Small molecule screening identifies regulators of the transcription factor ΔfosB

ACS Chemical Neuroscience

Volumn 3, Issue 7, 2012, Pages 546-556

  Wang, Yun ^a   Cesena, Teresa I ^a   Ohnishi, Yoko ^c   Burger Caplan, Rebecca ^c   Lam, Vivian ^a   Kirchhoff, Paul D ^b   Larsen, Scott D ^b   Larsen, Martha J ^c   Nestler, Eric J ^a   Rudenko, Gabby ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

FosB; depression; drug addiction; dyskinesia; high throughput screening; transcription factor

Indexed keywords

COCAINE; GLUTAMATE RECEPTOR 2; TRANSCRIPTION FACTOR DELTA FOSB;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; CORPUS STRIATUM; DYSKINESIA; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; INSECTS; MICE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; TRANSCRIPTION FACTORS;

MUS;

EID: 84863974456     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3000235     Document Type: Article

References (51)

1. Nestler, E. J. (2008) Review. Transcriptional mechanisms of addiction: role of DeltaFosB Philos. Trans. R. Soc., B 363, 3245-3255
2. Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., and Nestler, E. J. (2010) The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens Trends Neurosci. 33, 267-276
3. Berton, O., Guigoni, C., Li, Q., Bioulac, B. H., Aubert, I., Gross, C. E., Dileone, R. J., Nestler, E. J., and Bezard, E. (2009) Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease Biol. Psychiatry 66, 554-561
4. Cenci, M. A. and Konradi, C. (2010) Maladaptive striatal plasticity in L-DOPA-induced dyskinesia Prog. Brain Res. 183, 209-233
5. Cao, X., Yasuda, T., Uthayathas, S., Watts, R. L., Mouradian, M. M., Mochizuki, H., and Papa, S. M. (2010) Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements J. Neurosci. 30, 7335-7343
6. Vialou, V., Robison, A. J., Laplant, Q. C., Covington, H. E., 3rd, Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., 3rd, Watts, E. L., Wallace, D. L., Iniguez, S. D., Ohnishi, Y. H., Steiner, M. A., Warren, B. L., Krishnan, V., Bolanos, C. A., Neve, R. L., Ghose, S., Berton, O., Tamminga, C. A., and Nestler, E. J. (2010) DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses Nat. Neurosci. 13, 745-752
7. Ulery, P. G., Rudenko, G., and Nestler, E. J. (2006) Regulation of DeltaFosB stability by phosphorylation J. Neurosci. 26, 5131-5142
8. Linding, R., Jensen, L. J., Diella, F., Bork, P., Gibson, T. J., and Russell, R. B. (2003) Protein disorder prediction: implications for structural proteomics Structure 11, 1453-1459 (Pubitemid 37412427)
9. Robison, A. J. and Nestler, E. J. (2011) Transcriptional and epigenetic mechanisms of addiction Nat. Rev. Neurosci. 12, 623-637
10. Glover, J. N. and Harrison, S. C. (1995) Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA Nature 373, 257-261
11. Hess, J., Angel, P., and Schorpp-Kistner, M. (2004) AP-1 subunits: quarrel and harmony among siblings J. Cell Sci. 117, 5965-5973 (Pubitemid 40123963)
12. Andersson, M., Konradi, C., and Cenci, M. A. (2001) cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum J. Neurosci. 21, 9930-9943 (Pubitemid 34184077)
13. McClung, C. A. and Nestler, E. J. (2003) Regulation of gene expression and cocaine reward by CREB and DeltaFosB Nat. Neurosci. 6, 1208-1215 (Pubitemid 37346042)
14. Zachariou, V., Bolanos, C. A., Selley, D. E., Theobald, D., Cassidy, M. P., Kelz, M. B., Shaw-Lutchman, T., Berton, O., Sim-Selley, L. J., Dileone, R. J., Kumar, A., and Nestler, E. J. (2006) An essential role for DeltaFosB in the nucleus accumbens in morphine action Nat. Neurosci. 9, 205-211 (Pubitemid 43164543)
15. Valastro, B., Andersson, M., Lindgren, H. S., and Cenci, M. A. (2007) Expression pattern of JunD after acute or chronic L-DOPA treatment: comparison with deltaFosB Neuroscience 144, 198-207 (Pubitemid 44841995)
16. Jorissen, H. J., Ulery, P. G., Henry, L., Gourneni, S., Nestler, E. J., and Rudenko, G. (2007) Dimerization and DNA-binding properties of the transcription factor DeltaFosB Biochemistry 46, 8360-8372 (Pubitemid 47075973)
17. Vinson, C., Acharya, A., and Taparowsky, E. J. (2006) Deciphering B-ZIP transcription factor interactions in vitro and in vivo Biochim. Biophys. Acta 1759, 4-12
18. Ulery, P. G. and Nestler, E. J. (2007) Regulation of Delta FosB transcriptional activity by Ser27 phosphorylation Eur. J. Neurosci. 25, 224-230 (Pubitemid 46096236)
19. Brené, S., Messer, C., Okado, H., Hartley, M., Heinemann, S. F., and Nestler, E. J. (2000) Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element Eur. J. Neurosci. 12, 1525-1533 (Pubitemid 30258861)
20. Auld, D. S., Thorne, N., Nguyen, D. T., and Inglese, J. (2008) A specific mechanism for nonspecific activation in reporter-gene assays ACS Chem. Biol. 3, 463-470
21. Chinenov, Y. and Kerppola, T. K. (2001) Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity Oncogene 20, 2438-2452 (Pubitemid 32531301)
22. Fuxreiter, M., Tompa, P., Simon, I., Uversky, V. N., Hansen, J. C., and Asturias, F. J. (2008) Malleable machines take shape in eukaryotic transcriptional regulation Nat. Chem. Biol. 4, 728-737
