The prostacyclin agonist iloprost aggravates fibrosis and enhances viral replication in enteroviral myocarditis by modulation of ERK signaling and increase of iNOS expression

Basic Research in Cardiology

Volumn 107, Issue 5, 2012, Pages

  Gruhle, Stefan ^a   Sauter, Martina ^a   Szalay, Gudrun ^a,b   Ettischer, Nicole ^a   Kandolf, Reinhard ^a   Klingel, Karin ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

Author keywords

Coxsackievirus B3; CTGF; Fibrosis; Iloprost; INOS; Myocarditis

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; GAMMA INTERFERON; ILOPROST; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROCOLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE I, ALPHA 1 CHAIN; CTGF PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; NOS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL STIMULATION; CONTROLLED STUDY; COXSACKIE VIRUS B3; DISEASE EXACERBATION; ENZYME ACTIVATION; ENZYME REGULATION; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; INTRACELLULAR SIGNALING; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME; UPREGULATION; VIRUS MYOCARDITIS; VIRUS REPLICATION; ANIMAL; DRUG EFFECT; ENTEROVIRUS; ENTEROVIRUS INFECTION; FIBROSIS; GENETICS; HEART MUSCLE; METABOLISM; MOUSE; MYOCARDITIS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIROLOGY;

ANIMALS; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; ENTEROVIRUS B, HUMAN; ENTEROVIRUS INFECTIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROSIS; ILOPROST; MAP KINASE SIGNALING SYSTEM; MICE; MYOCARDITIS; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; VIRUS REPLICATION;

EID: 84864142244     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-012-0287-z     Document Type: Article

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