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Volumn 43, Issue SUPPL. 1, 2004, Pages

Licofelone - Clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis

Author keywords

5 LOX; Celecoxib; COX 2; COX1; Licofelone; LOX COX inhibitor; NSAIDs; Safety

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LEUKOTRIENE; LICOFELONE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR;

EID: 1242342177     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (100)

References (30)
  • 1
    • 0031680203 scopus 로고    scopus 로고
    • Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
    • Simon LS, Lanza FL, Lipsky PE et al. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum 1998;41:1591-602.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1591-1602
    • Simon, L.S.1    Lanza, F.L.2    Lipsky, P.E.3
  • 2
    • 0035722949 scopus 로고    scopus 로고
    • Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors
    • Komers R, Anderson S, Epstein M. Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors. Am J Kidney Dis 2001;38:1145-57.
    • (2001) Am. J. Kidney Dis. , vol.38 , pp. 1145-1157
    • Komers, R.1    Anderson, S.2    Epstein, M.3
  • 3
    • 0036809604 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors: Promise or peril?
    • Mengle-Gaw LJ, Schwartz BD. Cyclooxygenase-2 inhibitors: promise or peril? Mediators Inflamm 2002;11:275-86.
    • (2002) Mediators Inflamm. , vol.11 , pp. 275-286
    • Mengle-Gaw, L.J.1    Schwartz, B.D.2
  • 4
    • 0033577982 scopus 로고    scopus 로고
    • Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
    • Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999;340: 1888-99.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1888-1899
    • Wolfe, M.M.1    Lichtenstein, D.R.2    Singh, G.3
  • 5
    • 0036792055 scopus 로고    scopus 로고
    • Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance
    • Ma L, del Soldato P, Wallace JL. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proc Natl Acad Sci USA 2002;99:13243-7.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13243-13247
    • Ma, L.1    del Soldato, P.2    Wallace, J.L.3
  • 6
    • 0038147318 scopus 로고    scopus 로고
    • Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
    • Martel-Pelletier J, Lajeunesse D, Reboul P, Pelletier JP. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis 2003;62: 501-9.
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 501-509
    • Martel-Pelletier, J.1    Lajeunesse, D.2    Reboul, P.3    Pelletier, J.P.4
  • 7
    • 0034949189 scopus 로고    scopus 로고
    • Anti-inflammatory drugs: New multitarget compounds to face an old problem. The dual inhibition concept
    • Celotti F, Laufer S. Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept. Pharmacol Res 2001;43:429-36.
    • (2001) Pharmacol. Res. , vol.43 , pp. 429-436
    • Celotti, F.1    Laufer, S.2
  • 8
    • 0031042347 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
    • Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997;112:1000-1-6.
    • (1997) Gastroenterology , vol.112 , pp. 1000-1016
    • Wallace, J.L.1
  • 9
    • 0036219338 scopus 로고    scopus 로고
    • The mechanism of action of the new antiinflammatory compound ML3000: Inhibition of 5-LOX and COX-1/2
    • Tries S, Neupert W, Laufer S. The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2. Inflamm Res 2002;51:135-43.
    • (2002) Inflamm. Res. , vol.51 , pp. 135-143
    • Tries, S.1    Neupert, W.2    Laufer, S.3
  • 10
    • 23544457281 scopus 로고    scopus 로고
    • Pharmacological profile of ML3000: A new gastric mucosa sparing anti-inflammatory drug with COX/5-LOX inhibitory activity
    • Tries S, Laufer S. Pharmacological profile of ML3000: a new gastric mucosa sparing anti-inflammatory drug with COX/5-LOX inhibitory activity. Inflamm Res 2001;50:S187.
    • (2001) Inflamm. Res. , vol.50
    • Tries, S.1    Laufer, S.2
  • 11
    • 0034946179 scopus 로고    scopus 로고
    • Discovery and development of ML3000
