Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs

Metabolomics

Volumn 4, Issue 3, 2008, Pages 248-260

  Xie, Guo X ^a   Ni, Yan ^b   Su, Ming M ^b   Zhang, Yuan Y ^b   Zhao, Ai H ^b   Gao, Xian F ^b   Liu, Zhong ^b   Xiao, Pei G ^c   Jia, Wei ^a,b  

^a Shanghai Jiao Tong University   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Metabolite profiling; Multivariate statistical analysis; Panax; Saponin; UPLC QTOFMS

Indexed keywords

IVA; PANAX; PANAX GINSENG; PANAX JAPONICUS; PANAX NOTOGINSENG;

EID: 51649123674     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-008-0115-5     Document Type: Article

References (37)

1. Akerele, O. (1992). WHO guidelines for the assessment of herbal medicines. Fitoterapia, 63, 99-104.
2. Anterola, A. M., & Lewis, N. G. (2002). Trends in lignin modification: A comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity. Phytochemistry, 61, 221-294. doi: 10.1016/S0031-9422(02)00211-X.
3. Brekhman, I., & Dardymov, I. (1969). New substances of plant origin which increase nonspecific resistance. Annual Review of Pharmacology, 9, 419-430. doi: 10.1146/annurev.pa.09.040169.002223.
4. Chan, E. C. Y., Yap, S. L., Lau, A. J., Leow, P. C., Toh, D. F., & Koh, H. L. (2007). Ultra-performance liquid chromatography/ time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Communications in Mass Spectrometry, 21, 519-528. doi: 10.1002/rcm.2864.
5. Chang, W. T., Thissen, U., Ehlert, K. A., Koek, M. M., Jellema, R. H., Hankemeier, T., et al. (2006). Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy. Planta Medica, 72, 458-467. doi: 10.1055/s-2005-916241.
6. Cloarec, O., Dumas, M. E., Trygg, J., Craig, A., Barton, R. H., Lindon, J. C., et al. (2005). Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies. Analytical Chemistry, 77, 517-526. doi: 10.1021/ ac048803i.
7. Eisenreich, W., & Bacher, A. (2007). Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry. Phytochemistry, 68, 2799-2815. doi: 10.1016/ j.phytochem.2007.09.028.
8. Farag, M. A., Huhman, D. V., Lei, Z., & Sumner, L. W. (2007). Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Phytochemistry, 68, 342-354. doi: 10.1016/j.phytochem.2006.10.023.
9. Fiehn, O. (2002). Metabolomics-the link between genotypes and phenotypes. Plant Molecular Biology, 48, 155-171. doi: 10.1023/ A:1013713905833.
10. Fiehn, O., & Weckwerth, W. (2003). Deciphering metabolic networks. European Journal of Biochemistry, 270, 579-588. doi: 10.1046/ j.1432-1033.2003.03427.x.
11. Fiehn, O., Kopka, J., Dörmann, P., Altmann, T., Trethewey, R. N., & Willmitzer, L. (2000). Metabolic profiling for plant functional genomics. Nature Biotechnology, 18, 1157-1161. doi: 10.1038/81137.
12. Fukusaki, E., Jumtee, K., Bamba, T., Yamaji, T., & Kobayashi, A. (2006). Metabolic fingerprinting and profiling of Arabidopsis thaliana leaf and its cultured cells T87 by GC/MS. Zeitschrift Fur Naturforschung, 61, 267-272.
13. Gao, X. D. M., Zhao, A., Xie, G., & Jia, W. (2008). Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography. Biomedical Chromatography, 22, 244-249. doi: 10.1002/bmc.915.
14. Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G., & Kell, D. B. (2004). Metabolomics by numbers: Acquiring and understanding global metabolite data. Trends in Biotechnology, 22, 245-252. doi: 10.1016/j.tibtech.2004.03.007.
15. Guan, J., Lai, C. M., & Li, S. P. (2007). A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 44, 996-1000. doi: 10.1016/j.jpba.2007.03.032.
16. Guo, Q., Yu, X. L., & Hu, X. X. (2004). Progress of chemical and pharmacological research of Panax japonicus. Research & Information on Traditional Chinese Medicine, 6, 17-19.
17. Hall, R. D. (2006). Plant metabolomics: From holistic hope, to hype, to hot topic. The New Phytologist, 169, 453-468. doi: 10.1111/ j.1469-8137.2005.01632.x.
18. Holmes, E., Tang, H. R., Wang, Y. L., & Seger, C. (2006). The assessment of plant metabolite profiles by NMR-based methodologies. Planta Medica, 72, 771-785. doi: 10.1055/s-2006-946682.
