A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 5018-5024

  Schünemann, Katrin ^a   Connelly, Stephen ^b   Kowalczyk, Renata ^a   Sperry, Jonathan ^a   Wilson, Ian A ^b   Fraser, John D ^a   Brimble, Margaret A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Enzyme inhibitors; Human rhinovirus 3C protease; Protease activity; Thysanone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 6 CARBOXYFLUORESCEIN; HUMAN RHINOVIRUS 3C PROTEASE; HUMAN RHINOVIRUS 3C PROTEASE INHIBITOR; PROTEINASE; PROTEINASE INHIBITOR; THYSANONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG SCREENING; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HUMAN RHINOVIRUS; NONHUMAN; PEPTIDE ANALYSIS; PROTEINASE INHIBITION; SOLID;

CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ASSAYS; FLUORESCEINS; HUMANS; PEPTIDES; RHINOVIRUS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

HUMAN RHINOVIRUS 14; HUMAN RHINOVIRUS 3; HUMAN RHINOVIRUS SP.;

EID: 84863981409     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.015     Document Type: Article

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