Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation

Journal of Molecular Medicine

Volumn 89, Issue 1, 2011, Pages 29-41

  Kuo, Chang Hung ^a,b,c   Ko, Ying Chin ^c,d,e   Yang, San Nan ^b,c,d   Chu, Yu Te ^b   Wang, Wei Li ^a,b   Huang, Shau Ku ^f   Chen, Huan Nan ^b   Wei, Wan Ju ^b   Jong, Yuh Jyh ^b,c,d   Hung, Chih Hsing ^a,b,c,d  

^a KAOHSIUNG MUNICIPAL TA TUNG HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Epigenetics; Interferon inducible protein 10; Macrophage derived chemokine; Monocytes; Prostaglandin I2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIC AMP; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B KINASE INHIBITOR; ILOPROST; LIPOPOLYSACCHARIDE; MACROPHAGE DERIVED CHEMOKINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RELA; UNIPROST; ANTIASTHMATIC AGENT; CHEMOKINE; DRUG DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; MITOGEN ACTIVATED PROTEIN KINASE; PROSTACYCLIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL EVALUATION; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ACTIVITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MONOCYTE; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; TREATMENT OUTCOME; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; IMMUNOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANTI-ASTHMATIC AGENTS; CELL LINE; CELLS, CULTURED; CHEMOKINES; CYCLIC AMP; EPIGENOMICS; EPOPROSTENOL; GENE EXPRESSION REGULATION; HUMANS; ILOPROST; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; TH1 CELLS; TH2 CELLS;

EID: 78651374332     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0694-2     Document Type: Article

References (34)

