Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 871, Issue 1, 2008, Pages 78-89

  Zhang, Shaoyu ^a,b   Song, Naining ^a,b   Li, Quansheng ^b   Fan, Huirong ^b   Liu, Changxiao ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Cytochrome P450; In vivo; LC MS MS; Phenotyping; Rat

Indexed keywords

CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; EXTRACTION; FLUIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMAS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; STANDARDS;

CYP2C19; CYTOCHROME P450 (CYP); DEXTROMETHORPHAN (DM); DEXTRORPHAN (DP); INTERNAL STANDARD (IS); LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS MS); MELOXICAM; MIDAZOLAM (MDZ); OFLOXACIN; PARACETAMOL (PA); PHENOTYPING; RAT PLASMAS; SAMPLE PREPARATIONS; SOLID PHASE EXTRACTION (SPE);

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

4 HYDROXYTOLBUTAMIDE; 4' HYDROXYMEPHENYTOIN; ALPHA HYDROXYMIDAZOLAM; AMMONIUM FORMATE; BETA GLUCURONIDASE; BRODIMOPRIM; CARBOXYTOLBUTAMIDE; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DEXTRORPHAN; FORMIC ACID; MELOXICAM; MEPHENYTOIN; METHANOL; MIDAZOLAM; OFLOXACIN; PARACETAMOL; PHENACETIN; TOLBUTAMIDE;

ACCURACY; ARTICLE; CALIBRATION; COMPARATIVE STUDY; CONTROLLED STUDY; FREEZE THAWING; INFORMATION PROCESSING; LIQUID CHROMATOGRAPHY; MALE; MONITORING; NONHUMAN; PHENOTYPE; PLASMA; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; ROOM TEMPERATURE; SAMPLE; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; MALE; MEPHENYTOIN; MIDAZOLAM; PHENACETIN; PHENOTYPE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TOLBUTAMIDE;

RATTUS;

EID: 48049090033     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.06.034     Document Type: Article

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