메뉴 건너뛰기




Volumn 8, Issue 4, 2012, Pages 614-623

UPLC-MS based metabolomics study on Senecio scandens and S. vulgaris: An approach for the differentiation of two Senecio herbs with similar morphology but different toxicity

Author keywords

Hepatotoxic pyrrolizidine alkaloids; Metabolomics; Morphological similarity; Senecio; Toxic difference

Indexed keywords

ADONIFOLINE; BIOLOGICAL MARKER; HERBACEOUS AGENT; INTEGERRIMINE N OXIDE; OTHONNINE; PLATYPHYLLINE; PYRROLIZIDINE ALKALOID; RETRORSINE; RETRORSINE N OXIDE; SENECIONINE; SENECIONINE N OXIDE; SENECIPHYLLINE; UNCLASSIFIED DRUG;

EID: 84864073662     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0354-8     Document Type: Article
Times cited : (33)

References (41)
  • 1
    • 33846515112 scopus 로고    scopus 로고
    • Partial least squares: A versatile tool for the analysis of high dimensional genomic data
    • doi:10.1093/bib/bb1016
    • Boulesteix, A. L., & Strimmer, K. (2006). Partial least squares: A versatile tool for the analysis of high dimensional genomic data. Briefings in Bioinformatics, 8, 32-44. doi: 10. 1093/bib/bb1016.
    • (2006) Briefings in Bioinformatics , vol.8 , pp. 32-44
    • Boulesteix, A.L.1    Strimmer, K.2
  • 2
    • 77951555132 scopus 로고    scopus 로고
    • Genotoxicity of pyrrolizidine alkaloids
    • doi:10.1002/jat.1504
    • Chen, T., Mei, N., & Fu, P. P. (2010). Genotoxicity of pyrrolizidine alkaloids. Journal of Applied Toxicology, 30, 183-196. doi: 10. 1002/jat. 1504.
    • (2010) Journal of Applied Toxicology , vol.30 , pp. 183-196
    • Chen, T.1    Mei, N.2    Fu, P.P.3
  • 4
    • 77949803652 scopus 로고    scopus 로고
    • Combined NMR and LC-DAD-MS reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Mitiorrhiza Bunge
    • doi:10.1021/pr901045c
    • Dai, H., Xia, C. N., Liu, H. B., Hao, F. H., & Tang, H. R. (2010). Combined NMR and LC-DAD-MS reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Mitiorrhiza Bunge. Journal of Proteome Research, 9, 1565-1578. doi: 10. 1021/pr901045c.
    • (2010) Journal of Proteome Research , vol.9 , pp. 1565-1578
    • Dai, H.1    Xia, C.N.2    Liu, H.B.3    Hao, F.H.4    Tang, H.R.5
  • 5
    • 34248512719 scopus 로고    scopus 로고
    • Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry
    • doi:10.1038/nprot.2007.95
    • De Vos, R. C. H., Moco, S., Lommen, A., Keurentjes, J. J. B., Bino, R. J., & Hall, R. D. (2007). Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry. Nature Protocols, 2, 778-791. doi: 10. 1038/nprot. 2007. 95.
    • (2007) Nature Protocols , vol.2 , pp. 778-791
    • de Vos, R.C.H.1    Moco, S.2    Lommen, A.3    Keurentjes, J.J.B.4    Bino, R.J.5    Hall, R.D.6
  • 7
    • 0035206839 scopus 로고    scopus 로고
    • Genotoxic pyrrolizidine alkaloids and pyrrolizidine alkaloids-mechanisms leading to DNA adduct formation and tumorigenicity
    • doi:10.1081/GNC-100107580
    • Fu, P. P., Chou, M. W., Xia, Q. S., Yang, Y. C., Yan, J., Deorge, D. R., et al. (2001). Genotoxic pyrrolizidine alkaloids and pyrrolizidine alkaloids-mechanisms leading to DNA adduct formation and tumorigenicity. Journal of Environmental Science and Health, Part C, 19, 353-386. doi: 10. 1081/GNC-100107580.
