Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of salvia miltiorrhiza bunge

Journal of Proteome Research

Volumn 9, Issue 3, 2010, Pages 1565-1578

  Dai, Hui ^a,c   Xiao, Chaoni ^a,b,c   Liu, Hongbing ^a,c   Hao, Fuhua ^a   Tang, Huiru ^a  

^a Wuhan National Laboratory for Optoelectronics   (China)

^b NORTHWEST UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Ecotype; LC DAD MS; NMR; OPLS DA (orthogonal projection to latent structure with discriminant analysis); PCA (principal component analysis); Salvia miltiorrhiza bunge (smb)

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; AMINO ACID DERIVATIVE; ASPARTIC ACID; CARBOHYDRATE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHOLINE; FUMARIC ACID; GALACTOSE; GLUCOSE; GLUTAMINE; ISOLEUCINE; LACTIC ACID; LITHOSPERMIC ACID; MALIC ACID; MALONIC ACID; MELIBIOSE; N ACETYLGLUTAMIC ACID; POLYPHENOL DERIVATIVE; PYROGLUTAMIC ACID; RAFFINOSE; ROSMARINIC ACID; SALVIANOLIC ACID B; SHIKIMIC ACID; SUCCINIC ACID; SUCROSE; TARTARIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE; YUNNANEIC ACID D;

AMINO ACID METABOLISM; ANALYTIC METHOD; ARTICLE; BIOMICS; CARBOHYDRATE METABOLISM; CITRIC ACID CYCLE; CULTIVAR; ECOTYPE; GENE FUNCTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; METABONOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHENOTYPE; PLANT GROWTH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SALVIA MILTIORRHIZA;

ANALYSIS OF VARIANCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENOTYPE; PLANT ROOTS; PRINCIPAL COMPONENT ANALYSIS; SALVIA MILTIORRHIZA;

SALVIA MILTIORRHIZA;

EID: 77949803652     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr901045c     Document Type: Article

References (44)