19. Huhman, D. V., & Sumner, L. W. (2002). Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Phytochemistry, 59, 347-360. doi: 10.1016/S0031-9422(01)00432-0.
20. Jiangsu New Medical College. (1985). Dictionary of Chinese Materia Medica. Shanghai Science and Technology Press, Shanghai, pp. 417-420.
21. Kevin, P. B., Jose, C. P., Mark, W., John, P. S., Kate, Y., Renata, O., et al. (2007). MS E with mass defect filtering for in vitro and in vivo metabolite identification. Rapid Communications in Mass Spectrometry, 21, 1485-1496. doi: 10.1002/rcm.2996.
22. Long, M., Millar, D. J., Kimura, Y., Donovan, G., Rees, J., Fraser, P. D., et al. (2006). Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: Identification of a high antioxidant fruit line. Phytochemistry, 67, 1750-1757. doi: 10.1016/ j.phytochem.2006.02.022.
23. Mahady, G. B., Fong, H. H. S., & Farnsworth, N. R. (2001). Botanical Dietary Supplements: Quality, Safety, and Efficacy. Lisse, The Netherlands: Swets & Zeitlinger Publishers, B.V.
24. National Committee of Pharmacopoeia. (2005). Pharmacopoeia of the People's Republic of China (Vol. I, pp. 10). Beijing: Chemical Industry Press.
25. Nordstrom, A., O'Maille, G., Qin, C., & Siuzdak, G. (2006). Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Analytical Chemistry, 78, 3289-3295. doi: 10.1021/ac060245f.
26. Oliver, S. G., Winson, M. K., Kell, D. B., & Baganz, F. (1998). Systematic functional analysis of the yeast genome. Trends in Biotechnology, 16, 373-378. doi: 10.1016/S0167-7799(98)01214-1.
27. Rochfort, S. (2005). Metabolomics reviewed: A new "omics" platform technology for systems biology and implications for natural products research. Journal of Natural Products, 68, 1813-1820. doi: 10.1021/np050255w.
28. Shen, Y. F., Zhang, R., Moore, R. J., Kim, J., Metz, T. O., Hixson, K. K., et al. (2005). Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1,000-1,500 and capabilities in proteomics and metabolomics. Analytical Chemistry, 77, 3090-3100. doi: 10.1021/ac0483062.
29. Tarachiwin, L., Ute, K., Kobayashi, A., & Fukusaki, E. (2007). 1H NMR based metabolic profiling in the evaluation of Japanese green tea quality. Journal of Agricultural and Food Chemistry, 55, 9330-9336. doi: 10.1021/jf071956x.
30. Wagner, S., Scholz, K., Donegan, M., Burton, L., Wingate, J., & Völkel, W. (2006). Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Analytical Chemistry, 78, 1296-1305. doi: 10.1021/ac051705s.
31. Wang, M., Lamers, R. J. A. N., Korthout, H. A. A. J., Van Nesselrooij, J. H. J., Witkamp, R. F., Van Der Heijden, R., et al. (2005). Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology. Phytotherapy Research, 19, 173-182. doi: 10.1002/ptr.1624.
32. Want, E. J., Cravatt, B. F., & Siuzdak, G. (2005). The expanding role of mass spectrometry in metabolite profiling and characterization. ChemBioChem, 6, 1941-1951. doi: 10.1002/cbic.200500151.
33. Wei, J. X., Chen, Y. G., & Du, Y. C. (1991). Introduction of separation method of dammarane-type saponins in Panax samples. Academic Journal of Kunming Medical College, 12, 56-64.
34. Wilson, I. D., Nicholson, J. K., Castro-Perez, J., Granger, J. H., Johnson, K. A., Smith, B. W., et al. (2005). High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. Journal of Proteome Research, 4, 591-598. doi: 10.1021/pr049769r.
35. Xie, G. X., Plumb, R., Su, M. M., Xu, Z. H., Zhao, A. H., Qiu, M. F., et al. (2008). Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. Journal of Separation Science, 1015-1026. doi:10.1002/jssc.200700650.
36. Zhong, G. G., Sun, C. W., Li, Y. Y., Qi, H., Zhao, C. Y., Jiang, Y., et al. (1995). Calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd. Acta Pharmacologica Sinica, 16, 255-260.
37. Zuo, R., Yuan, D. (2005). Research on chemical constituents and biological activities of Rhizoma of Panax japonicus. Lishizhen Medicine and Materia Medica Research, 16, 838-841.