    • (2001) Journal of Environmental Science and Health, Part C , vol.19 , pp. 353-386
    • Fu, P.P.1    Chou, M.W.2    Xia, Q.S.3    Yang, Y.C.4    Yan, J.5    Deorge, D.R.6
  • 8
    • 67649385775 scopus 로고    scopus 로고
    • Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry
    • doi:10.1016/j.chroma.2009.05.069
    • Glauser, G., Guillarme, D., Glauer, G., Boccard, J., Rudaz, S., Wolfender, J. L., et al. (2009). Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry. Phytochemical Analysis, 30, 5660-5668. doi: 10. 1016/j. chroma. 2009. 05. 069.
    • (2009) Phytochemical Analysis , vol.30 , pp. 5660-5668
    • Glauser, G.1    Guillarme, D.2    Glauer, G.3    Boccard, J.4    Rudaz, S.5    Wolfender, J.L.6
  • 9
    • 33947618503 scopus 로고    scopus 로고
    • A single HPLC-PDA-APCI/MS method for the quantititative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium
    • doi:10.1002/pca.970
    • Harris, C. S., Burt, A. J., Saleem, A., Le, P. M., Martineau, L. C., Haddad, P. S., et al. (2007). A single HPLC-PDA-APCI/MS method for the quantititative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium. Phytochemical Analysis, 18, 161-169. doi: 10. 1002/pca. 970.
    • (2007) Phytochemical Analysis , vol.18 , pp. 161-169
    • Harris, C.S.1    Burt, A.J.2    Saleem, A.3    Le, P.M.4    Martineau, L.C.5    Haddad, P.S.6
  • 10
    • 0029901470 scopus 로고    scopus 로고
    • Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline
    • doi:10.1007/BF02529131
    • Huxtable, R. J., Yan, C. C., Wild, S., Maxwell, S., & Cooper, R. (1996). Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline. Neurochemical Research, 21, 141-146. doi: 10. 1007/BF02529131.
    • (1996) Neurochemical Research , vol.21 , pp. 141-146
    • Huxtable, R.J.1    Yan, C.C.2    Wild, S.3    Maxwell, S.4    Cooper, R.5
  • 11
    • 13244264923 scopus 로고    scopus 로고
    • Metabolite fingerprinting and profiling in plants using NMR
    • doi:10.1093/jxb/eri010
    • Krishnan, P., Kruger, N. J., & Ratcliffe, R. G. (2005). Metabolite fingerprinting and profiling in plants using NMR. Journal of Experimental Botany, 56, 255-265. doi: 10. 1093/jxb/eri010.
    • (2005) Journal of Experimental Botany , vol.56 , pp. 255-265
    • Krishnan, P.1    Kruger, N.J.2    Ratcliffe, R.G.3
  • 12
    • 0034666010 scopus 로고    scopus 로고
    • Protein targets of monocrotaline pyrrol in pulmonary artery endothelial cells
    • doi:10.1074/jbc.M001372200
    • Lame, M. W., Jones, A. D., Wilson, D. W., Dunston, S. K., & Segall, H. J. (2000). Protein targets of monocrotaline pyrrol in pulmonary artery endothelial cells. Journal of Biological Chemistry, 275, 29091-29099. doi: 10. 1074/jbc. M001372200.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 29091-29099
    • Lame, M.W.1    Jones, A.D.2    Wilson, D.W.3    Dunston, S.K.4    Segall, H.J.5
  • 13
    • 39749202897 scopus 로고    scopus 로고
    • Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang)
    • doi:10.1002/rcm.3398
    • Li, S. L., Lin, G., Fu, P. P., Chan, C. L., Li, M., Jiang, Z. H., et al. (2008). Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang). Rapid Communications in Mass Spectrometry, 22, 591-602. doi: 10. 1002/rcm. 3398.
    • (2008) Rapid Communications in Mass Spectrometry , vol.22 , pp. 591-602
    • Li, S.L.1    Lin, G.2    Fu, P.P.3    Chan, C.L.4    Li, M.5    Jiang, Z.H.6
  • 14
    • 0031449069 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloids
    • doi:10.1039/NP9971400653
    • Liddell, J. R. (1997). Pyrrolizidine alkaloids. Natural Products Reports, 14, 653-660. doi: 10. 1039/NP9971400653.
