Kinetics and mechanism for the reaction of cysteine with hydrogen peroxide in amorphous polyvinylpyrrolidone lyophiles

Pharmaceutical Research

Volumn 23, Issue 10, 2006, Pages 2239-2253

  Luo, Dayong ^a   Anderson, Bradley D ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Amorphous solids; Chemical kinetics; Cysteine; Drug stability; Hydrogen peroxide; Lyophilization; Nucleophilic substitution; Poly(vinylpyrrolidone); Solid state kinetics; Thiol oxidation

Indexed keywords

CYSTEINE; HYDROGEN PEROXIDE; POVIDONE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION; DATA ANALYSIS; DYNAMICS; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; PH; PRIORITY JOURNAL; REACTION ANALYSIS; SOLID STATE;

ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; CYSTEINE; DATA INTERPRETATION, STATISTICAL; FREEZE DRYING; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; KINETICS; PHARMACEUTIC AIDS; PHARMACEUTICAL SOLUTIONS; POVIDONE; WATER; X-RAY DIFFRACTION;

EID: 33749473682     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9052-z     Document Type: Article

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