Age-related changes in the function of autophagy in rat kidneys

Age

Volumn 34, Issue 2, 2012, Pages 329-339

  Cui, Jing ^a   Bai, Xue Yuan ^a   Shi, Suozhu ^a   Cui, Shaoyuan ^a   Hong, Quan ^a   Cai, Guangyan ^a   Chen, Xiangmei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Aging; Autophagy; Kidney; Mitochondria; Oxidative damage

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AUTOPHAGY PROTEIN 7; AUTOPHAGY PROTEIN 8; PEPTIDES AND PROTEINS; POLYUBIQUITIN; PROTEASOME; PROTEIN P62; UNCLASSIFIED DRUG;

AGE; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOWN REGULATION; JUVENILE ANIMAL; KIDNEY DISEASE; MALE; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT;

AGING; ANIMALS; AUTOPHAGY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; DEOXYGUANOSINE; DNA DAMAGE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; OXIDATIVE STRESS; RATS; RATS, INBRED F344; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84857914041     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9237-1     Document Type: Article

References (60)

1. Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78:547-581 (Pubitemid 28182903)
2. Bergamini E, Cavallini G, Donati A, Gori Z (2004) The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int J Biochem Cell Biol 36:2392-2404 (Pubitemid 39119754)
3. Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171:603-614 (Pubitemid 41668720)
4. Bjørkøy G, Lamark T, Johansen T (2006) p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy 2:138-139
5. Blagosklonny MV (2008) Aging: ROS or TOR. Cell Cycle 7:3344-3354
6. Brunk UT, Terman A (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 269:1996-2002 (Pubitemid 34437840)
7. Cadenas E, Davies KJ (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29:222-230
8. Cao Y, Klionsky DJ (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 17:839-849 (Pubitemid 47585112)
9. Cheng CH, Chang HR, Chiang CW, Shu KH, Chou MC (2008) Possible mechanism by which rapamycin increases cyclosporine nephrotoxicity. Transplant Proc 40:2373-2375
10. Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6:79-87
11. Dimri GP, Lee X, Basile G, Peacocke M, Campisi J, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367
12. Eskelinen EL (2005) Maturation of autophagic vacuoles in mammalian cells. Autophagy 1:1-10
13. Flores I, Blasco MA (2009) A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS ONE 4:4934-4943
14. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging: 8-hydroxy-2- deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537
15. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C (2001) An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25:386-401 (Pubitemid 34164011)
16. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441:885-889
17. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298-300
18. Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB (2010) Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120:1084-1096
19. He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67-93
20. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
21. Honda Y, Honda S (2002) Oxidative stress and life span determination in the nematode Caenorhabditis elegans. Ann NY Acad Sci 959:466-474 (Pubitemid 34457586)
22. Kadowaki M, Karim MR (2009) Cytosolic LC3 ratio as a quantitative index of macroautophagy. Methods Enzymol 452:199-213
23. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T (2005) Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169:425-434 (Pubitemid 40686693)
24. Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z (2007a) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA 104:14489-14494 (Pubitemid 350010651)
25. Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K (2007b) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131:1149-1163 (Pubitemid 350235021)
26. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al- Regaiey K, Su L, Sharpless NE (2004) Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114:1299-1307 (Pubitemid 40385301)
27. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N (2004) The role of autophagy during the early neonatal starvation period. Nature 432:1032-1036 (Pubitemid 40052234)
28. Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D (2010) Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest 120:1043-1055
29. Levine B, Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477 (Pubitemid 38456176)
30. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Selfeating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741-752 (Pubitemid 47312826)
31. Martinez-Vicente M, Sovak G, Cuervo AM (2005) Protein degradation and aging. Exp Gerontol 40:622-633 (Pubitemid 41265812)
32. McMullen CA, Ferry AL, Gamboa JL, Andrade FH, Dupont- Versteegden EE (2009) Age-related changes of cell death pathways in rat extraocular muscle. Exp Gerontol 44:420-425
33. Miyazawa M, Ishii T, Yasuda K, Noda S, Onouchi H, Hartman PS, Ishii N (2009) The role of mitochondrial superoxide anion (O2-) on physiological aging in C57BL/6J mice. J Radiat Res 50:73-83
34. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075 (Pubitemid 351317450)
35. Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3:542-545 (Pubitemid 350060049)
36. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13:619-624 (Pubitemid 46828485)
37. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282:24131-24145 (Pubitemid 47328003)
38. Rajawat YS, Hilioti Z, Bossis I (2009) Aging: central role for autophagy and the lysosomal degradative system. Ageing Res Rev 8:199-213
39. Rattan SI (2008) Increased molecular damage and heterogeneity as the basis of aging. Biol Chem 389:267-272
40. Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90:313-323 (Pubitemid 351181247)
41. Ravikumar B, Duden R, Rubinsztein DC (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 11:1107-1117 (Pubitemid 34521091)
42. Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 36:585-595 (Pubitemid 38715985)
43. Ravikumar B, Rubinsztein DC (2006) Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med 27:520-527 (Pubitemid 44466658)
44. Richter C, Park JW, Ames BN (1988) Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85:6465-6467
45. Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW (2004) Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 24:8055-8068 (Pubitemid 39167456)
46. Shigenaga MK, Gimeno CJ, Ames BN (1989) Urinary 8- hydroxy-2- deoxyguanosine as a biologic marker of in vivo oxidative DNA damage. Proc Natl Acad Sci USA 86:9697-9701 (Pubitemid 20030700)
47. Sohal RS (2002) Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 33:37-44
48. Sohal RS, Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273:59-63 (Pubitemid 26255420)
49. Sooparb S, Price SR, Shaoguang J, Franch HA (2004) Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus. Kidney Int 65:2135-2144 (Pubitemid 38669999)
50. Suzuki C, Isaka Y, Takabatake Y, Tanaka H, Koike M, Shibata M, Uchiyama Y, Takahara S, Imai E (2008) Participation of autophagy in renal ischemia/reperfusion injury. Biochem Biophys Res Commun 368:100-106
51. Terman A, Brunk UT (2005) The aging myocardium: roles of mitochondrial damage and lysosomal degradation. Heart Lung Circ 14:107-114 (Pubitemid 40895299)
52. Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT (2003) Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp Gerontol 38:863-876 (Pubitemid 36952668)
53. Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci USA 107:9879-9884
54. Ward WF (2002) Protein degradation in the aging organism. Prog Mol Subcell Biol 29:35-42
55. Wohlgemuth SE, Julian D, Akin DE, Fried J, Toscano K, Leeuwenburgh C, Dunn WA Jr (2007) Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res 10:281-292 (Pubitemid 47378708)
56. Wohlgemuth SE, Seo AY, Marzetti E, Lees HA, Leeuwenburgh C (2010) Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol 45:138-148
57. Wu JJ, Quijiao C, Chen E, Liu H, Cao L, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M, Finkel T (2009a) Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging 1:425-437
58. Wu HH, Hsiao TY, Chien CT, Lai MK (2009b) Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat. J Biomed Sci 16:19. doi:10.1186/1423-0127-16-19
59. Xie Z, Klionsky DJ (2007) Autophagosome formation: core machinery and adaptations. Nat Cell Biol 9:1102-1109
60. Yang C, Kaushal V, Shah SV, Kaushal GP (2008) Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294:F777-F787