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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 5031-5034

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives

(6) Hansen, Finn K a,b Khankischpur, Mehdi a Tolaymat, Ibrahim a Mesaros, Renata a Dannhardt, Gerd c Geffken, Detlef a

a UNIVERSITY OF HAMBURG (Germany)

b HEINRICH HEINE UNIVERSITY (Germany)

c JOHANNES GUTENBERG UNIVERSITY (Germany)

Author keywords

5 LOX; Benzothiophene; COX 1 2; Dual inhibitors; Licofelone

Indexed keywords

3 HYDROXYBENZO[B]THIOPHENE 2 CARBOXYLIC ACID DERIVATIVE; 3 HYDROXYBENZOIC ACID; ARACHIDONATE 5 LIPOXYGENASE; BENZOTHIOPHENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CELECOXIB; INDOMETACIN; LICOFELONE; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; NONHUMAN;

ARACHIDONATE 5-LIPOXYGENASE; CARBOXYLIC ACIDS; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; LIPOXYGENASE INHIBITORS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84863985188 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.06.012 Document Type: Article

Times cited : (20)

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