An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task

European Journal of Neuroscience

Volumn 22, Issue 4, 2005, Pages 997-1000

  Isles, Anthony R ^a,b   Hathway, Gareth J ^a,c   Humby, Trevor ^a   De La Riva, Carlos ^a   Kendrick, Keith M ^a   Wilkinson, Lawrence S ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Delayed gratification; Mice; Microdialysis; SNP; Tryptophan hydroxylase

Indexed keywords

NEUROTRANSMITTER; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN REGION; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; DECISION MAKING; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; IMPULSIVENESS; MALE; MICRODIALYSIS; MOUSE; MTPH2 GENE; NEUROBIOLOGY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REINFORCEMENT; SEROTONIN BRAIN LEVEL; SEROTONIN UPTAKE; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; EXTRACELLULAR SPACE; GENOTYPE; IMPULSIVE BEHAVIOR; MALE; MICE; MICE, TRANSGENIC; MICRODIALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; REINFORCEMENT (PSYCHOLOGY); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 24144434070     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04265.x     Document Type: Article

References (39)

1. Bizot, J., Le Bihan, C., Puech, A.J., Hamon, M. & Thiebot, M. (1999) Serotonin and tolerance to delay of reward in rats. Psychopharmacology (Berl), 146, 400-412.
2. Bizot, J.C., Thiebot, M.H., Le Bihan, C., Soubrie, P. & Simon, P. (1988) Effects of imipramine-like drugs and serotonin uptake blockers on delay of reward in rats. Possible implication in the behavioral mechanism of action of antidepressants. J. Pharmacol. Exp. Ther., 246, 1144-1151.
3. Bjork, J.M., Moeller, F.G., Dougherty, D.M., Swann, A.C., Machado, M.A. & Hanis, C.L. (2002) Serotonin 2a receptor T102C polymorphism and impaired impulse control. Am. J. Med. Genet., 114, 336-339.
4. Broad, K.D., Hinton, M.R., Keverne, E.B. & Kendrick, K.M. (2002) Involvement of the medial prefrontal cortex in mediating behavioural responses to odour cues rather than olfactory recognition memory. Neuroscience, 114, 715-729.
5. Brunner, D. & Hen, R. (1997) Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Ann. N.Y. Acad. Sci., 836, 81-105.
6. Cardinal, R.N., Pennicott, D.R., Sugathapala, C.L., Robbins, T.W. & Everitt, B.J. (2001) Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science, 292, 2499-2501.
7. Caspi, A., McClay, J., Moffitt, T.E., Mill, J., Martin, J., Craig, I.W., Taylor, A. & Poulton, R. (2002) Role of genotype in the cycle of violence in maltreated children. Science, 297, 851-854.
8. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. & Poulton, R. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
9. Chen, C.S., Burton, M., Greenberger, E. & Dmitrieva, J. (1999) Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe. Evol. Hum. Behav., 20, 309-324.
10. Crean, J., Richards, J.B. & de Wit, H. (2002) Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. Behav. Brain Res., 136, 349-357.
11. Dalley, J.W., Theobald, D.E., Eagle, D.M., Passetti, F. & Robbins, T.W. (2002) Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex. Neuropsychopharmacology, 26, 716-728.
12. Ding, Y.C., Chi, H.C., Grady, D.L., Morishima, A., Kidd, J.R., Kidd, K.K., Flodman, P., Spence, M.A., Schuck, S., Swanson, J.M., Zhang, Y.P. & Moyzis, R.K. (2002) Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc. Natl Acad. Sci. USA, 99, 309-314.
13. DSM-IV (1994) American Psychiatric Association Diagnostic and Statistical Manual IV. American Psychiatric Association, Washington DC.
14. Eagle, D.M. & Robbins, T.W. (2003) Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine. Behav. Neurosci., 117, 1302-1317.
15. Evenden, J. (1999a) Impulsivity: a discussion of clinical and experimental findings. J. Psychopharmacol., 13, 180-192.
16. Evenden, J.L. (1999b) Varieties of impulsivity. Psychopharmacology, 146, 348-361.
