Arsenic trioxide induces abnormal mitotic spindles through a PIP4KIIγ/Rho pathway

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 115-125

  Yih, Ling Huei ^a   Wu, Yi Chen ^a   Hsu, Nai Chi ^a   Kuo, Hsiao Hui ^a  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Apoptosis; Arsenic trioxide; Mitotic spindle; PIP4KII ; Rho

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ARSENIC TRIOXIDE; ISOPROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 5 PHOSPHATE 4 KINASE TYPE 2 GAMMA; PHOSPHOLIPASE C GAMMA1; PLECKSTRIN; PROTEIN KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CENTROSOME; CONTROLLED STUDY; DRUG DISTRIBUTION; ENZYME SYNTHESIS; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; PROTEIN ANALYSIS;

ARSENICALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GTP PHOSPHOHYDROLASES; HUMANS; MITOTIC SPINDLE APPARATUS; OXIDES; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84864138757     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs129     Document Type: Article

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