A mechanism-based kinetic analysis of succinimide-mediated deamidation, racemization, and covalent adduct formation in a model peptide in amorphous lyophiles

Journal of Pharmaceutical Sciences

Volumn 101, Issue 9, 2012, Pages 3096-3109

  Dehart, Michael P ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

Amorphous solids; Chemical stability; Deamidation; Lyophilization; Nonreducible aggregates; Peptide stability; Protein aggregation; Solid state stability; Solid state kinetics

Indexed keywords

AMINO ACID DERIVATIVE; ASPARAGINE; CARBONYL DERIVATIVE; GLYCINE; GLYCYLPHENYLALANYLASPARAGYLGLYCINE; GLYCYLVALINE; HYDROXYPROPYLCELLULOSE; METHYLCELLULOSE; PEPTIDE; PHENYLALANINE; SUCCINIMIDE; UNCLASSIFIED DRUG; VALINE; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; COVALENT ADDUCT FORMATION; DEAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; HYDROLYSIS; NUCLEOPHILICITY; PH; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; RACEMIZATION;

EID: 84864067477     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23061     Document Type: Article

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