1. WW Busse RF Lemanske Jr 2001 Asthma N Engl J Med 344 350 362 1:CAS:528:DC%2BD3MXht1Wlu7k%3D 10.1056/NEJM200102013440507 11172168
2. JJ Smit NW Lukacs 2006 A closer look at chemokines and their role in asthmatic responses Eur J Pharmacol 533 277 288 1:CAS:528:DC%2BD28XitVKgs74%3D 10.1016/j.ejphar.2005.12.064 16464446
3. P Panina-Bordignon A Papi M Mariani P Di Lucia G Casoni C Bellettato C Buonsanti D Miotto C Mapp A Villa, et al. 2001 The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics J Clin Invest 107 1357 1364 1:CAS:528:DC%2BD3MXktFynt74%3D 10.1172/JCI12655 11390417
4. TF Leung GW Wong FW Ko CW Lam TF Fok 2004 Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma Clin Exp Allergy 34 786 791 1:CAS:528:DC%2BD2cXltlCrsr0%3D 10.1111/j.1365-2222.2004. 1951.x 15144472
5. CH Hung CY Li YS Lai PC Hsu YM Hua KD Yang 2005 Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma Pediatr Allergy Immunol 16 306 309 10.1111/j.1399-3038.2005.00273.x 15943593
6. BD Medoff A Sauty AM Tager JA Maclean RN Smith A Mathew JH Dufour AD Luster 2002 IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma J Immunol 168 5278 5286 1:CAS:528:DC%2BD38XjslSjtbs%3D 11994485
7. PA Wark F Bucchieri SL Johnston PG Gibson L Hamilton J Mimica G Zummo ST Holgate J Attia A Thakkinstian, et al. 2007 IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations J Allergy Clin Immunol 120 586 593 1:CAS:528:DC%2BD2sXhtVSgsLfL 10.1016/j.jaci.2007.04.046 17628646
8. ST Lai CH Hung YM Hua SH Hsu YJ Jong JL Suen 2008 T-helper 1-related chemokines in the exacerbation of childhood asthma Pediatr Int 50 99 102 1:CAS:528:DC%2BD1cXktlOntL0%3D 10.1111/j.1442-200X.2007.02533.x 18279215
9. BS Bochner SA Hudson HQ Xiao MC Liu 2003 Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions J Allergy Clin Immunol 112 930 934 1:CAS:528:DC%2BD3sXpsl2rs78%3D 10.1016/j.jaci.2003.08.012 14610482
10. CE Reed DK Milton 2001 Endotoxin-stimulated innate immunity: a contributing factor for asthma J Allergy Clin Immunol 108 157 166 1:CAS:528:DC%2BD3MXmslWqsLs%3D 10.1067/mai.2001.116862 11496229
11. O Michel J Kips J Duchateau F Vertongen L Robert H Collet R Pauwels R Sergysels 1996 Severity of asthma is related to endotoxin in house dust Am J Respir Crit Care Med 154 1641 1646 1:STN:280:DyaK2s7isFaluw%3D%3D 8970348
12. M Guha N Mackman 2001 LPS induction of gene expression in human monocytes Cell Signal 13 85 94 1:CAS:528:DC%2BD3MXitVOmtb0%3D 10.1016/S0898-6568(00) 00149-2 11257452
13. DM Aronoff CM Peres CH Serezani MN Ballinger JK Carstens N Coleman BB Moore RS Peebles LH Faccioli M Peters-Golden 2007 Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities J Immunol 178 1628 1634 1:CAS:528:DC%2BD2sXntVGmsg%3D%3D 17237412
14. M Idzko H Hammad M van Nimwegen M Kool N Vos HC Hoogsteden BN Lambrecht 2007 Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function J Clin Invest 117 464 472 1:CAS:528: DC%2BD2sXhs1Oqtrc%3D 10.1172/JCI28949 17273558
15. CH Hung YT Chu JL Suen MS Lee HW Chang YC Lo YJ Jong 2009 Regulation of cytokine expression in human plasmacytoid dendritic cells by prostaglandin I2 analogues Eur Respir J 33 405 410 1:CAS:528:DC%2BD1MXjvFOmtbw%3D 10.1183/09031936.00070008 19181914
16. SL Berger 2007 The complex language of chromatin regulation during transcription Nature 447 407 412 1:CAS:528:DC%2BD2sXlsFOgsrc%3D 10.1038/nature05915 17522673
17. K Ito G Caramori S Lim T Oates KF Chung PJ Barnes IM Adcock 2002 Expression and activity of histone deacetylases in human asthmatic airways Am J Respir Crit Care Med 166 392 396 10.1164/rccm.2110060 12153977
18. BG Cosio B Mann K Ito E Jazrawi PJ Barnes KF Chung IM Adcock 2004 Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma Am J Respir Crit Care Med 170 141 147 10.1164/rccm.200305- 659OC 15087294
19. PJ Barnes IM Adcock K Ito 2005 Histone acetylation and deacetylation: importance in inflammatory lung diseases Eur Respir J 25 552 563 1:CAS:528:DC%2BD2MXivVymu7g%3D 10.1183/09031936.05.00117504 15738302
20. DS Straus CK Glass 2007 Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms Trends Immunol 28 551 558 1:CAS:528:DC%2BD2sXhtlajtrfO 10.1016/j.it.2007.09.003 17981503
21. CH Hung JL Suen YM Hua W Chiang HC Chang CN Chen YJ Jong 2007 Suppressive effects of ketotifen on Th1- and Th2-related chemokines of monocytes Pediatr Allergy Immunol 18 378 384 10.1111/j.1399-3038.2007.00535.x 17617806
22. CH Hung SN Yang PL Kuo YT Chu HW Chang WJ Wei SK Huang YJ Jong 2010 Modulation of cytokine expression in human myeloid dendritic cells by environmental endocrine-disrupting chemicals involves epigenetic regulation Environ Health Perspect 118 67 72 1:CAS:528:DC%2BC3cXhsVSis7g%3D 10.1289/ehp.118-a67 20056579
23. J Fan NM Heller M Gorospe U Atasoy C Stellato 2005 The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy Eur Respir J 26 933 947 1:CAS:528:DC%2BD2MXht1KrtbvF 10.1183/09031936.05.00120204 16264057
24. E Poole E Atkins T Nakayama O Yoshie I Groves A Alcami J Sinclair 2008 NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86 J Virol 82 4250 4256 1:CAS:528:DC%2BD1cXltVOmtr4%3D 10.1128/JVI.02156-07 18287226
25. S Majumder LZ Zhou P Chaturvedi G Babcock S Aras RM Ransohoff 1998 Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines J Neurosci Res 54 169 180 1:CAS:528:DyaK1cXmsFCnsLY%3D 10.1002/(SICI)1097-4547(19981015)54:2<169::AID-JNR5>3.0.CO;2-C 9788276
26. AB Carter KL Knudtson MM Monick GW Hunninghake 1999 The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP) J Biol Chem 274 30858 30863 1:CAS:528:DyaK1MXntVSmtbY%3D 10.1074/jbc.274.43.30858 10521478
27. B Li M Carey JL Workman 2007 The role of chromatin during transcription Cell 128 707 719 1:CAS:528:DC%2BD2sXis12ju7c%3D 10.1016/j.cell.2007.01.015 17320508
28. W Zhou K Hashimoto K Goleniewska JF O'Neal S Ji TS Blackwell GA Fitzgerald KM Egan MW Geraci RS Peebles Jr 2007 Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells J Immunol 178 702 710 1:CAS:528:DC%2BD2sXhvVWqsw%3D%3D 17202330
29. Z Jaffar ME Ferrini MC Buford GA Fitzgerald K Roberts 2007 Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma J Immunol 179 6193 6203 1:CAS:528:DC%2BD2sXhtFyksrzM 17947695
30. K Nagao H Tanaka M Komai T Masuda S Narumiya H Nagai 2003 Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice Am J Respir Cell Mol Biol 29 314 320 1:CAS:528:DC%2BD3sXntFynur4%3D 10.1165/rcmb.2003-0035OC 12676807
31. H Ghadially XL Ross C Kerst J Dong AB Reske-Kunz R Ross 2005 Differential regulation of CCL22 gene expression in murine dendritic cells and B cells J Immunol 174 5620 5629 1:CAS:528:DC%2BD2MXjsVeru74%3D 15843561
32. SY Roth JM Denu CD Allis 2001 Histone acetyltransferases Annu Rev Biochem 70 81 120 1:CAS:528:DC%2BD3MXlsVehtrc%3D 10.1146/annurev.biochem.70.1.81 11395403
33. M Gomberg-Maitland H Olschewski 2008 Prostacyclin therapies for the treatment of pulmonary arterial hypertension Eur Respir J 31 891 901 1:CAS:528:DC%2BD1cXlsFyjsL0%3D 10.1183/09031936.00097107 18378784
34. LH Clapp P Finney S Turcato S Tran LJ Rubin A Tinker 2002 Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery Am J Respir Cell Mol Biol 26 194 201 1:CAS:528:DC%2BD38Xht1OjtrY%3D 11804870