Structure-activity relationships on adrenoceptors and imidazoline-preferring binding sites (I1,2-PBSs). Part 1: Weak intramolecular H-bond and conformational flexibility in a new I1-PBS-selective imidazoline analogue, trans1-(4',5'-dihydro-1'H-imidazol-2'-yl)methyl-2-hydroxyindane (PMS 952)

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 8, 2000, Pages 1861-1869

  Ye, H F ^a   Dive, G ^b   Dehareng, D ^b   Heymans, F ^a   Godfroid, J J ^a  

^a Laboratoire de Pharmacochimie   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; IMIDAZOLE DERIVATIVE; PMS 952; TRANS 1 (4',5' DIHYDRO 1' H IMIDAZOL 2' YL)METHYL 2 HYDROXYINDANE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG CONFORMATION; MOLECULAR BIOLOGY; MOLECULE; NONHUMAN; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANIMALS; BINDING SITES; BRAIN CHEMISTRY; CATTLE; DIMERIZATION; HYDROGEN BONDING; IMIDAZOLES; KIDNEY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RABBITS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033859989     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00115-2     Document Type: Article

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