-
3
-
-
0033451654
-
Pharmacology and efficacy of cyclooxygenase (COX) inhibitors
-
(1999)
Am J Med
, vol.107
-
-
Furst, D.1
-
5
-
-
0028230670
-
Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: Prophylactic and therapeutic strategies
-
(1994)
Am J Med
, vol.96
, pp. 274-281
-
-
Hollander, D.1
-
6
-
-
0033452430
-
Profile and mechanisms of gastrointestinal and other side effects of nonstereoidal anti-inflammatory drugs (NSAIDs)
-
(1999)
Am J Med
, vol.107
-
-
Rainsfold, K.D.1
-
8
-
-
0033404030
-
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs)
-
(1999)
Am J Med
, vol.107
-
-
Wallace, J.L.1
-
11
-
-
0034630270
-
Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease
-
(2000)
Arch Int Med
, vol.160
, pp. 913-920
-
-
Lipsky, P.E.1
Brooks, P.2
Crofford, L.J.3
DuBois, R.4
Graham, D.5
Simon, L.S.6
Van de Putte, L.B.A.7
Abramson, S.B.8
-
12
-
-
0028807498
-
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
-
(1995)
Cell
, vol.83
, pp. 473-482
-
-
Morham, S.G.1
-
13
-
-
0028818913
-
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
-
(1995)
Nature
, vol.378
, pp. 406-409
-
-
Dinchuk, J.E.1
-
14
-
-
0028843881
-
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
-
(1995)
Cell
, vol.83
, pp. 483-492
-
-
Langenbach, R.1
-
17
-
-
0031679914
-
Interspecies differences in renal localization of cyclooxygenase isoforms: Implication in nonsteroidal anti-inflammatory drug-related nephrotoxicity
-
(1998)
Toxicol Pathol
, vol.27
, pp. 612-620
-
-
Khan, K.N.1
Venturini, C.M.2
Bunch, R.T.3
Brassard, J.A.4
Koki, A.T.5
Morris, D.L.6
Trump, B.F.7
Maziasz, T.J.8
Alden, C.L.9
-
19
-
-
0031019407
-
Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet
-
(1997)
Hypertension
, vol.29
, Issue.PART 2
, pp. 297-302
-
-
Harding, P.1
Sigmon, D.H.2
Alfie, M.E.3
Huang, P.L.4
Fishman, M.C.5
Beierwalters, W.H.6
Carretero, O.A.7
-
28
-
-
0034604272
-
Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet: A randomized, controlled clinical trial
-
(2000)
Ann Int Med
, vol.133
, pp. 1-9
-
-
Swan, S.K.1
-
29
-
-
0034093534
-
Celecoxib: A review of its use in osteoartritis, rheumatoid arthritis and acute pain
-
(2000)
Drugs
, vol.59
, pp. 975-980
-
-
Clemett, D.1
Goa, K.L.2
-
30
-
-
0034041594
-
Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: Results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip
-
(2000)
Arthritis Rheum
, vol.43
, pp. 978-987
-
-
Cannon, G.W.1
Caldwell, J.R.2
Holt, P.3
McLean, B.4
Seidenberg, B.5
Bolognese, J.6
Ehrich, E.7
Mukhopadhyay, S.8
Daniels, B.9
-
31
-
-
0033582115
-
Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: Randomised double-blind
-
(1999)
Lancet
, vol.354
, pp. 2106-2111
-
-
Emery, P.1
Zeidler, H.2
Kvien, T.K.3
Guslandi, M.4
Naudin, R.5
Stead, H.6
Verburg, K.M.7
Isakson, P.C.8
Hubbard, R.C.9
Geis, G.S.10
-
32
-
-
0020858787
-
Protective effects of prostaglandins against gastric mucosal: Current knowledge and proposed mechanisms
-
(1983)
Am J Physiol
, vol.245
-
-
Miller, T.A.1
-
35
-
-
0034071726
-
Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans
-
(2000)
Gut
, vol.46
, pp. 782-789
-
-
Tatsuguchi, A.1
-
38
-
-
0031052116
-
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
-
(1997)
Gastroenterology
, vol.112
, pp. 387-397
-
-
Mizuno, H.1
Sakamoto, C.2
Matsuda, K.3
Wada, K.4
Uchida, T.5
Noguchi, H.6
Akamatsu, T.7
Kasuga, M.8
-
41
-
-
0033601079
-
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs
-
(1999)
JAMA
, vol.282
, pp. 1929-1933
-
-
Langman, M.J.1
Jensen, D.M.2
Watson, D.J.3
Harper, S.E.4
Zhao, P.L.5
Quan, H.6
Bolognese, J.A.7
Simon, T.J.8
-
42
-
-
0034121667
-
Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double-blind, placebo-controlled trial
-
The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group
-
(2000)
Arthritis Rheum
, vol.43
, pp. 370-377
-
-
Hawkey, C.1
Laine, L.2
Simon, T.3
Beaulieu, A.4
Maldonado-Cocco, J.5
Acevedo, E.6
Shahane, A.7
Quan, H.8
Bolognese, J.9
Mortensen, E.10
-
43
-
-
0033971402
-
Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity?