1. Fiehn, O.; Kopka, J.; Dormann, P.; Altmann, T.; Trethewey, R. N.; Willmitzer, L. Metabolite profiling for plant functional genomics. Nat, Biotechnol. 2000, 18, 1157-1161.
2. Bino, R. J.; Hall, R. D.; Fiehn, O. Kopka, J.; Saito, K.; Draper, J.; Nikoiau, B. J.; Mendes, P.; Roessner-Tunali, U.; Beale, M. H.; Trethewey, R. N.; Lange, B. M.; Wurtele, E. S.; Sumner, L. W. Potential of metabolomics as a functional genomics tool. Trends Plant Sci. 2004, 9, 418-425.
3. Fiehn, O. Metabolomics - the link between genotypes and phenotypes. Plant Mol. Biol. 2002, 48, 155-171.
4. Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomlcs': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical, analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29, 11811189.
5. Tang, H. R.; Wang, Y. L. Metabonomlcs: a revolution in progress. P roe Biochem. Biophys. 2006, 33, 401-417.
6. Raamsdonk, L. M.; Teusink, B.; Broadhurst, D.; Zhang, N. S.; Hayes, A.; Walsh, M. C.; Berden, J. A; Brindle, K. M.; Kell, D. B.; Rowland, J. J.; Westerhoff, H. V.; van Dam, K.; Oliver, S. G. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 2001, 19, 45-50.
7. 1H NMR-based metabonomlcs. Nat. Med. 2002, 8, 1439-1444.
8. 1H NMR spectroscopy in conjunction with multivariate data analysis. I; Proteome Res. 2007, 6, 2605-2614.
9. Wang, Y. L; Utzinger, J.; Saric, J.; Li, J. V.; Burckhardt, J. Dimhofer, S.; Nicholson, J. K.; Singer, B. H.; Brun, R.; Holmes, E. Global metabolic responses of mice to Trypanosoma brucei brucei infection. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 6127-6132.
10. Holmes, E.; Loo, R. L; Stamler, J.; Bictash, M.; Yap, I. K. S.; Chan, Q.; Ebbels, T.; De lorio, M.; Brown, I. J.; Veselkov, K. A.; Daviglus, M. L; Kesteloot, H.; Ueshima, H.; Zhao, L. C.; Nicholson, J. K.; Elliott, P. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008, 453, 396-400.
11. Holmes, E.; Loo, R. L; Cloarec, O.; Coen, M.; Tang, H. R.; Maibaum, E.; Bruce, S.; Chan, Q.; Elliott, P.; Stamler, J.; Wilson, I. D.; Lindon, J. C.; Nicholson, J. K. Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical, total correlation (NMR) spectroscopy. Anal. Chem. 2007, 79, 2629-2640.
12. 1H NMR spectroscopy as a result of metabonomic screening of humans. Analyst 2004, 129, 259-264.
13. Clayton, T. A.; Lindon, J. C.; Cloarec, O.; Antti, H.; Charuel, C.; Hanton, G.; Provost, J. P.; Le Net, J. L.; Baker, D.; Walley, R. J.; Everett, J. R.; Nicholson, J. K. Pharmaco-metabonomic phenotyping and. personalized drug treatment. Nature 2006, 440, 1073-1077.
14. Yap, I. K. S.; Clayton, T. A.; Tang, H.; Everett, J. R.; Hanton, G.; Provost, J. P.; Le Net, J. L.; Charuel, C.; Lindon, J. C.; Nicholson, J. K. An integrated metabonomic approach, to describe temporal metabolic deregulation Induced in the rat by the model hepatotoxin allyl formate, J., Proteome Res. 2006, 5, 2675-2684.
15. Bundy, J. G.; Lenz, E. M.; Bailey, N. J.; Gavaghan, C. L.; Svendsen, Cj Spurgeon, D.; Hankard, P. IC.; Osborn, D.; Weeks, J. A; Trauger, S. A.; Speir, P.; Sanders, I.; Lindon, J. C.; Nicholson, J. K.; Tang, H. R. Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): Identification of new endogenous biomarkers. Environ. Toxicol. Chem. 2002, 21, 1966-1972.
16. Ding, L. N.; Hao, F. H.; Shi, Z. M.; Wang, Y. L; Zhang, H. X.; Tang, H. R.; Dai, J. Y. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies. J. poteome Res. 2009, 8, 2882-2891.
17. 1H NMR spectroscopy and. multivariate data analysis. Plant Phvsiol. 2004, 135, 2398-2410.
18. Tikunov, Y.; Lommen, A.; de Vos, C. H. R.; Verhoeven, H. A; Bino, R. J.; Hall, R. D.; Bovy, A. G. A novel, approach, for nontargeted data analysis for metabolomics. Large-scale profiling of tomato fruit volatiles. Plant Phvsiol. 2005, 139, 1125-1137.
19. Roessner, U.; Luedemann, A.; Brust, D.; Fiehn, O.; Linke, T.; Willmitzer, L.; Fernie, A. R. Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell 2001, 13, 11-29.
20. Weckwerth, W.; Loureiro, M. E.; Wenzel, K.; Fiehn, O. Differential metabolic networks unravel the effects of silent plant phenotypes. Proc. Natl. Acad. Sci. U.S.A. 2004, 101,7809-7814.
