-
1
-
-
0031680203
-
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
-
Simon LS, Lanza FL, Lipsky PE et al. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum 1998;41:1591-602.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1591-1602
-
-
Simon, L.S.1
Lanza, F.L.2
Lipsky, P.E.3
-
2
-
-
0035722949
-
Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors
-
Komers R, Anderson S, Epstein M. Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors. Am J Kidney Dis 2001;38:1145-57.
-
(2001)
Am. J. Kidney Dis.
, vol.38
, pp. 1145-1157
-
-
Komers, R.1
Anderson, S.2
Epstein, M.3
-
4
-
-
0033577982
-
Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
-
Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999;340: 1888-99.
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1888-1899
-
-
Wolfe, M.M.1
Lichtenstein, D.R.2
Singh, G.3
-
5
-
-
0036792055
-
Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance
-
Ma L, del Soldato P, Wallace JL. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proc Natl Acad Sci USA 2002;99:13243-7.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13243-13247
-
-
Ma, L.1
del Soldato, P.2
Wallace, J.L.3
-
6
-
-
0038147318
-
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
-
Martel-Pelletier J, Lajeunesse D, Reboul P, Pelletier JP. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis 2003;62: 501-9.
-
(2003)
Ann. Rheum. Dis.
, vol.62
, pp. 501-509
-
-
Martel-Pelletier, J.1
Lajeunesse, D.2
Reboul, P.3
Pelletier, J.P.4
-
7
-
-
0034949189
-
Anti-inflammatory drugs: New multitarget compounds to face an old problem. The dual inhibition concept
-
Celotti F, Laufer S. Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept. Pharmacol Res 2001;43:429-36.
-
(2001)
Pharmacol. Res.
, vol.43
, pp. 429-436
-
-
Celotti, F.1
Laufer, S.2
-
8
-
-
0031042347
-
Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
-
Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997;112:1000-1-6.
-
(1997)
Gastroenterology
, vol.112
, pp. 1000-1016
-
-
Wallace, J.L.1
-
9
-
-
0036219338
-
The mechanism of action of the new antiinflammatory compound ML3000: Inhibition of 5-LOX and COX-1/2
-
Tries S, Neupert W, Laufer S. The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2. Inflamm Res 2002;51:135-43.
-
(2002)
Inflamm. Res.
, vol.51
, pp. 135-143
-
-
Tries, S.1
Neupert, W.2
Laufer, S.3
-
10
-
-
23544457281
-
Pharmacological profile of ML3000: A new gastric mucosa sparing anti-inflammatory drug with COX/5-LOX inhibitory activity
-
Tries S, Laufer S. Pharmacological profile of ML3000: a new gastric mucosa sparing anti-inflammatory drug with COX/5-LOX inhibitory activity. Inflamm Res 2001;50:S187.
-
(2001)
Inflamm. Res.
, vol.50
-
-
Tries, S.1
Laufer, S.2
-
11
-
-
0034946179
-
Discovery and development of ML3000
-
Laufer S. Discovery and development of ML3000. Inflammopharmacology 2001;9:101-12.
-
(2001)
Inflammopharmacology
, vol.9
, pp. 101-112
-
-
Laufer, S.1
-
12
-
-
0029148708
-
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1 H-pyrrolozine-5-yl]-acetic acid in experimental animals
-
Algate DR, Augustin J, Atterson PR et al. General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1 H-pyrrolozine-5-yl]-acetic acid in experimental animals. Arzneimittelforschung 1995;45:159-65.
-
(1995)
Arzneimittelforschung
, vol.45
, pp. 159-165
-
-
Algate, D.R.1
Augustin, J.2
Atterson, P.R.3
-
13
-
-
0028597003
-
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury
-
Wallace JL, Carter L, McKnight W, Tries S, Laufer S. ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. Eur J Pharmacol 1994;271:525-31.
-
(1994)
Eur. J. Pharmacol.
, vol.271
, pp. 525-531
-
-
Wallace, J.L.1
Carter, L.2
McKnight, W.3
Tries, S.4
Laufer, S.5
-
14
-
-
0028322243
-
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase
-
Laufer S, Tries S, Augustin J, Dannhardt G. Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase. Arzneimittelforschung 1994;44:629-36.
-
(1994)
Arzneimittelforschung
, vol.44
, pp. 629-636
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
Dannhardt, G.4
-
15
-
-
0029088388
-
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid
-
Laufer S, Tries S, Augustin J et al. Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid. Arzneimittelforschung 1995;45:27-32.
-
(1995)
Arzneimittelforschung
, vol.45
, pp. 27-32
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
-
16
-
-
0028675272
-
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid in the rat
-
Laufer S, Tries S, Augustin J et al. Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H -pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittelforschung 1994;44: 1329-33.
-
(1994)
Arzneimittelforschung
, vol.44
, pp. 1329-1333
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
-
17
-
-
0037990573
-
Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after 4 weeks of treatment
-
(Abstract THU0243)
-
Klesser B, Bias P, Buchner A. Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after 4 weeks of treatment. Ann Rheum Dis 2002;61(Suppl. 1) 130 (Abstract THU0243).
-
(2002)
Ann. Rheum. Dis.
, vol.61
, Issue.SUPPL. 1
, pp. 130
-
-
Klesser, B.1
Bias, P.2
Buchner, A.3
-
18
-
-
0027525061
-
A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa
-
Roth SH, Tindall EA, Jain AK et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med 1993;153:2565-71.
