Development and validation of a LC-MS/MS method based on a new 96-well Hybrid-SPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 8, 2011, Pages 2371-2381

  Ardjomand Woelkart, Karin ^a   Kollroser, Manfred ^b   Li, Li ^c   Derendorf, Hartmut ^c   Butterweck, Veronika ^c   Bauer, Rudolf ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

CYP450; Hybrid SPE precipitation; Phospholipids; Validation

Indexed keywords

96-WELL; ANALYTES; ANALYTICAL TOOL; BIOANALYTICAL ASSAYS; CYP450; CYTOCHROME P450; DEXTROMETHORPHAN; DEXTRORPHAN; HIGH-THROUGHPUT; IN-VIVO; INTERNAL STANDARDS; LC-MS/MS; MIDAZOLAM; POSITIVE ION MODE; PRECIPITATION TECHNIQUES; RAT PLASMA; RELATIVE ERRORS; REVERSED PHASE LIQUID-CHROMATOGRAPHY; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRY; VALIDATION;

BODY FLUIDS; DEUTERIUM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHOSPHOLIPIDS; PLASMAS; PROBES; RATS;

DRUG INTERACTIONS;

CYTOCHROME P450; DRUG;

ANIMAL; ARTICLE; BLOOD; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; PRECIPITATION; RAT; SOLID PHASE EXTRACTION; SPRAGUE DAWLEY RAT; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

ANIMALS; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; MALE; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; SOLID PHASE EXTRACTION; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 79958139962     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4618-3     Document Type: Article

References (16)

1. J Lazarou BH Pomeranz PN Corey 1998 Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies JAMA 279 1200 1205 10.1001/jama.279.15.1200 1:STN:280:DyaK1c3hsFSnsQ%3D%3D (Pubitemid 28193431)
2. V Butterweck H Derendorf 2008 Potential of pharmacokinetic profiling for detecting herbal interactions with drugs Clin Pharmacokinet 47 383 397 10.2165/00003088-200847060-00003 1:CAS:528:DC%2BD1cXos1ehsro%3D (Pubitemid 351685388)
3. Boon H, Jurgens T (2001) Drug interactions with natural health products. Health Canada. Available at: http://www.hc-sc.gc.ca/dhp-mps/pubs/complement/ interaction-drug-medicament-11-01/index-e.html. Accessed 9 Apr 2008
4. S Zhang N Song Q Li H Fan C Liu 2008 Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats J Chromatogr B 871 78 89 10.1016/j.jchromb.2008.06.034 1:CAS:528:DC%2BD1cXpsVGnu70%3D
5. S Uchida H Yamada YD Li S Maruyama Y Ohmori T Oki H Watanabe K Umegaki K Ohashi S Yamada 2006 Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers J Clin Pharmacol 46 1290 1298 10.1177/0091270006292628 1:CAS:528:DC%2BD28Xht1WjsbzE (Pubitemid 44564357)
6. D Tomalik-Scharte A Jetter M Kinzig-Schippers A Skott F Sörgel T Klaassen D Kasel S Harlfinger O Doroshyenko D Frank J Kirchheiner M Bräter K Richter T Gramatte U Fuhr 2005 Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers Drug Metab Dispos 33 1859 1866 1:CAS:528:DC%2BD2MXht1ygu7nF (Pubitemid 41697272)
7. MC Jerdi Y Daali MK Oestreicher S Cherkaoui P Dayer 2004 A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes J Pharm Biomed 35 1203 1212 10.1016/j.jpba.2004.03.021 1:CAS:528:DC%2BD2cXntFSmtLs%3D (Pubitemid 39140285)
8. W Zhang F Han P Guo H Zhao Z Lin M-Q Huang K Bertelsen N Weng 2010 Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS-a high throughput approach to evaluate drug-drug interactions J Chromatogr B 878 1169 1177 10.1016/j.jchromb.2010.03.026 1:CAS:528:DC%2BC3cXlt1Cksbo%3D
9. Y-L Chen H Junga X Jiang W Naidong 2003 Simultaneous determination of theophylline, tolbutamide, mephenytoin, debrisoquin, and dapsone in human plasma using high-speed gradient liquid chromatography/tandem mass spectrometry on a silica-based monolitihic column J Sep Sci 26 1509 1519 10.1002/jssc.200301543 1:CAS:528:DC%2BD3sXpsVCrsrg%3D (Pubitemid 37483393)
10. Y Liu J Jiao C Zhang J Lou 2009 A simplifed method to determine five cytochrome P450 probe drugs by HPLC in a single run Biol Pharm Bull 32 717 720 10.1248/bpb.32.717 1:CAS:528:DC%2BD1MXmsVWksrs%3D
11. OQP Yin SSL Lam CMY Lo MSS Chow 2004 Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies Rapid Commun Mass Spectrom 18 2921 2933 10.1002/rcm.1704 1:CAS:528:DC%2BD2cXhtVOmtLfM (Pubitemid 39576836)
12. V Pucci S Di Palma A Alfieri F Monelli E Monteagudo 2009 A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE J Pharm Biomed Anal 50 867 871 10.1016/j.jpba.2009.05.037 1:CAS:528:DC%2BD1MXhtF2htL7P
13. FDA (2001) Guidance for industry: bioanalytical method validation. US Department of Health and Human Services FDA, Rockville
14. R Dams MA Huestis WE Lambert CM Murphy 2003 Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid J Am Soc Mass Spectrom 14 1290 1294 10.1016/S1044-0305(03)00574-9 1:CAS:528:DC%2BD3sXosVWqsbs%3D (Pubitemid 37330133)
15. M Nagata M Hidaka H Sekiya Y Kawano K Yamasaki M Okumura K Arimori 2007 Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats Drug Metab Dispos 35 302 305 10.1124/dmd.106.011718 1:CAS:528:DC%2BD2sXhvVKrsLo%3D (Pubitemid 46148744)
16. U Fuhr A Jetter J Kirchheiner 2007 Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach Clin Pharmacol Ther 81 270 283 10.1038/sj.clpt.6100050 1:CAS:528:DC%2BD2sXisFyrtbc%3D (Pubitemid 46174825)