The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses

Genes, Brain and Behavior

Volumn 5, Issue 1, 2006, Pages 107-110

  De Luca, V ^a   Hlousek, D ^a   Likhodi, O ^a   Van Tol, H H M ^a   Kennedy, J L ^a   Wong, A H C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Covariate; Haplotype; Psychoses; Suicide; TPH2

Indexed keywords

GENOMIC DNA; ISOPROTEIN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG; ADENINE; CYTOSINE; ENZYME; TRYPTOPHAN HYDROXYLASE ISOFORM 2;

ADULT; ARTICLE; AUTOMATION; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE AMPLIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PSYCHOSIS; SCHIZOPHRENIA; SUICIDE; AMINO ACID SUBSTITUTION; COVARIANCE; DNA POLYMORPHISM; ENZYME LOCALIZATION; GENE INTERACTION; GENETIC ASSOCIATION; HUMAN TISSUE; MARKER GENE; SEROTONINERGIC NERVE CELL; SUICIDAL IDEATION;

ADULT; BIPOLAR DISORDER; FEMALE; HAPLOTYPES; HUMANS; ISOENZYMES; LINKAGE (GENETICS); MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; SCHIZOPHRENIA; SUICIDE; TRYPTOPHAN HYDROXYLASE;

EID: 33645046359     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00182.x     Document Type: Article

References (22)

1. Asberg M. Traskman L. Thoren P. 1976 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33 1193 1197
2. American Psychiatric Association 1994 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition American Psychiatric Association Washington DC
3. Chen Y.W. Dilsaver S.C. 1996 Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders Biol Psychiatry 39 896 899
4. Dalton E.J. Cate-Carter T.D. Mundo E. Parikh S.V. Kennedy J.L. 2003 Suicide risk in bipolar patients: the role of co-morbid substance use disorders Bipolar Disord 5 58 61
5. Fitzpatrick P.F. 1999 Tetrahydropterin-dependent amino acid hydroxylases Annu Rev Biochem 68 355 381
6. Goodwin F.K. Jaminson K.R. 1990 Manic Depressive - A Definitive Overview of Bipolar Disorder Oxford University Press New York
7. Kennedy M.A. Miller A.L. Rogers G. Luty S. Mulder R. Joyce P. 2003 Polymorphic variants and association analysis of TPH2, brain tryptophan hydroxylase Neuropsychiatric Genet 122B 69
8. Lalovic A. Turecki G. 2002 Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior Am J Med Genet 114B 533 540
9. Mann J.J. 1995 Violence and aggression. In: Bloom F.E. Kupfer D.J. (eds) Psychopharmacology: The Fourth Generation of Progress Raven Press New York, pp. 1919-19 28
10. Meltzer H.Y. 2005 Suicide in schizophrenia, clozapine and adoption of evidence-based medicine J Clin Psychiatry 66 530 533
11. Nielsen D.A. Virkkunen M. Lappalainen J. Eggert M. Brown G.L. Long J.C. Goldman D. Linnoila M. 1998 A tryptophan hydroxylase gene marker for suicidality and alcoholism Arch Gen Psychiatry 55 593 602
12. Nordstrom P. Samuelsson M. Asberg M. Traskman-Bendz L. Aberg-Wistedt A. Nordin C. Bertilsson L. 1994 CSF 5-HIAA predicts suicide risk after attempted suicide Suicide Life Threat Behav 24 1 9
13. Roy A. 1993 Genetic and biologic risk factors for suicide in depressive disorders Psychiatr Q 64 345 358
14. Rujescu D. Giegling I. Sato T. Hartmann A.M. Moller H.J. 2003 Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis Biol Psychiatry 54 465 473
15. Seltman H. Roeder K. Devlin B. 2003 Evolutionary-based association analysis using haplotype data Genet Epidemiol 25 48 58
16. Stack S. 2000 Suicide: a 15-year review of the sociological literature. Part I: cultural and economic factors Suicide Life Threat Behav 30 145 162
17. Walther D.J. Bader M. 2003 A unique central tryptophan hydroxylase isoform Biochem Pharmacol 66 1673 1680
18. Walther D.J. Peter J.U. Bashammakh S. Hortnagl H. Voits M. Fink H. Bader M. 2003 Synthesis of serotonin by a second tryptophan hydroxylase isoform Science 299 76
19. Weiss K.M. Terwilliger J.D. 2000 How many diseases does it take to map a gene with SNPs? Nat Genet 26 151 157
20. Zill P. Buttner A. Eisenmenger W. Bondy B. Ackenheil M. 2004a Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains Eur Neuropsychopharmacol 14 282 284
21. Zill P. Baghai T.C. Zwanzger P. Schule C. Eser D. Rupprecht R. Moller H.J. Bondy B. Ackenheil M. 2004b SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression Mol Psychiatry 9 1030 1036
22. Zill P. Buttner A. Eisenmenger W. Moller H.J. Bondy B. Ackenheil M. 2004c Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims Biol Psychiatry 56 581 586