    • Laufer S. Discovery and development of ML3000. Inflammopharmacology 2001;9:101-12.
    • (2001) Inflammopharmacology , vol.9 , pp. 101-112
    • Laufer, S.1
  • 12
    • 0029148708 scopus 로고
    • General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1 H-pyrrolozine-5-yl]-acetic acid in experimental animals
    • Algate DR, Augustin J, Atterson PR et al. General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1 H-pyrrolozine-5-yl]-acetic acid in experimental animals. Arzneimittelforschung 1995;45:159-65.
    • (1995) Arzneimittelforschung , vol.45 , pp. 159-165
    • Algate, D.R.1    Augustin, J.2    Atterson, P.R.3
  • 13
    • 0028597003 scopus 로고
    • ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury
    • Wallace JL, Carter L, McKnight W, Tries S, Laufer S. ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. Eur J Pharmacol 1994;271:525-31.
    • (1994) Eur. J. Pharmacol. , vol.271 , pp. 525-531
    • Wallace, J.L.1    Carter, L.2    McKnight, W.3    Tries, S.4    Laufer, S.5
  • 14
    • 0028322243 scopus 로고
    • Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase
    • Laufer S, Tries S, Augustin J, Dannhardt G. Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase. Arzneimittelforschung 1994;44:629-36.
    • (1994) Arzneimittelforschung , vol.44 , pp. 629-636
    • Laufer, S.1    Tries, S.2    Augustin, J.3    Dannhardt, G.4
  • 15
    • 0029088388 scopus 로고
    • Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid
    • Laufer S, Tries S, Augustin J et al. Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid. Arzneimittelforschung 1995;45:27-32.
    • (1995) Arzneimittelforschung , vol.45 , pp. 27-32
    • Laufer, S.1    Tries, S.2    Augustin, J.3
  • 16
    • 0028675272 scopus 로고
    • Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid in the rat
    • Laufer S, Tries S, Augustin J et al. Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittelforschung 1994;44: 1329-33.
    • (1994) Arzneimittelforschung , vol.44 , pp. 1329-1333
    • Laufer, S.1    Tries, S.2    Augustin, J.3
  • 17
    • 0037990573 scopus 로고    scopus 로고
    • Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after 4 weeks of treatment
    • (Abstract THU0243)
    • Klesser B, Bias P, Buchner A. Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after 4 weeks of treatment. Ann Rheum Dis 2002;61(Suppl. 1) 130 (Abstract THU0243).
    • (2002) Ann. Rheum. Dis. , vol.61 , Issue.SUPPL. 1 , pp. 130
    • Klesser, B.1    Bias, P.2    Buchner, A.3
  • 18
    • 0027525061 scopus 로고
    • A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa
    • Roth SH, Tindall EA, Jain AK et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med 1993;153:2565-71.
    • (1993) Arch. Intern. Med. , vol.153 , pp. 2565-2571
    • Roth, S.H.1    Tindall, E.A.2    Jain, A.K.3
  • 19
    • 0028940475 scopus 로고
    • Endoscopic evaluation of the long term effects of diclofenac sodium and naproxen in elderly patients with arthritis
    • Roth SH, Bennett RE, Caldron PH. Endoscopic evaluation of the long term effects of diclofenac sodium and naproxen in elderly patients with arthritis. Clin Drug Invest 1995;9:171-9.
    • (1995) Clin. Drug Invest. , vol.9 , pp. 171-179
    • Roth, S.H.1    Bennett, R.E.2    Caldron, P.H.3
  • 20
    • 9344236529 scopus 로고    scopus 로고
    • Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
    • Taha AS, Hudson N, Hawkey CJ et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 1996;334:1435-9.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1435-1439
    • Taha, A.S.1    Hudson, N.2    Hawkey, C.J.3
  • 21
    • 0032795602 scopus 로고    scopus 로고
    • An endoscopic study of gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs
    • Cheatum DE, Arvanitakis C, Gumpel M, Stead H, Geis GS. An endoscopic study of gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs. Clin Ther 1999;21:992-1003.
    • (1999) Clin. Ther. , vol.21 , pp. 992-1003
