A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 5, 2004, Pages 1203-1212

  Jerdi, Mallorie Clement ^a   Daali, Youssef ^a   Oestreicher, Mitsuko Kondo ^a   Cherkaoui, Samir ^b   Dayer, Pierre ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b Bracco Suisse SA   (Switzerland)

Author keywords

Cocktail; Cytochrome P450; HPLC; Validation

Indexed keywords

1 HYDROXYMIDAZOLAM; 4 HYDROXYFLURBIPROFEN; 5 HYDROXYOMEPRAZOLE; ACETONITRILE; AMMONIUM ACETATE; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; FLURBIPROFEN; METHANOL; MIDAZOLAM; OMEPRAZOLE; PARAXANTHINE; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD SAMPLING; CHROMATOGRAPHY; DRUG METABOLISM; DRUG TRANSFORMATION; FLOW RATE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; PARTICLE SIZE; PHENOTYPE; PLASMA; PRIORITY JOURNAL; STRUCTURE ANALYSIS; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

BIOTRANSFORMATION; CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; FLURBIPROFEN; HUMANS; ISOENZYMES; MIDAZOLAM; OMEPRAZOLE; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 4344576481     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.03.021     Document Type: Article

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