Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function

European Journal of Pharmacology

Volumn 453, Issue 1, 2002, Pages 131-139

  Rotondo, Serenella ^a   Dell'Elba, Giuseppe ^a   Krauze Brzósko, Katarzyna ^a   Manarini, Stefano ^a   Martelli, Nicola ^a   Pecce, Romina ^a   Evangelista, Virgilio ^a   Cerletti, Chiara ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

5 Lipoxygenase; Adhesive interaction; Cyclooxygenase; Inflammation; Polymorphonuclear leukocyte, human; Transcellular metabolism

Indexed keywords

ARACHIDONIC ACID; CALCIMYCIN; COMPLEMENT COMPONENT C5A; ELASTASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HYDROXYICOSATETRAENOIC ACID; LEUKOTRIENE A4; LEUKOTRIENE C4; LICOFELONE; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; THROMBOCYTE ACTIVATING FACTOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; CELL INTERACTION; CELL METABOLISM; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME RELEASE; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; INHIBITION KINETICS; LEUKOCYTE AGGREGATION; NEUTROPHIL; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; SUSPENSION; THROMBOCYTE FUNCTION;

ACETIC ACIDS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; NEUTROPHILS; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES;

EID: 0037130991     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02385-3     Document Type: Article

References (37)

1. Abraham W.M., Laufer S., Tries S. The effects of ML3000 on antigen-induced responses in sheep. Pulm. Pharmacol. Ther. 10:1997;167-173.
2. Algate D.R., Augustin J., Atterson P.R., Beard D.J., Jobling C.M., Laufer S., Munt P.L., Tries S. General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals. Arzneimittelforschung. 45:1995;159-165.
3. Arnaout M.A. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood. 75:1990;1037-1050.
4. Bazzoni G., Dejana E., Del Maschio A. Adrenergic modulation of human polymorphonuclear leukocyte activation. Potentiating effect of adenosine. Blood. 77:1991;2042-2048.
5. Brady H.R., Serhan C.N. Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin. Biochem. Biophys. Res. Commun. 186:1992;1307-1314.
6. 4 in urine of rabbit by reversed-phase high-performance liquid chromatography. J. Chromatogr. 658:1994;261-269.
7. Cerletti C., Evangelista V., de Gaetano G. P-selectin-beta 2-integrin cross-talk: a molecular mechanism for polymorphonuclear leukocyte recruitment at the site of vascular damage. Thromb. Haemost. 82:1999;787-793.
8. Croset M., Lagarde M. Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids. Biochem. Biophys. Res. Commun. 112:1983;878-883.
9. Cuzzocrea S., Riley D.P., Caputi A.P., Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 53:2001;135-159.
10. 14C]-acetic acid in rats. Arzneimittelforschung. 45:1995;272-276.
11. Diaz-Gonzalez F., Gonzalez-Alvaro I., Campanero M.R., Mollinedo F., del Pozo M.A., Munoz C., Pivel J.P., Sanchez-Madrid F. Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs. J. Clin. Invest. 95:1995;1756-1765.
12. Doring G. The role of neutrophil elastase in chronic inflammation. Am. J. Respir. Crit. Care Med. 150:1994;S114-S117.
13. Evangelista V., Rajtar G., de Gaetano G., White J.G., Cerletti C. Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases. Blood. 77:1991;2379-2388.
14. Evangelista V., Manarini S., Rotondo S., Martelli N., Polishuk R., McGregor J.L., de Gaetano G., Cerletti C. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the β2-integrin CD11b/CD18. Blood. 88:1996;4183-4194.
15. Evangelista V., Celardo A., Dell'Elba G., Manarini S., Mironov A., de Gaetano G., Cerletti C. Platelet contribution to leukotriene production in inflammation: in vivo evidence in the rabbit. Thromb. Haemost. 81:1999;442-448.
16. Finkel T. Oxygen radicals and signaling. Curr. Opin. Cell Biol. 10:1998;248-253.
