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Volumn 13, Issue 20, 2003, Pages 3531-3536

Synthesis and evaluation of tripeptidyl α-ketoamides as human rhinovirus 3C protease inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KETOAMIDE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0141627972     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00753-4     Document Type: Article
Times cited : (26)

References (29)
  • 1
    • 0011123420 scopus 로고
    • Fields, B. N., Knipe, D. M., Eds.; Raven: New York
    • Couch, R. B. In Virology; Fields, B. N., Knipe, D. M., Eds.; Raven: New York, 1990.
    • (1990) Virology
    • Couch, R.B.1
  • 6
  • 7
    • 0034091629 scopus 로고    scopus 로고
    • Recent Reviews: (a) Dragovich P.S. Exp. Opin. Ther. Pat. 11:2001;177 (b) Wang Q.M. Drugs Future. 25:2000;279.
    • (2000) Drugs Future , vol.25 , pp. 279
    • Wang, Q.M.1
  • 18
    • 0000191714 scopus 로고
    • c.f. The enatiomerically pure material was obtained via chiral HPLC separation
    • c.f. Monn J.A., Valli M.J. J. Org. Chem. 59:1994;2773. The enatiomerically pure material was obtained via chiral HPLC separation.
    • (1994) J. Org. Chem. , vol.59 , pp. 2773
    • Monn, J.A.1    Valli, M.J.2
  • 25
    • 85031073445 scopus 로고    scopus 로고
    • P1-Nvaline bearing α-hydroxyacid was prepared from Z-Nva(H) via its corresponding cyanohydrin intermediate.
  • 26
    • 0014454095 scopus 로고    scopus 로고
    • i values were calculated according to the following reference: Morrison, J. F. Biochim. Biophys. Acta. 1969, 185, 269 for tight binding inhibitors. The Prism program (GraphPad Software) was used for this procedure.
  • 27
    • 85031073662 scopus 로고    scopus 로고
    • Cell-based antiviral assays were performed using confluent monolayers of HeLa cells infected with either HRV14 or HRV16 under the conditions described in the following reference: J. Med. Chem. 1999, 42, 50.
  • 28
    • 0025799991 scopus 로고
    • XTT cytotoxicity assay: HeLa cells were cultured under the identical conditions without virus infection but with the test compounds. Also see:
    • XTT cytotoxicity assay: HeLa cells were cultured under the identical conditions without virus infection but with the test compounds. Also see: Roehm N.W., Rodgers G.H., Hatfield S.M., Glasebrook A.L. J. Immunol. Methods. 142:1991;257.
    • (1991) J. Immunol. Methods , vol.142 , pp. 257
    • Roehm, N.W.1    Rodgers, G.H.2    Hatfield, S.M.3    Glasebrook, A.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.