SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide

Neuropsychopharmacology

Volumn 32, Issue 8, 2007, Pages 1687-1694

  Zill, Peter ^a   Preuss, Ulrich W ^a,b   Koller, Gabrielle ^a   Bondy, Brigitta ^a   Soyka, Michael ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Alcoholism; Association study; Haplotypes; Polymorphism; Suicide; Tryptophan hydroxylase

Indexed keywords

TRYPTOPHAN HYDROXYLASE 2;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE; SUICIDE ATTEMPT;

ADULT; ALCOHOL-RELATED DISORDERS; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SUICIDE; TRYPTOPHAN HYDROXYLASE;

EID: 34447504059     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301318     Document Type: Article

References (47)

1. Anghelescu I, Klawe C, Fehr C, Singer P, Schleicher A, Himmerich H et al (2005). The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology. Addict Behav 30: 1135-1143.
2. Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS et al (1992). Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49: 599-608.
3. Banki CM (1981). Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J Neural Transm 50: 89-101.
4. Bottlender M, Preuss UW, Soyka M (2006). Association of personality disorders with Type A and Type B alcoholics. Eur Arch Psychiatry Clin Neurosci 256: 55-61.
5. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE et al (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10: 884-888.
6. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI et al (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55: 149-158.
7. Cardon LR, Palmer LJ (2003). Population stratification and spurious allelic association. Lancet 361: 598-604.
8. Cloninger CR, Sigvardsson S, Gilligan SB, von Knorring AL, Reich T, Bohman M (1988). Genetic heterogeneity and the classification of alcoholism. Adv Alcohol Subst Abuse 7: 3-16.
9. Courtet P, Jollant F, Castelnau D, Buresi C, Malafosse A (2005). Suicidal behavior: relationship between phenotype and serotonergic genotype. Am J Med Genet C Semin Med Genet 133: 25-33.
10. Dick DM, Foroud T (2003). Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 27: 868-879.
11. Dudbridge F (2003). Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25: 115-121.
12. Edenberg HJ, Foroud T (2006). The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 11: 386-396.
13. Fehr C, Schleicher A, Szegedi A, Anghelescu I, Klawe C, Hiemke C et al (2001). Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry 25: 965-982.
14. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al (2002). The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
15. Harvey M, Shink E, Tremblay M, Gagne B, Raymond C, Labbe M et al (2004). Support for the involvement of TPH2 gene in affective disorders. Mol Psychiatry 9: 980-981.
16. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999). A validity study of the SSAGA-a comparison with the SCAN. Addiction 94: 1361-1370.
17. Keppel S, Dilg C, Franke P (2001). Test-retest and interrater-reliability of the semistructured interview of alcohol and drug addiction (SIGAD). Suchtmedizin 3: 217-223.
18. Koller G, Engel R, Preuss U, Karakesisoglou A, Zill P, Bondy B et al (2005). Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals. Addict Biol 10: 269-273.
19. Kruglyak L (1999). Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet 22: 139-144.
20. LeMarquand D, Pihl RO, Benkelfat C (1994). Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 36: 326-337.
21. Lewontin RC (1988). On measures of gametic disequilibrium. Genetics 120: 849-852.
22. Maffei C, Fossati A, Agostoni I, Barraco A, Bagnato M, Deborah D et al (1997). Interrater reliability and internal consistency of the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), version 2.0. J Personality Disorders 11: 279-284.
23. Mestel R, Wäschenbach T, Lutze C (2001). Interraterreliabilität für das SKID-II für Persönlichkeitsstörungen nach DSM-IV. In: DGPs (Hrsg). Psychologie 2000. Pabst Science Publishers: Lengerich.
24. Murphy DL (1990). Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems. Neuropsychopharmacology 3: 457-471.
25. Murphy GE, Wetzel RD (1990). The lifetime risk of suicide in alcoholism. Arch Gen Psychiatry 47: 383-392.
26. Naranjo CA, Sellers EM, Lawrin MO (1986). Modulation of ethanol intake by serotonin uptake inhibitors. J Clin Psychiatry 47(Suppl): 16-22.
27. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC et al (1998). A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55: 593-602.
28. Parsian A, Cloninger CR (2001). Serotonergic pathway genes and subtypes of alcoholism: association studies. Psychiatr Genet 11: 89-94.
29. Preuss UW, Schuckit MA, Smith TL, Danko GP, Buckman K, Bierut L et al (2002). Comparison of 3190 alcohol-dependent individuals with and without suicide attempts. Alcohol Clin Exp Res 26: 471-477.
30. Purcell S, Cherny SS, Sham PC (2003). Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150.
31. Rice JP, Reich T, Bucholz KK, Neuman RJ, Fishman R, Rochberg N et al (1995). Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res 19: 1018-1023.
32. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ et al (2001). Linkage disequilibrium in the human genome. Nature 411: 199-204.
33. Schulze TG, McMahon FJ (2002). Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am J Med Genet 114: 1-11.
34. Sham PC, Curtis D (1995). Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59(Part 1): 97-105.
35. Stephens M, Smith NJ, Donnelly P (2001). A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68: 978-989.
36. Thompson EA, Deeb S, Walker D, Motulsky AG (1988). The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. Am J Hum Genet 42: 113-124.
37. Turner D, Choudhury F, Reynard M, Railton D, Navarrete C (2002). Typing of multiple single nucleotide polymorphisms in cytokine and receptor genes using SNaPshot. Hum Immunol 63: 508-513.
38. Virkkunen M, Linnoila M (1997). Serotonin in early-onset alcoholism. Recent Dev Alcohol 13: 173-189.
39. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H et al (2003). Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299: 76.
40. Wittchen HU, Zaudig M, Fydrich T (1997). SKID-I/II: Strukturiertes klinisches Interview für DSM-IV. Hogrefe: Göttingen.
41. Zanarini MC, Skodol AE, Bender D, Dolan R, Sanislow C, Schaefer E et al (2000). The Collaborative Longitudinal Personality Disorders Study: reliability of axis I and II diagnoses. J Personality Disorders 14: 291-299.
42. Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB et al (2005). Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45: 11-16.
43. Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J et al (2005). Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 62: 1109-1118.
44. Zill P, Baghai TC, Zwanzger P, Schule C, Eser D, Rupprecht R et al (2004a). SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 9: 1030-1036.
45. Zill P, Buttner A, Eisenmenger W, Bondy B, Ackenheil M (2004b). Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. Eur Neuropsychopharmacol 14: 282-284.
46. Zill P, Buttner A, Eisenmenger W, Moller HJ, Ackenheil M, Bondy B (2007). Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: A post-mortem study. J Psychiatr Res 41: 168-173.
47. Zill P, Buttner A, Eisenmenger W, Moller HJ, Bondy B, Ackenheil M (2004c). Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 56: 581-586.