncogene 18:2728-2738.
25. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. 2004. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 18:126-131.
26. Koster MI, Lu SL, White LD, Wang XJ, Roop DR. 2006. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res 66:3981-3986.
27. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. 2007. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci USA 104:3255-3260.
28. Kunisaki R, Ikawa S, Maeda T, Nakazaki Y, Kurita R, Harata M, Shutoh Y, Bai YS, Soda Y, Tanabe T, Dohi T, Kato R, Ikawa Y, Asano S, Tani K. 2006. p51/ p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate. J Gene Med 8:1121-1130.
29. Lantner F, Starlets D, Gore Y, Flaishon L, Yamit-Hezi A, Dikstein R, Leng L, Bucala R, Machluf Y, Oren M, Shachar I. 2007. CD74 induces TAp63 expression leading to B cell survival. Blood 110:4303-4311.
30. Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I. 2006. p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development 133:1553-1563.
31. N, Li H, Cherukuri P, Farzan S, Harmes DC, DiRenzo J. 2006. TA-p63-gamma regulates expression of DeltaN-p63 in a manner that is sensitive to p53. Oncogene 25:2349-2359.
32. Lin SC, Wortis HH, Stavnezer J. 1998. The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins. Mol Cell Biol 18:5523-5532.
33. MacPartlin M, Zeng SX, Lu H. 2008. Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta. J Biol Chem 283:15754-15761.
34. Mattson MP. 2005. NF-kappaB in the survival and plasticity of neurons. Neurochem Res 30:883-893.
35. Mikkola ML. 2007. p63 in skin appendage development. Cell Cycle 6:285-290.
36. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. 1999. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398:708-713.
37. Pazin MJ, Sheridan PL, Cannon K, Cao Z, Keck JG, Kadonaga JT, Jones KA. 1996. NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes Dev 10:37-49.
38. Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME. 1997. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272:21096-21103.
39. Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. 2006. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell 9:45-56.
40. Ryan KM, Ernst MK, Rice NR, Vousden KH. 2000. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404:892-897.
41. Sarnico I, Boroni F, Benarese M, Alghisi M, Valerio A, Battistin L, Spano P, Pizzi M. 2008. Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes. J Neural Transm 115:693-701.
42. Seitz CS, Lin Q, Deng H, Khavari PA. 1998. Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB. Proc Natl Acad Sci USA 95:2307-2312.
43. Seitz CS, Deng H, Hinata K, Lin Q, Khavari PA. 2000. Nuclear factor kappaB subunits induce epithelial cell growth arrest. Cancer Res 60:4085-4092.
44. Senoo M, Pinto F, Crum CP, McKeon F. 2007. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129:523-536.
45. Shin SR, Sanchez-Velar N, Sherr DH, Sonenshein GE. 2006. 7,12-dimethylbenz( a)anthracene treatment of a c-rel mouse mammary tumor cell line induces epithelial to mesenchymal transition via activation of nuclear factorkappaB. Cancer Res 66:2570-2575.
46. Sonenshein GE. 1997. Rel/NF-kappa B transcription factors and the control of apoptosis. Semin Cancer Biol 8:113-119.
47. Sovak MA, Bellas RE, Kim DW, Zanieski GJ, Rogers AE, Traish AM, Sonenshein GE. 1997. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100:2952-2960.
48. Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5:64-75.
49. Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F. 2006. p63 protects the female germ line during meiotic arrest. Nature 444:624-628.
50. Tamaki T, Ohnishi K, Hartl C, LeRoy EC, Trojanowska M. 1995. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the alpha 2(I) collagen gene in human fibroblasts. J Biol Chem 270:4299-4304.
51. Waltermann A, Kartasheva NN, Dobbelstein M. 2003. Differential regulation of p63 and p73 expression. Oncogene 22:5686-5693.
52. Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. 2002. N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 22:815-824.
53. Wu JT, Kral JG. 2005. The NF-kappaB/IkappaB signaling system: A molecular target in breast cancer therapy. J Surg Res 123:158-169.
54. Wu M, Lee H, Bellas RE, Schauer SL, Arsura M, Katz D, FitzGerald MJ, Rothstein TL, Sherr DH, Sonenshein GE. 1996. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J 15:4682-4690.
55. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F. 1998. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316.
56. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F. 1999. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714-718.
57. Zheng Y, Ouaaz F, Bruzzo P, Singh V, Gerondakis S, Beg AA. 2001. NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. J Immunol 166:4949-4957.