17. Fitzpatrick, P.F. (1999) Tetrahydropterin-dependent amino acid hydroxylases. Annu. Rev. Biochem., 68, 355-381.
18. Fletcher, P.J. (1995) Effects of combined or separate 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei on responding maintained by a DRL 20s schedule of food reinforcement. Brain Res., 675, 45-54.
19. Harrison, A.A., Everitt, B.J. & Robbins, T.W. (1997) Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berl), 133, 329-342.
20. Harrison, A.A., Everitt, B.J. & Robbins, T.W. (1999) Central serotonin depletion impairs both the acquisition and performance of a symmetrically reinforced go/no-go conditional visual discrimination. Behav. Brain Res., 100, 99-112.
21. Ho, M.Y., Mobini, S., Chiang, T.J., Bradshaw, C.M. & Szabadi, E. (1999) Theory and method in the quantitative analysis of 'impulsive choice' behaviour: implications for psychopharmacology. Psychopharmacology (Berl), 146, 362-372.
22. Isles, A.R., Humby, T., Walters, E. & Wilkinson, L.S. (2004) Common genetic effects on variation in impulsivity and activity in mice. J. Neurosci., 24, 6733-6740.
23. Isles, A.R., Humby, T. & Wilkinson, L.S. (2003) Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology (Berl), 170, 376-382.
24. Kendrick, K.M., Guevara-Guzman, R., de la Riva, C., Christensen, J., Ostergaard, K. & Emson, P.C. (1996) NMDA and kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role. Eur. J. Neurosci., 8, 2619-2634.
25. Liu, Y.P., Wilkinson, L.S. & Robbins, T.W. (2004) Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology (Berl), 173, 175-185.
26. Mobini, S., Chiang, T.J., Ho, M.Y., Bradshaw, C.M. & Szabadi, E. (2000) Effects of central 5-hydroxytryptamine depletion on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology (Berl), 152, 390-397.
27. New, A.S., Gelernter, J., Goodman, M., Mitropoulou, V., Koenigsberg, H., Silverman, J. & Siever, L.J. (2001) Suicide, impulsive aggression, and HTR1B genotype. Biol. Psychiatry, 50, 62-65.
28. Pattij, T., Broersen, L.M., van der Linde, J., Groenink, L., van der Gugten, J., Maes, R.A. & Olivier, B. (2003) Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout mice. Behav. Brain Res., 141, 137-145.
29. Paxinos, G. & Franklin, K.B.J. (2001) The Mouse Brain in Stereotaxic Coordinates. Academic Press, San Diego.
30. Rodriguez, M.L. & Logue, A.W. (1988) Adjusting delay to reinforcement: comparing choice in pigeons and humans. J. Exp. Psychol. Anim. Behav. Process, 14, 105-117.
31. Wade, T.R., de Wit, H. & Richards, J.B. (2000) Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology (Berl), 150, 90-101.
32. Winstanley, C.A., Chudasama, Y., Dalley, J.W., Theobald, D.E., Glennon, J.C. & Robbins, T.W. (2003) Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology (Berl), 167, 304-314.
33. Winstanley, C.A., Dalley, J.W., Theobald, D.E. & Robbins, T.W. (2004a) Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology, 29, 4712-4722.
34. Winstanley, C.A., Theobald, D.E., Dalley, J.W., Glennon, J.C. & Robbins, T.W. (2004b) 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology (Berl), 176, 376-385.
35. Wogar, M.A., Bradshaw, C.M. & Szabadi, E. (1993) Effect of lesions of the ascending 5-hydroxytryptaminergic pathways on choice between delayed reinforcers. Psychopharmacology (Berl), 111, 239-243.
36. Ye, S., Dhillon, S., Ke, X., Collins, A.R. & Day, I.N. (2001) An efficient procedure for genotyping single nucleotide polymorphisms. Nucl. Acids Res., 29, E88-E88.
37. Zhang, X., Beaulieu, J.M., Sotnikova, T.D., Gainetdinov, R.R. & Caron, M.G. (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science, 305, 217.
38. Zhang, H.Y., Ishigaki, T., Tani, K., Chen, K., Shih, J.C., Miyasato, K. & Ohara, K. (1997) Serotonin (2A) receptor gene polymorphism in mood disorders. Biol. Psychiatry, 41, 768-773.
39. Zill, P., Buttner, A., Eisenmenger, W., Moller, H.J., Bondy, B. & Ackenheil, M. (2004) Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry, 56, 581-586.