-
(2000)
Ann Int Med
, vol.132
, pp. 134-143
-
-
Feldman, M.1
McMahon, A.T.2
-
47
-
-
0025022489
-
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
-
(1990)
Nature
, vol.343
, pp. 282-284
-
-
Dixon, R.A.1
Diehl, R.E.2
Opas, E.3
Rands, E.4
Vickers, P.J.5
Evans, J.F.6
Gillard, J.W.7
Miller, D.K.8
-
63
-
-
0032565330
-
Leukotriene modifiers in the treatment of asthma: Look promising across the board of asthma severity
-
(1998)
BMJ
, vol.316
, pp. 1257-1258
-
-
Sampson, A.1
Holgate, S.2
-
66
-
-
0021831728
-
Inflammatory mediators in late antigen-induced rhinitis
-
(1985)
New Engl J Med
, vol.313
, pp. 65-70
-
-
Naclerio, R.M.1
Proud, D.2
Togias, A.G.3
Adkinson N.F., Jr.4
Meyers, D.A.5
Kagey-Sobotka, A.6
Plant, M.7
Norman, P.S.8
Lichtenstein, L.9
-
73
-
-
0025685169
-
Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor
-
(1990)
New Engl J Med
, vol.323
, pp. 1745-1748
-
-
Knapp, H.R.1
-
75
-
-
0026459721
-
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis
-
(1992)
J Rheumatol
, vol.19
, pp. 1537-1541
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Coblyn, J.S.3
Helfgott, S.4
Maier, A.L.5
Petrillo, G.6
Henson, B.7
Rubin, P.8
Sperling, R.9
-
76
-
-
0026542531
-
Phase II study of the safety and efficacy of a 5-lipoxygenase inhibitor in patients with ulcerative colitis
-
(1992)
Am J Gastroenterol
, vol.87
, pp. 342-346
-
-
Collawn, C.1
Rubin, P.2
Perez, N.3
Bobadilla, J.4
Cabrera, G.5
Reyes, E.6
Borovoy, J.7
Kershenobich, D.8
-
78
-
-
0031047277
-
Leukotrienes in ulcerative colitis: Results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591
-
(1997)
Gastroenterology
, vol.112
, pp. 725-732
-
-
Roberts, W.G.1
-
83
-
-
0026746032
-
Antiarthritic profile of BF-389, a novel anti-inflammatory agent with low ulcerogenic liability
-
(1992)
Agents Actions
, vol.37
, pp. 90-98
-
-
Wong, S.1
Lee, S.J.2
Frierson III, M.R.3
Proch, J.4
Miskowski, T.A.5
Rigby, B.S.6
Schmolka, S.J.7
Naismith, R.W.8
Kreutzer, D.C.9
Lindquist, R.10
-
84
-
-
8544266039
-
Evaluation of the anti-inflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RW 63556, in a canine model of inflammation
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1094-1101
-
-
Krichner, T.1
-
85
-
-
0030659394
-
Analysis of a novel anti-inflammatory agent, 1-(7-tert-butyl-2,3-dihydro3,3-dimethylbenzo[b]furan-5-yl)-4-cyclopylbutan- 1-one (PGV-20229), in plasma matrices by stable-isotope-dilution gas chromatography-mass spectrometry
-
(1997)
J Chromatogr B Biomed Sci Appl
, vol.700
, pp. 111-118
-
-
Knight, P.M.1
Scherz, M.W.2
Cruze, C.A.3
Wehmeyer, K.R.4
-
88
-
-
77957174849
-