-
(1993)
Arch. Intern. Med.
, vol.153
, pp. 2565-2571
-
-
Roth, S.H.1
Tindall, E.A.2
Jain, A.K.3
-
19
-
-
0028940475
-
Endoscopic evaluation of the long term effects of diclofenac sodium and naproxen in elderly patients with arthritis
-
Roth SH, Bennett RE, Caldron PH. Endoscopic evaluation of the long term effects of diclofenac sodium and naproxen in elderly patients with arthritis. Clin Drug Invest 1995;9:171-9.
-
(1995)
Clin. Drug Invest.
, vol.9
, pp. 171-179
-
-
Roth, S.H.1
Bennett, R.E.2
Caldron, P.H.3
-
20
-
-
9344236529
-
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
-
Taha AS, Hudson N, Hawkey CJ et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 1996;334:1435-9.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1435-1439
-
-
Taha, A.S.1
Hudson, N.2
Hawkey, C.J.3
-
21
-
-
0032795602
-
An endoscopic study of gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs
-
Cheatum DE, Arvanitakis C, Gumpel M, Stead H, Geis GS. An endoscopic study of gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs. Clin Ther 1999;21:992-1003.
-
(1999)
Clin. Ther.
, vol.21
, pp. 992-1003
-
-
Cheatum, D.E.1
Arvanitakis, C.2
Gumpel, M.3
Stead, H.4
Geis, G.S.5
-
22
-
-
23544472526
-
Licofelone-a 5-LOX, COX-1 and COX-2 inhibitor-is as effective as naproxen and has improved GI tolerability in patients with osteoarthritis
-
(Abstract 68)
-
Bias P, Buchner A. Licofelone-a 5-LOX, COX-1 and COX-2 inhibitor-is as effective as naproxen and has improved GI tolerability in patients with osteoarthritis. Arthritis Rheum 2003;48(Suppl.):S72 (Abstract 68).
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.SUPPL.
-
-
Bias, P.1
Buchner, A.2
-
23
-
-
1042270689
-
Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as naproxen and shows improved safety during 12 months of treatment in patients with osteoarthritis of the knee
-
(Abstract FRI0217)
-
Blanco F, Buchner A, Bias P, Lammerich A, Schulz U. Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as naproxen and shows improved safety during 12 months of treatment in patients with osteoarthritis of the knee. Ann Rheum Dis 2003;62(Suppl. 1):262 (Abstract FRI0217).
-
(2003)
Ann. Rheum. Dis.
, vol.62
, Issue.SUPPL. 1
, pp. 262
-
-
Blanco, F.1
Buchner, A.2
Bias, P.3
Lammerich, A.4
Schulz, U.5
-
24
-
-
1042270689
-
Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with OA of the knee
-
(Abstract FRI0215)
-
Pavelka K, Bias P, Buchner A, Lammerich A, Schulz U. Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with OA of the knee. Ann Rheum Dis 2003;62(Suppl. 1):261 (Abstract FRI0215).
-
(2003)
Ann. Rheum. Dis.
, vol.62
, Issue.SUPPL. 1
, pp. 261
-
-
Pavelka, K.1
Bias, P.2
Buchner, A.3
Lammerich, A.4
Schulz, U.5
-
26
-
-
0038012992
-
Does cyclooxygenase-2 affect blood pressure?
-
Cheng HF, Harris RC. Does cyclooxygenase-2 affect blood pressure? Curr Hypertens Rep 2003;5:87-92.
-
(2003)
Curr. Hypertens. Rep.
, vol.5
, pp. 87-92
-
-
Cheng, H.F.1
Harris, R.C.2
-
27
-
-
0034644396
-
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study
-
Silverstein FE, Faich G, Goldstein JL et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 2000;284:1247-55.
-
(2000)
JAMA
, vol.284
, pp. 1247-1255
-
-
Silverstein, F.E.1
Faich, G.2
Goldstein, J.L.3
-
28
-
-
0035044885
-
Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis
-
Goldstein JL, Correa P, Zhao WW et al. Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. Am J Gastroenterol 2001;96:1019-27.
-
(2001)
Am. J. Gastroenterol.
, vol.96
, pp. 1019-1027
-
-
Goldstein, J.L.1
Correa, P.2
Zhao, W.W.3
-
29
-
-
0038718727
-
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
-
Fiorucci S, Distrutti E, de Lima OM et al. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J 2003;17:1171-3.
-
(2003)
FASEB J.
, vol.17
, pp. 1171-1173
-
-
Fiorucci, S.1
Distrutti, E.2
de Lima, O.M.3
-
30
-
-
23544472526
-
Licofelone - An inhibitor of 5-LOX, COX-1 and COX-2 has superior GI tolerability in OA patients compared with naproxen, regardless of low-dose aspirin co-medication, previous ulcer history or H. pylori status
-
(Abstract 67)
-
Bias P, Buchner A. Licofelone - an inhibitor of 5-LOX, COX-1 and COX-2 has superior GI tolerability in OA patients compared with naproxen, regardless of low-dose aspirin co-medication, previous ulcer history or H. pylori status. Arthritis Rheum 2003;48(Suppl.):S72 (Abstract 67).
-
(2003)
Arthritis Rheum.
, vol.48
, Issue.SUPPL.
-
-
Bias, P.1
Buchner, A.2
|