21. 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistrv 2003, 62, 949-957.
22. Wang, Y. L.; Tang, H. R.; Nicholson, J. K.; Hylands, P. J.; Sampson, J.; Whitcombe, I.; Stewart, C G.; Calger, S.; Oru, I.; Holmes, E. Metabolomic strategy for the classification and quality control, of phytomedicine: A case study of chamomile flower (Matricaria recutita L). Planta Med. 2004, 70, 250-255.
23. 1H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.). J. Aerie. Food Chem. 2004, 52, 692-700.
24. 1H NMR, GC-EI-TOFMS, and. data set correlation for fruit metabolomics: application to spatial metabolite analysis In melon. Anal. Chem. 2009, 81, 2884-2894,
25. Bottcher, C.; von. Roepenack-Lahaye, E.; Willscher, E.; Scheel, D.; Clemens, S. Evaluation of matrix, effects in metabolite profiling based on capillary liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry. Anal. Chem. 2007, 79, 1507-1513.
26. Xiao, C N.; Dai, H.; Liu, H. B.; Wang, Y. L.; Tang, H. R. Revealing the metabonomic variation of rosemary extracts using 1H NMR spectroscopy and multivariate data analysis, J. Agric. Food Chem. 2008, 56, 10142-10153.
27. Dai, H.; Xiao, C. N.; Liu, H. B.; Tang, H. R. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia Miltiorrhiza Bunge Induced by water depletion. J. Proteome Res. 2010; DOI: pr900995m.
28. Onltsuka, M.; Fujiu, M.; Shinma, N.; Maruyama, H. B. New platelet aggregation inhibitors from Tan-Shen; radix of Salvia Miltiorrhiza Bunge. Chem. Pharm. Bull. 1983, 31, 1670-1675.
29. BaIlHe, A. C.; Thomson, R. H. Naturally occurring quinones. Part XI tanshinones. J. Chem. Soc. C 1968, 48-52.
30. Sugiyama, A.; Zhu, B. M.; Takahara, A.; Satoh, Y.; Hashimoto, K. Cardiac effects of Salvia miltiorrhiza/Dalbergia odorifera mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China. Circ. J. 2002, 66, 182-184.
31. Wasser, S.; Ho, J. M. S.; Ang, H. K.; Tan, C E. L. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. T. Hepatol, 1998, 29, 760-771.
32. Zhang, K. Q.; Bao, Y. D.; Wu, P.; Rosen, R. T.; Ho, C. T. Antioxidative components of Tanshen (Salida Miltiorrhiza Bunge). J. Agric. Food Chem. 1990, 38, 1194-1197.
33. Chen, C.; Tang, H. R.; Sutcliffe, L. H.; Belton, P. S. Green tea polyphenols react with l,l-diphenyl-2-picrylhydrazyl free radicals in the bilayer of liposomes: direct evidence from, electron spin resonance studies. T. Agric. Food Chem. 2000, 48, 5710-5714.
34. Zhang, X. G.; Wang, Y. M.; Luo, G. A.; Cheng, F. X. Studies on resource characteristics of Salvia miltiorrhiza varieties. Chin. Tradit. Herb. Drugs 2002, 33, 742-747.
35. Djoukeng, J. D.; Arbona, V.; Argamasilla, R.; Gomez-Cadenas, A. Flavonoid profiling in leaves of Citrus genotypes under different environmental situations, I, Agric. Food. Chem. 2008, 56, 1108711097.
36. Zhang, H. R.; Li, Z. M.; Gao, Z. M.; Cao, J. B. Analysis of tanshinone IIA and salvianolic acid B content from different Salvia Miltiorrhiza Bunge cultivars. Lishizhen Med. Mater. Med. Res. 2009, 20, 11731174.
37. Ma, H. L; QIn, M. J.; Qi, L. W.; Wu, G.; Shu, P. Improved quality evaluation of Radix Salida miltiorrhiza through simultaneous quantification of seven major active components by highperformance liquid chromatography and principal component analysis. Biomed. Chromatogr. 2007, 21, 931-939.
38. Trygg, J.; Wold, S. Orthogonal projections to latent structures COPLS. J. Chemometr. 2002, 119-128.
39. Fan, W. M. T. Metabolite profiling by one and two dimensional NMR analysis of complex mixtures. Prog. Nucl. Magn. Nucl. Magn. Reson. Spectrosc. 1996, 28, 161-219.
40. Sobolev, A P.; Brosio, E.; Gianferri, R.; Segre, A L. Metabolic profile of lettuce leaves by high-field NMR spectra. Magn. Reson. Chem. 2005, 43, 625-638.
41. Lin, Y. L.; Wang, C. N.; Shiao, Y. J.; Liu, T. Y.; Wang, W. Y. Benzolignanoid and polyphenols from Origanum vulgare. J. Chin. Chem Soc. 2003, 50, 1079-1083.
42. n J. Chromatoer. B 2007, 846, 32-111
43. Tanaka, T.; Nishimura, A.; Kouno, I; Nonaka, G.; Young, T. J. Isolation and characterization of yunnaneic acids A-D, four novel caffeic acid metabolites from Salvia yunnanensis. I. Nat. Prod. 1996, 59, 843-849.
44. 1H NMR spectroscopy. J. Agric. Food Chem. 2001, 49, 2687-2696.