A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system

Neuropsychopharmacology

Volumn 37, Issue 9, 2012, Pages 1986-1998

  Berger, Stefan M ^a   Weber, Tillmann ^a   Perreau Lenz, Stephanie ^a   Vogt, Miriam A ^a   Gartside, Sarah E ^b   Maser Gluth, Christiane ^a   Lanfumey, Laurence ^c   Gass, Peter ^a   Spanagel, Rainer ^a   Bartsch, Dusan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c INSERM   (France)

Author keywords

5 HT1A receptor; anxiety; depression; serotonin; SSRI; TPH2

Indexed keywords

AUTORECEPTOR; CORTICOSTERONE; DOPAMINE; ESCITALOPRAM; SEROTONIN; SEROTONIN 1A RECEPTOR;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FOREBRAIN; GENE; GENOTYPE; HIPPOCAMPUS; MALE; MESENCEPHALON; MOUSE; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE; TRANQUILIZING ACTIVITY; TRYPTOPHAN HYDROXYLASE 2 GENE;

ANIMALS; ANXIETY; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 84863984205     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.46     Document Type: Article

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