17. Hatzelmann A., Fruchtmann R., Mohrs K.H., Raddatz S., Muller-Peddinghaus R. Mode of action of the new selective leukotriene synthesis inhibitor BAY-X1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. Biochem. Pharmacol. 45:1993;101-111.
18. 2+ ionophore A23187-stimulated secretion of azurophil granules in human polymorphonuclear leukocytes is largely mediated by endogenously formed leukotriene B4. Biochem. Pharmacol. 48:1994;31-39.
19. Henderson W.R. Jr. The role of leukotrienes in inflammation. Ann. Intern. Med. 121:1994;684-697.
20. Laufer S., Augustin J., Dannhardt G., Kiefer W. (6,7-Diaryldihydropyrrolizin-5-yl) acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J. Med. Chem. 37:1994;1894-1897.
21. Laufer S., Tries S., Augustin J., Dannhardt G. Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclooxygenase and 5-lipoxygenase. Arzneimittelforschung. 44:1994;629-636.
22. Laufer S., Tries S., Augustin J., Elsaßer R., Algate D.R., Atterson P.R., Munt P.L. Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittelforschung. 12:1994;1329-1333.
23. Laufer S., Tries S., Augustin J., Elsaßer R., Albrecht W., Guserle R., Algate D.R., Atterson P.R., Munt P.L. Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4-chlorophenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittelforschung. 45:1995;27-32.
24. Lewis R.A., Austen K.F., Soberman R.J. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. New Engl. J. Med. 323:1990;645-655.
25. Mais D.E., Saussy D.L. Jr., Magee D.E., Bowling N.L. Interaction of 5-HETE, 12-HETE, 15-HETE and 5,12-diHETE at the human platelet thromboxane A2/prostaglandin H2 receptor. Eicosanoids. 3:1990;121-124.
26. Marcus A.J., Broekman M.J., Safier L.B., Ullman H.L., Islam N., Sherhan C.N., Rutherford L.E., Korchak H.M., Weissmann G. Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem. Biophys. Res. Commun. 109:1982;130-137.
27. Maugeri N., Evangelista V., Piccardoni P., Dell'Elba G., Celardo A., de Gaetano G., Cerletti C. Transcellular metabolism of arachidonic acid: increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes. Blood. 80:1992;447-451.
28. 4 cooperative synthesis. Thromb. Haemost. 72:1994;450-456.
29. Palmantier R., Borgeat P. Transcellular metabolism of arachidonic acid in platelets and polymorphonuclear leukocytes activated by physiological agonists: enhancement of leukotriene B4 synthesis. Adv. Exp. Med. Biol. 314:1991;73-89.
30. Pillinger M.H., Capodici C., Rosenthal P., Kheterpal N., Hanft S., Philips M.R., Weissmann G. Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. Proc. Natl. Acad. Sci. U. S. A. 95:1998;14540-14545.
31. Todd P.A., Sorkin E.M. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 35:1988;244-285.
32. Tonnesen M.G., Anderson D.C., Springer T.A., Knedler A., Avdi N., Henson P.M. Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family. J. Clin. Invest. 83:1989;637-646.
33. Totani L., Cumashi A., Piccoli A., Lorenzet R. Polymorphonuclear leukocytes induce PDGF release from IL-1 beta-treated endothelial cells: role of adhesion molecules and serine proteases. Arterioscler. Thromb. Vasc. Biol. 18:1998;1534-1540.
34. Vaday G.G., Lider O. Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation. J. Leukoc. Biol. 67:2000;149-159.
35. Wallace J.L., Carter L., McKnight W., Tries S., Laufer S. ML3000 reduces gastric prostaglandin synthesis without causing mucosal injury. Eur. J. Pharmacol. 271:1994;525-531.
36. Werner U., Seitz O., Szelenyi I. Stimulated elastase release from human leukocytes: influence of anti-asthmatic, anti-inflammatory and calcium antagonist drugs in vitro. Agents Actions. 38:1993;C112-C114.
37. Zhou L., Pope B.L., Chourmouzis E., Fung-Leung W.P., Lau C.Y. Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression. Eur. J. Immunol. 26:1996;120-129.