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Volumn 20, Issue 15, 2012, Pages 4710-4715

Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands

(11) Schann, Stephan a,b Greney, Hugues a Gasparik, Vincent a Dontenwill, Monique a Rascente, Carla a Lacroix, Gabriel a Monassier, Laurent a Bruban, Véronique a Feldman, Josiane a Ehrhardt, Jean Daniel a Bousquet, Pascal a

a UNIVERSITÉ DE STRASBOURG (France)

b Domain Therapeutics (France)

Author keywords

Alpha2 adrenoceptor; Clonidine; Hypotensive agents; Imidazolines; Rilmenidine

Indexed keywords

(2 CHLOROPHENYL) (5 METHYL 4,5 DIHYDRO 3H PYRROL 2 YL)AMINE; (2,6 DICHLOROPHENYL) (4 METHYL 4,5 DIHYDRO 1H IMIDAZOL 2 YL)AMINE; 2,6 DICHLORO 1 DICHLOROISOCYANOBENZENE; ALPHA 2 ADRENERGIC RECEPTOR; AMINOPYRROLINE; CLONIDINE; DICYCLOPROPYLMETHYL (4 METHYL 4,5 DIHYDROOXAZOL 2 YL)AMINE; DICYCLOPROPYLMETHYL CARBAMIC ACID PHENYL ESTER; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE I1 RECEPTOR; LNP 509; LNP 630; LNP 911; N (2,6 DICHLOROPHENYL)FORMAMIDE; RILMENIDINE; SD 067; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTENSION; IODINATION; ISOTOPE LABELING; MALE; METHYLATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; VASOCONSTRICTION;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HUMANS; IMIDAZOLINE RECEPTORS; IMIDAZOLINES; INJECTIONS, INTRAVENOUS; LIGANDS; MALE; METHYLATION; MOLECULAR STRUCTURE; PC12 CELLS; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863984849 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.06.008 Document Type: Article

Times cited : (14)

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