Regulation of VDR by ΔNp63α is associated with inhibition of cell invasion

Journal of Cell Science

Volumn 122, Issue 16, 2009, Pages 2828-2835

  Kommagani, Ramakrishna ^a   Leonard, Mary K ^a   Lewis, Stefanie ^a   Romano, Rose Anne ^b   Sinha, Satrajit ^b   Kadakia, Madhavi P ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Np63 ; Cell invasion; VDR

Indexed keywords

ISOPROTEIN; PROTEIN NP63ALPHA; PROTEIN P63; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; PHOSPHOPROTEIN; TP63 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; CANCER INVASION; CELL MOTION; DOWN REGULATION; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

MUS;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MICE; NEOPLASM INVASIVENESS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; RECEPTORS, CALCITRIOL; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 70350029759     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.049619     Document Type: Article

References (41)

1. Banerjee, P. and Chatterjee, M. (2003). Antiproliferative role of vitamin D and its analogs- a brief overview. Mol. Cell Biochem. 253, 247-254.
2. Barbieri, C. E., Perez, C. A., Johnson, K. N., Ely, K. A., Billheimer, D. and Pietenpol, J. A. (2005). IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. Cancer Res. 65, 2314-2320.
3. Barbieri, C. E., Tang, L. J., Brown, K. A. and Pietenpol, J. A. (2006). Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res. 66, 7589-7597.
4. Barrallo-Gimeno, A. and Nieto, M. A. (2005). The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132, 3151-3161.
5. Barrow, L. L., van Bokhoven, H., Daack-Hirsch, S., Andersen, T., van Beersum, S. E., Gorlin, R. and Murray, J. C. (2002). Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts. J. Med. Genet. 39, 559-566.
6. Bikle, D. D., Ng, D., Oda, Y., Hanley, K., Feingold, K. and Xie, Z. (2002). The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. J. Invest. Dermatol. 119, 1109-1113.
7. Candi, E., Dinsdale, D., Rufini, A., Salomoni, P., Knight, R. A., Mueller, M., Krammer, P. H. and Melino, G. (2007). TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle 6, 274-285.
8. Caserta, T. M., Kommagani, R., Yuan, Z., Robbins, D. J., Mercer, C. A. and Kadakia, M. P. (2006). p63 overexpression induces the expression of Sonic Hedgehog. Mol. Cancer Res. 4, 759-768.
9. Cianferotti, L., Cox, M., Skorija, K. and Demay, M. B. (2007). Vitamin D receptor is essential for normal keratinocyte stem cell function. Proc. Natl. Acad. Sci. USA 104, 9428-9433.
10. Ellison, T. I., Eckert, R. L. and MacDonald, P. N. (2007). Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes. J. Biol. Chem. 282, 10953-10962.
11. Hawker, N. P., Pennypacker, S. D., Chang, S. M. and Bikle, D. D. (2007). Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J. Invest. Dermatol. 127, 874-880.
12. Helton, E. S., Zhu, J. and Chen, X. (2006). The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J. Biol. Chem. 281, 2533-2542.
13. Higashikawa, K., Yoneda, S., Tobiume, K., Taki, M., Shigeishi, H. and Kamata, N. (2007). Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma. Cancer Res. 67, 9207-9213.
14. Hu, H., Xia, S. H., Li, A. D., Xu, X., Cai, Y., Han, Y. L., Wei, F., Chen, B. S., Huang, X. P., Han, Y. S. et al. (2002). Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int. J. Cancer 102, 580-583.
15. Khokhar, S. K., Kommagani, R. and Kadakia, M. P. (2008). Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes. Cell Res. 18, 1061-1073.
16. Kommagani, R., Caserta, T. M. and Kadakia, M. P. (2006). Identification of vitamin D receptor as a target of p63. Oncogene 25, 3745-3751.
17. Kommagani, R., Payal, V. and Kadakia, M. P. (2007). Differential regulation of vitamin D receptor (VDR) by the p53 family: p73-dependent induction of VDR upon DNA damage. J. Biol. Chem. 282, 29847-29854.
18. Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J. and Roop, D. R. (2004). p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18, 126-131.
19. Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R. and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-713.
20. Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M. et al. (1998). Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4, 839-843.