    • (1997) Natural Products Reports , vol.14 , pp. 653-660
    • Liddell, J.R.1
  • 15
    • 0031764999 scopus 로고    scopus 로고
    • Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid
    • doi:10.1002/(SICI)1097-0231
    • Lin, G., Zhou, K. Y., Zhao, X. G., Wang, Z. T., & But, P. P. (1998). Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid. Rapid Communication in Mass Spectrometry, 12, 1445-1456. doi: 10. 1002/(SICI)1097-0231.
    • (1998) Rapid Communication in Mass Spectrometry , vol.12 , pp. 1445-1456
    • Lin, G.1    Zhou, K.Y.2    Zhao, X.G.3    Wang, Z.T.4    But, P.P.5
  • 17
    • 34248580879 scopus 로고    scopus 로고
    • Gas chromatography mass spectrometry-based metabolite profiling in plants
    • doi:10.1038/nprot.2006.59
    • Lise, J., Schauer, N., Kopka, J., Willmitzer, L., & Fernie, A. R. (2006). Gas chromatography mass spectrometry-based metabolite profiling in plants. Nature Protocols, 1, 387-396. doi: 10. 1038/nprot. 2006. 59.
    • (2006) Nature Protocols , vol.1 , pp. 387-396
    • Lise, J.1    Schauer, N.2    Kopka, J.3    Willmitzer, L.4    Fernie, A.R.5
  • 18
    • 34250750330 scopus 로고    scopus 로고
    • Extraction and ultra-performance liquid chromatography of hydrophilic and lipophilic bioactive components in a Chinese herb Radix Salviae Miltiorrhizae
    • doi:10.1016/j.chroma.2007.05.018
    • Liu, M., Li, Y. G., Chou, G. X., Cheng, X. M., Zhang, M., & Wang, Z. T. (2007). Extraction and ultra-performance liquid chromatography of hydrophilic and lipophilic bioactive components in a Chinese herb Radix Salviae Miltiorrhizae. Journal of Chromatography A, 1157, 51-55. doi: 10. 1016/j. chroma. 2007. 05. 018.
    • (2007) Journal of Chromatography A , vol.1157 , pp. 51-55
    • Liu, M.1    Li, Y.G.2    Chou, G.X.3    Cheng, X.M.4    Zhang, M.5    Wang, Z.T.6
  • 19
    • 33751301991 scopus 로고    scopus 로고
    • Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: Comparison of different analytical approaches during analysis of diclofenac gel
    • doi:10.1002/jssc.200600147
    • Novakova, L., Solichova, D., & Solich, P. (2006). Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: Comparison of different analytical approaches during analysis of diclofenac gel. Journal of Separation Science, 29, 2433-2443. doi: 10. 1002/jssc. 200600147.
    • (2006) Journal of Separation Science , vol.29 , pp. 2433-2443
    • Novakova, L.1    Solichova, D.2    Solich, P.3
  • 20
    • 0030750492 scopus 로고    scopus 로고
    • From gene to screen with yeast
    • doi:10.1016/S0959-437X(97)80156-6
    • Oliver, S. G. (1997). From gene to screen with yeast. Current Opinion in Genetics and Development, 7, 405-409. doi: 10. 1016/S0959-437X(97)80156-6.
    • (1997) Current Opinion in Genetics and Development , vol.7 , pp. 405-409
    • Oliver, S.G.1
  • 23
    • 0028798219 scopus 로고
    • Medicinal plants in Europe containing pyrrolizidine alkaloids
    • Roeder, E. (1995). Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie, 50, 83-98.
    • (1995) Pharmazie , vol.50 , pp. 83-98
    • Roeder, E.1
  • 24
    • 0032743167 scopus 로고    scopus 로고
    • Analysis of pyrrolizidine alkaloids
    • Roeder, E. (1999). Analysis of pyrrolizidine alkaloids. Current Organic Chemistry, 3(6), 557-576.