    • Cheatum, D.E.1    Arvanitakis, C.2    Gumpel, M.3    Stead, H.4    Geis, G.S.5
  • 22
    • 23544472526 scopus 로고    scopus 로고
    • Licofelone-a 5-LOX, COX-1 and COX-2 inhibitor-is as effective as naproxen and has improved GI tolerability in patients with osteoarthritis
    • (Abstract 68)
    • Bias P, Buchner A. Licofelone-a 5-LOX, COX-1 and COX-2 inhibitor-is as effective as naproxen and has improved GI tolerability in patients with osteoarthritis. Arthritis Rheum 2003;48(Suppl.):S72 (Abstract 68).
    • (2003) Arthritis Rheum. , vol.48 , Issue.SUPPL.
    • Bias, P.1    Buchner, A.2
  • 23
    • 1042270689 scopus 로고    scopus 로고
    • Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as naproxen and shows improved safety during 12 months of treatment in patients with osteoarthritis of the knee
    • (Abstract FRI0217)
    • Blanco F, Buchner A, Bias P, Lammerich A, Schulz U. Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as naproxen and shows improved safety during 12 months of treatment in patients with osteoarthritis of the knee. Ann Rheum Dis 2003;62(Suppl. 1):262 (Abstract FRI0217).
    • (2003) Ann. Rheum. Dis. , vol.62 , Issue.SUPPL. 1 , pp. 262
    • Blanco, F.1    Buchner, A.2    Bias, P.3    Lammerich, A.4    Schulz, U.5
  • 24
    • 1042270689 scopus 로고    scopus 로고
    • Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with OA of the knee
    • (Abstract FRI0215)
    • Pavelka K, Bias P, Buchner A, Lammerich A, Schulz U. Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with OA of the knee. Ann Rheum Dis 2003;62(Suppl. 1):261 (Abstract FRI0215).
    • (2003) Ann. Rheum. Dis. , vol.62 , Issue.SUPPL. 1 , pp. 261
    • Pavelka, K.1    Bias, P.2    Buchner, A.3    Lammerich, A.4    Schulz, U.5
  • 25
    • 0035992958 scopus 로고    scopus 로고
    • Controversies in COX-2 selective inhibition
    • Simon LS, Smolen JS, Abramson SB et al. Controversies in COX-2 selective inhibition. J Rheumatol 2002;29:1501-10.
    • (2002) J. Rheumatol. , vol.29 , pp. 1501-1510
    • Simon, L.S.1    Smolen, J.S.2    Abramson, S.B.3
  • 26
    • 0038012992 scopus 로고    scopus 로고
    • Does cyclooxygenase-2 affect blood pressure?
    • Cheng HF, Harris RC. Does cyclooxygenase-2 affect blood pressure? Curr Hypertens Rep 2003;5:87-92.
    • (2003) Curr. Hypertens. Rep. , vol.5 , pp. 87-92
    • Cheng, H.F.1    Harris, R.C.2
  • 27
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study
    • Silverstein FE, Faich G, Goldstein JL et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 2000;284:1247-55.
    • (2000) JAMA , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3
  • 28
    • 0035044885 scopus 로고    scopus 로고
    • Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis
    • Goldstein JL, Correa P, Zhao WW et al. Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. Am J Gastroenterol 2001;96:1019-27.
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 1019-1027
    • Goldstein, J.L.1    Correa, P.2    Zhao, W.W.3
  • 29
    • 0038718727 scopus 로고    scopus 로고
    • Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    • Fiorucci S, Distrutti E, de Lima OM et al. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J 2003;17:1171-3.
    • (2003) FASEB J. , vol.17 , pp. 1171-1173
    • Fiorucci, S.1    Distrutti, E.2    de Lima, O.M.3
  • 30
    • 23544472526 scopus 로고    scopus 로고
    • Licofelone - An inhibitor of 5-LOX, COX-1 and COX-2 has superior GI tolerability in OA patients compared with naproxen, regardless of low-dose aspirin co-medication, previous ulcer history or H. pylori status
    • (Abstract 67)
    • Bias P, Buchner A. Licofelone - an inhibitor of 5-LOX, COX-1 and COX-2 has superior GI tolerability in OA patients compared with naproxen, regardless of low-dose aspirin co-medication, previous ulcer history or H. pylori status. Arthritis Rheum 2003;48(Suppl.):S72 (Abstract 67).
    • (2003) Arthritis Rheum. , vol.48 , Issue.SUPPL.
    • Bias, P.1    Buchner, A.2


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