21. Palmer, H. G., Gonzalez-Sancho, J. M., Espada, J., Berciano, M. T., Puig, I., Baulida, J., Quintanilla, M., Cano, A., de Herreros, A. G., Lafarga, M. et al. (2001). Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J. Cell Biol. 154, 369-387.
22. Palmer, H. G., Larriba, M. J., Garcia, J. M., Ordonez-Moran, P., Pena, C., Peiro, S., Puig, I., Rodriguez, R., de la Fuente, R., Bernad, A. et al. (2004). The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat. Med. 10, 917-919.
23. Park, H. R., Kim, Y. W., Park, J. H., Maeng, Y. H., Nojima, T., Hashimoto, H. and Park, Y. K. (2004). Low expression of p63 and p73 in osteosarcoma. Tumori 90, 239-243.
24. Parsons, J. K., Gage, W. R., Nelson, W. G. and De Marzo, A. M. (2001). p63 protein expression is rare in prostate adenocarcinoma: implications for cancer diagnosis and carcinogenesis. Urology 58, 619-624.
25. Pena, C., Garcia, J. M., Silva, J., Garcia, V., Rodriguez, R., Alonso, I., Millan, I., Salas, C., de Herreros, A. G., Munoz, A. et al. (2005). E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum. Mol. Genet. 14, 3361-3370.
26. Petitjean, A., Ruptier, C., Tribollet, V., Hautefeuille, A., Chardon, F., Cavard, C., Puisieux, A., Hainaut, P. and Caron de Fromentel, C. (2008). Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73. Carcinogenesis 29, 273-281.
27. Romano, R. A., Birkaya, B. and Sinha, S. (2006). Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: potential roles for Sp1/Sp3, NFY, and p63. J. Invest. Dermatol. 126, 1469-1479.
28. Senoo, M., Matsumura, Y. and Habu, S. (2002). TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression. Oncogene 21, 2455-2465.
29. Senoo, M., Pinto, F., Crum, C. P. and McKeon, F. (2007). p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129, 523-536.
30. Shimada, A., Kato, S., Enjo, K., Osada, M., Ikawa, Y., Kohno, K., Obinata, M., Kanamaru, R., Ikawa, S. and Ishioka, C. (1999). The transcriptional activities of p53 and its homologue p51/p63: similarities and differences. Cancer Res. 59, 2781-2786.
31. Sniezek, J. C., Matheny, K. E., Westfall, M. D. and Pietenpol, J. A. (2004). Dominant negative p63 isoform expression in head and neck squamous cell carcinoma. Laryngoscope 114, 2063-2072.
32. Spiesbach, K., Tannapfel, A., Mossner, J. and Engeland, K. (2005). TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor. Int. J. Cancer 114, 555-562.
33. Tokar, E. J. and Webber, M. M. (2005). Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Clin. Exp. Metastasis 22, 275-284.
34. Urist, M. J., Di Como, C. J., Lu, M. L., Charytonowicz, E., Verbel, D., Crum, C. P., Ince, T. A., McKeon, F. D. and Cordon-Cardo, C. (2002). Loss of p63 expression is associated with tumor progression in bladder cancer. Am. J. Pathol. 161, 1199-1206.
35. van Bokhoven, H. and McKeon, F. (2002). Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol. Med. 8, 133-139.
36. van Bokhoven, H., Hamel, B. C., Bamshad, M., Sangiorgi, E., Gurrieri, F., Duijf, P. H., Vanmolkot, K. R., van Beusekom, E., van Beersum, S. E., Celli, J. et al. (2001). p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split handsplit foot malformation suggest a genotype-phenotype correlation. Am. J. Hum. Genet. 69, 481-492.
37. Westfall, M. D., Mays, D. J., Sniezek, J. C. and Pietenpol, J. A. (2003). The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol. Cell. Biol. 23, 2264-2276.
38. Wu, G., Osada, M., Guo, Z., Fomenkov, A., Begum, S., Zhao, M., Upadhyay, S., Xing, M., Wu, F., Moon, C. et al. (2005). DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. Cancer Res. 65, 758-766.
39. Xie, Z., Komuves, L., Yu, Q. C., Elalieh, H., Ng, D. C., Leary, C., Chang, S., Crumrine, D., Yoshizawa, T., Kato, S. et al. (2002). Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J. Invest. Dermatol. 118, 11-16.
40. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D. and McKeon, F. (1998). p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2, 305-316.
41. Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C., Sharpe, A., Caput, D., Crum, C. et al. (1999). p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398, 714-718.