    • (1999) Current Organic Chemistry , vol.3 , Issue.6 , pp. 557-576
    • Roeder, E.1
  • 25
    • 0033788020 scopus 로고    scopus 로고
    • Medicinal plants in China containing pyrrolizidine alkaloids
    • Roeder, E. (2000). Medicinal plants in China containing pyrrolizidine alkaloids. Pharmazie, 55, 711-726.
    • (2000) Pharmazie , vol.55 , pp. 711-726
    • Roeder, E.1
  • 26
    • 0019457601 scopus 로고
    • Plant sources of hepatotoxic pyrrolizidine alkaloids
    • doi:10.1021/np50014a001
    • Smith, L. W., & Culvenor, C. C. J. (1981). Plant sources of hepatotoxic pyrrolizidine alkaloids. Journal of Natural Products, 44, 129-152. doi: 10. 1021/np50014a001.
    • (1981) Journal of Natural Products , vol.44 , pp. 129-152
    • Smith, L.W.1    Culvenor, C.C.J.2
  • 27
    • 0032140459 scopus 로고    scopus 로고
    • Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells
    • doi:10.1006/taap.1998.8458
    • Thomas, H. C., Lame, M. W., Dunston, S. K., Segall, H. J., & Wilson, D. W. (1997). Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells. Toxicology and Applied Pharmacology, 151, 236-244. doi: 10. 1006/taap. 1998. 8458.
    • (1997) Toxicology and Applied Pharmacology , vol.151 , pp. 236-244
    • Thomas, H.C.1    Lame, M.W.2    Dunston, S.K.3    Segall, H.J.4    Wilson, D.W.5
  • 28
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • doi:10.1002/cem.695
    • Trygg, J., & Wold, S. (2002). Orthogonal projections to latent structures (O-PLS). Journal of Chemometrics, 16, 119-128. doi: 10. 1002/cem. 695.
    • (2002) Journal of Chemometrics , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 29
    • 84864031072 scopus 로고    scopus 로고
    • Umetrics, Kinnelon: Umetrics AB
    • Umetrics. (2008). User guide of SIMCA-P+ (p. 346). Kinnelon: Umetrics AB.
    • (2008) User Guide of SIMCA-P+ , pp. 346
  • 30
    • 33747019547 scopus 로고    scopus 로고
    • Centering, scaling, and transformations: improving the biological information content of metabolomics data
    • van den Berg, R. A., Hoefsloot, H. C., Westerhuis, J. A., Smilde, A. K., & van der Werf, M. J. (2006). Centering, scaling, and transformations: improving the biological information content of metabolomics data. BMC Genomics, 7, 142-156.
    • (2006) BMC Genomics , vol.7 , pp. 142-156
    • van den Berg, R.A.1    Hoefsloot, H.C.2    Westerhuis, J.A.3    Smilde, A.K.4    van der Werf, M.J.5
  • 31
    • 0033915509 scopus 로고    scopus 로고
    • Veno-occlusive liver disease induced by Senecio vulgaris toxicity
    • Vilar, J. H., Garcia, M., & Cabrera, P. (2000). Veno-occlusive liver disease induced by Senecio vulgaris toxicity. Gastroenterology Hepatology, 23, 285-286.
    • (2000) Gastroenterology Hepatology , vol.23 , pp. 285-286
    • Vilar, J.H.1    Garcia, M.2    Cabrera, P.3
  • 32
    • 33144456906 scopus 로고    scopus 로고
    • Metabonomics and biomarker discovery: LCMS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis
    • doi:10.1021/ac051705s
    • Wagner, S., Scholz, K., Donegan, M., Burton, L., Wingate, J., & Volkel, W. (2006). Metabonomics and biomarker discovery: LCMS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Analytical Chemistry, 78, 1296-1305. doi: 10. 1021/ac051705s.
    • (2006) Analytical Chemistry , vol.78 , pp. 1296-1305
    • Wagner, S.1    Scholz, K.2    Donegan, M.3    Burton, L.4    Wingate, J.5    Volkel, W.6
  • 33
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    • doi:10.1021/ac0713510
    • Wiklund, S., Johansson, E., Sjostrom, L., Mellerowicz, E. J., Edlund, U., Trygg, J., et al. (2008). Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Analysis Chemistry, 80, 115-122. doi: 10. 1021/ac0713510.
