The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry

Journal of Immunological Methods

Volumn 347, Issue 1-2, 2009, Pages 3-11

  Hoofnagle, Andrew N ^a   Wener, Mark H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Autoantibody interference; Heterophile anti reagent antibodies; Hook effect; Immunoassays; Standardization; Tandem mass spectrometry

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; THYROGLOBULIN; THYROGLOBULIN ANTIBODY;

ANTIBODY RESPONSE; BLOOD ANALYSIS; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; FALSE POSITIVE RESULT; FRACTIONATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOASSAY; ISOTOPE DILUTION ASSAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; REVIEW; STANDARDIZATION; TANDEM MASS SPECTROMETRY; THYROGLOBULIN BLOOD LEVEL; THYROID CARCINOMA;

ANTIBODIES, HETEROPHILE; ARTIFACTS; AUTOANTIBODIES; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; IMMUNOASSAY; MEDICAL ERRORS; PREDICTIVE VALUE OF TESTS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; THYROGLOBULIN;

EID: 67650432879     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2009.06.003     Document Type: Review

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