An optimized gene set for transcriptomics based neurodevelopmental toxicity prediction in the neural embryonic stem cell test

Toxicology

Volumn 300, Issue 3, 2012, Pages 158-167

  Pennings, Jeroen L A ^a   Theunissen, Peter T ^a,b   Piersma, Aldert H ^a,c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Embryonic stem cells; Neural development; Principal Component Analysis; Toxicogenomics

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA3; ACETALDEHYDE; ALDEHYDE DEHYDROGENASE FAMILY 1 SUBFAMILY A7; BASONUCLIN; CARBAMAZEPINE; CULLIN 4B; DUAL SPECIFICITY PHOSPHATASE 6; ETS VARIANT GENE 5 PROTEIN; FLUSILAZOLE; HEXACONAZOLE; INTERNEXIN NEURONAL INTERMEDIATE FILAMENT PROTEIN ALPHA; LIPOCORTIN 5; LYMPHOID ENHANCER FACTOR 1; MESODERM SPECIFIC TRANSCRIPT; METHYLMERCURIC CHLORIDE; NEUROPILIN 4; PENICILLIN G; PHENYTOIN; PROTEIN; SEMAPHORIN; SEMAPHORIN 3E; SOMATOMEDIN BINDING PROTEIN 4; STEM CELL FACTOR; TRANSCRIPTION FACTOR FOXC1; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA2; TRYPTOPHAN HYDROXYLASE 1; UNCLASSIFIED DRUG; VALPROIC ACID; WNT1 PROTEIN; WNT5A PROTEIN;

ACCURACY; ANIMAL CELL; ARTICLE; EMBRYONIC STEM CELL; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL EMBRYONIC STEM CELL; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; TRANSCRIPTOMICS;

ALGORITHMS; ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; DATABASES, GENETIC; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; NEURAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; PRINCIPAL COMPONENT ANALYSIS; TOXICITY TESTS;

MURINAE;

EID: 84864039926     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.06.016     Document Type: Article

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