Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 79-91

  Topham, Caroline H ^a   Billinton, Nicholas ^b   Walmsley, Richard M ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Gentronix Ltd   (United Kingdom)

Author keywords

Apoptosis; GADD45a; Genotoxicity; GreenScreen HC; Misleading positive; Screening; TK6

Indexed keywords

(6) GINGEROL; 2,5 BIS (5 HYDROXYMETHYL 2 THIENYL) FURAN; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CAFFEIC ACID DERIVATIVE; CASPASE 3; CASPASE 7; GREEN FLUORESCENT PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; I KAPPA B; LIGASE INHIBITOR; LIPOCORTIN 5; NAVITOCLAX; NSC 652287; NUTLIN 3; OBATOCLAX; OLIGOMYCIN; PIFITHRIN ALPHA; PROTEIN BCL 2; PROTEIN P53; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; STAUROSPORINE; UNCLASSIFIED DRUG; YC 137;

APOPTOSIS; ARTICLE; BINDING ASSAY; COMET ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDICAL SOCIETY; MICRONUCLEUS TEST; PROTEIN DETERMINATION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; GREEN FLUORESCENT PROTEINS; HUMANS; MUTAGENICITY TESTS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 84864153864     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs132     Document Type: Article

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