Subacute and subchronic toxicology studies of CI-986, a novel anti-inflammatory compound
-
(1993)
Fundam Appl Toxicol
, vol.20
, pp. 446-455
-
-
Robertson, D.G.1
Loewen, G.2
Walsh, K.M.3
Dethloff, L.A.4
Sigler, R.S.5
Dominick, M.A.6
Urda, E.R.7
-
89
-
-
0025168984
-
Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism
-
(1990)
Drugs Exp Clin Res
, vol.16
, pp. 137-147
-
-
Hanna, N.1
Marshall, P.J.2
Newton J., Jr.3
Schwartz, L.4
Kirsh, R.5
Dimartino, M.J.6
Adams, J.7
Bender, P.8
Griswold, D.E.9
-
90
-
-
0025306801
-
FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor
-
(1990)
Agents Actions
, vol.30
, pp. 432-442
-
-
Blackham, A.1
Griffiths, R.J.2
Hallam, C.3
Mann, J.4
Mitchell, P.D.5
Norris, A.A.6
Simpson, W.T.7
-
91
-
-
0024314267
-
The in vivo anti-inflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5methyl-1H-pyrazol-3-yl)e thenyl] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase
-
(1989)
Agents Actions
, vol.27
, pp. 391-394
-
-
Schrier, D.J.1
Adamchak, M.A.2
Boctor, A.M.3
Kostlan, C.R.4
Flynn, D.L.5
Jordan J.H., Jr.6
Lesch, M.E.7
Okonkwo, G.C.8
-
92
-
-
0032468953
-
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats
-
(1997)
J Pharm Exp Ther
, vol.287
, pp. 301-306
-
-
Lesch, C.A.1
Gilbertsen, R.B.2
Song, Y.3
Dyer, R.D.4
Schrier, D.5
Kraus, E.6
Sanchez, B.7
Guglietta, A.8
-
93
-
-
0023903001
-
Pharmacology of the dual inhibitor of cyclooxygenase and 5-lipoxygenase 3-hydroxy-5-trifluoromethyl-N-(2-(2-thienyl)-2-phenyl-ethenyl)- benzo(b)thiophene-2-carboxamide
-
(1988)
Arzneimittelforschung
, vol.38
, pp. 372-378
-
-
Rahway, N.J.1
-
95
-
-
0029148708
-
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5- yl]acetic acid in experimental animals
-
(1995)
Arzneimittelforschung
, vol.45
, pp. 159-165
-
-
Algate, D.R.1
Augustin, J.2
Atterson, P.R.3
Beard, D.J.4
Jobling, C.M.5
Laufer, S.6
Munt, P.L.7
-
96
-
-
26844582574
-
Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs
-
(1996)
Fundam Appl Toxicol
, vol.33
, pp. 38-48
-
-
Knight, E.V.1
-
99
-
-
0029088388
-
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]- acetic acid
-
(1995)
Arzneimittelforschung
, vol.45
, pp. 27-32
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
Elsasser, R.4
Albrecht, W.5
Guserle, R.6
Algate, D.R.7
Atterson, P.R.8
Munt, P.L.9
-
100
-
-
0028675272
-
Gastrointestinal tolerance of [2,2-dimethyl6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H-pyrroliz ine-5-yl]acetic acid in the rat
-
(1994)
Arzneimittelforschung
, vol.44
, pp. 1329-1333
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
Elsasser, R.4
Algate, D.R.5
Atterson, P.R.6
Munt, P.L.7
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