23. Myers, S. J., Peters, J., Huang, Y., Comer, M. B., Barthel, F., and Dingledine, R. (1998) Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements J. Neurosci. 18, 6723-6739 (Pubitemid 28388004)
24. Qiu, Z., Sylwestrak, E. L., Lieberman, D. N., Zhang, Y., Liu, X. Y., and Ghosh, A. (2012) The Rett Syndrome protein MeCP2 regulates synaptic scaling J. Neurosci. 32, 989-994
25. Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., and Lee, C. M. (2011) Translating glutamate: from pathophysiology to treatment Sci. Transl. Med. 3, 102mr2
26. Bowers, M. S., Chen, B. T., and Bonci, A. (2010) AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future Neuron 67, 11-24
27. Sanacora, G., Zarate, C. A., Krystal, J. H., and Manji, H. K. (2008) Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders Nat. Rev. Drug Discovery 7, 426-437 (Pubitemid 351619114)
28. Tokita, K., Yamaji, T., and Hashimoto, K. (2012) Roles of glutamate signaling in preclinical and/or mechanistic models of depression Pharmacol., Biochem. Behav. 100, 688-704
29. Lipinski, C. A., Lombardo, F., Dominy, B. W., and Feeney, P. J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 46, 3-26 (Pubitemid 33653411)
30. Berg, T. (2008) Inhibition of transcription factors with small organic molecules Curr. Opin. Chem. Biol. 12, 464-471
31. Koehler, A. N. (2010) A complex task? Direct modulation of transcription factors with small molecules Curr. Opin. Chem. Biol. 14, 331-340
32. Wells, J. A. and McClendon, C. L. (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 450, 1001-1009 (Pubitemid 350273630)
33. Cheng, Y., LeGall, T., Oldfield, C. J., Mueller, J. P., Van, Y. Y., Romero, P., Cortese, M. S., Uversky, V. N., and Dunker, A. K. (2006) Rational drug design via intrinsically disordered protein Trends Biotechnol. 24, 435-442 (Pubitemid 44374778)
34. Metallo, S. J. (2010) Intrinsically disordered proteins are potential drug targets Curr. Opin. Chem. Biol. 14, 481-488
35. Park, C. H., Lee, J. H., and Yang, C. H. (2005) Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues J. Biochem. Mol. Biol. 38, 474-480
36. Park, S., Song, J. S., Lee, D. K., and Yang, C. H. (1999) Suppression of AP-1 activity by tanshinone and cancer cell growth inhibition Bull. Korean Chem. Soc. 20, 925-928
37. Park, S., Lee, D. K., and Yang, C. H. (1998) Inhibition of fos-jun-DNA complex formation by dihydroguaiaretic acid and in vitro cytotoxic effects on cancer cells Cancer Lett. 127, 23-28 (Pubitemid 28230781)
38. Aikawa, Y., Morimoto, K., Yamamoto, T., Chaki, H., Hashiramoto, A., Narita, H., Hirono, S., and Shiozawa, S. (2008) Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1 Nat. Biotechnol. 26, 817-823 (Pubitemid 351961451)
39. Rishi, V., Potter, T., Laudeman, J., Reinhart, R., Silvers, T., Selby, M., Stevenson, T., Krosky, P., Stephen, A. G., Acharya, A., Moll, J., Oh, W. J., Scudiero, D., Shoemaker, R. H., and Vinson, C. (2005) A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors Anal. Biochem. 340, 259-271 (Pubitemid 40544865)
40. Rishi, V., Oh, W. J., Heyerdahl, S. L., Zhao, J., Scudiero, D., Shoemaker, R. H., and Vinson, C. (2010) 12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers J. Struct. Biol. 170, 216-225
41. Yin, X., Giap, C., Lazo, J. S., and Prochownik, E. V. (2003) Low molecular weight inhibitors of Myc-Max interaction and function Oncogene 22, 6151-6159 (Pubitemid 37281644)
42. Follis, A. V., Hammoudeh, D. I., Wang, H., Prochownik, E. V., and Metallo, S. J. (2008) Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules Chem. Biol. 15, 1149-1155
43. Hammoudeh, D. I., Follis, A. V., Prochownik, E. V., and Metallo, S. J. (2009) Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc J. Am. Chem. Soc. 131, 7390-7401
44. Kiessling, A., Sperl, B., Hollis, A., Eick, D., and Berg, T. (2006) Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules Chem. Biol. 13, 745-751 (Pubitemid 44093290)
45. Kiessling, A., Wiesinger, R., Sperl, B., and Berg, T. (2007) Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine ChemMedChem 2, 627-630
46. Peakman, M. C., Colby, C., Perrotti, L. I., Tekumalla, P., Carle, T., Ulery, P., Chao, J., Duman, C., Steffen, C., Monteggia, L., Allen, M. R., Stock, J. L., Duman, R. S., McNeish, J. D., Barrot, M., Self, D. W., Nestler, E. J., and Schaeffer, E. (2003) Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine Brain Res. 970, 73-86 (Pubitemid 36423183)
47. Andersson, M., Westin, J. E., and Cenci, M. A. (2003) Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment Eur. J. Neurosci. 17, 661-666 (Pubitemid 36255903)
48. Baell, J. B. and Holloway, G. A. (2010) New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays J. Med. Chem. 53, 2719-2740
49. Mendgen, T., Steuer, C., and Klein, C. D. (2012) Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry J. Med. Chem. 55, 743-753
50. Whitmore, L. and Wallace, B. A. (2004) DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data Nucleic Acids Res. 32, W668-673
51. Whitmore, L. and Wallace, B. A. (2008) Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases Biopolymers 89, 392-400