    • (2008) Analysis Chemistry , vol.80 , pp. 115-122
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4    Edlund, U.5    Trygg, J.6
  • 35
    • 51649123674 scopus 로고    scopus 로고
    • Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs
    • doi:10.1007/s11306-008-0115-5
    • Xie, G. X., Ni, Y., Su, M. M., Zhang, Y. Y., Xiao, P. G., Jia, W., et al. (2008). Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs. Metabolomics, 4, 248-260. doi: 10. 1007/s11306-008-0115-5.
    • (2008) Metabolomics , vol.4 , pp. 248-260
    • Xie, G.X.1    Ni, Y.2    Su, M.M.3    Zhang, Y.Y.4    Xiao, P.G.5    Jia, W.6
  • 36
    • 71949108659 scopus 로고    scopus 로고
    • Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry
    • doi:10.1002/rcm.4329
    • Xiong, A. Z., Yang, L., He, Y. Q., Wang, C. H., Bligh, S. W. A., Wang, Z. T., et al. (2009). Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 23, 3907-3916. doi: 10. 1002/rcm. 4329.
    • (2009) Rapid Communications in Mass Spectrometry , vol.23 , pp. 3907-3916
    • Xiong, A.Z.1    Yang, L.2    He, Y.Q.3    Wang, C.H.4    Bligh, S.W.A.5    Wang, Z.T.6
  • 37
    • 70350748757 scopus 로고    scopus 로고
    • Preliinary phytochemical test of Scandens Buch.-Ham. and examination on chemical composition of antimicrobial part
    • Xu, X. B., Lin, H. Y., Feng, Y. S., & Chen, J. J. (2006). Preliinary phytochemical test of Scandens Buch.-Ham. and examination on chemical composition of antimicrobial part. Journal of Traditional Chinese Veterinary Medicine, 3, 10-13.
    • (2006) Journal of Traditional Chinese Veterinary Medicine , vol.3 , pp. 10-13
    • Xu, X.B.1    Lin, H.Y.2    Feng, Y.S.3    Chen, J.J.4
  • 38
    • 58149087636 scopus 로고    scopus 로고
    • Bile acids metabonomic study on the CCl4- and α-Naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry
    • doi:10.1021/tx800225q
    • Yang, L., Xiong, A. Z., He, Y. Q., Wang, Z. Y., Wang, C. H., Wang, Z. T., et al. (2008). Bile acids metabonomic study on the CCl4- and α-Naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. Chemical Research in Toxicology, 21, 2280-2288. doi: 10. 1021/tx800225q.
    • (2008) Chemical Research in Toxicology , vol.21 , pp. 2280-2288
    • Yang, L.1    Xiong, A.Z.2    He, Y.Q.3    Wang, Z.Y.4    Wang, C.H.5    Wang, Z.T.6
  • 39
    • 79960039689 scopus 로고    scopus 로고
    • Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS
    • doi:10.1016/j.jpba.2011.05.004
    • Yang, X. J., Yang, L., Xiong, A. Z., Li, D. X., & Wang, Z. T. (2011). Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS. Journal of Pharmaceutical and Biomedical Analysis, 56, 165-172. doi: 10. 1016/j. jpba. 2011. 05. 004.
    • (2011) Journal of Pharmaceutical and Biomedical Analysis , vol.56 , pp. 165-172
    • Yang, X.J.1    Yang, L.2    Xiong, A.Z.3    Li, D.X.4    Wang, Z.T.5
  • 40
    • 70349321699 scopus 로고    scopus 로고
    • A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry
    • doi:10.1039/b820224a
    • Yin, P. Y., Wan, D. F., Zhao, C. Z., Chen, J., Xu, G. W., et al. (2009). A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. Molecular Biosystems, 5, 868-876. doi: 10. 1039/b820224a.
    • (2009) Molecular Biosystems , vol.5 , pp. 868-876
    • Yin, P.Y.1    Wan, D.F.2    Zhao, C.Z.3    Chen, J.4    Xu, G.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.