α2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 32-40

  Gentili, F ^a   Bousquet, P ^b   Brasili, L ^c   Caretto, M ^a   Carrieri, A ^d   Dontenwill, M ^b   Giannella, M ^a   Marucci, G ^a   Perfumi, M ^a   Piergentili, A ^a   Quaglia, W ^a   Rascente, C ^b   Pigini, M ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 [1 (BIPHENYL 2 YLOXY)ETHYL] 4,5 DIHYDRO 1H IMIDAZOLE; 2 [3 EXO (3 PHENYLPROP 1 YL) 2 EXO NORBORNYL]AMINO 2 OXAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; CIRAZOLINE; IMIDAZOLINE I2 RECEPTOR; UNCLASSIFIED DRUG; 2 (1 (BIPHENYL 2 YLOXY)ETHYL) 4,5 DIHYDRO 1H IMIDAZOLE; 2-(1-(BIPHENYL-2-YLOXY)ETHYL)-4,5-DIHYDRO-1H-IMIDAZOLE; 2-METHOXYIDAZOXAN; ADRENERGIC ALPHA AGONISTS; ADRENERGIC ALPHA ANTAGONISTS; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; BIPHENYL DERIVATIVE; DRUG DERIVATIVE; DRUG RECEPTOR; IDAZOXAN; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTOR; RECEPTORS, ADRENERGIC, ALPHA 2;

ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST; VAS DEFERENS; ANIMAL; BINDING COMPETITION; BRAIN CORTEX; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; IN VITRO STUDY; KIDNEY; METABOLISM; PHYSIOLOGY; RABBIT; RADIOASSAY; STEREOISOMERISM; SYNTHESIS;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANIMAL; BINDING, COMPETITIVE; BIPHENYL COMPOUNDS; CELL LINE; CEREBRAL CORTEX; HUMAN; IDAZOXAN; IMIDAZOLES; IN VITRO; KIDNEY; MALE; MICE; MODELS, MOLECULAR; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VAS DEFERENS;

EID: 0037011792     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110082     Document Type: Article

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