Dimerization and DNA-binding properties of the transcription factor ΔFosB

Biochemistry

Volumn 46, Issue 28, 2007, Pages 8360-8372

  Jorissen, Helena J M M ^a   Ulery, Paula G ^b   Henry, Lisa ^c   Gourneni, Sreekrishna ^a   Nestler, Eric J ^b   Rudenko, Gabby ^a,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC STIMULATION; HOMODIMERS; NEUROLOGIC DISORDERS; TRANSCRIPTION FACTOR;

BRAIN; DIMERIZATION; DNA; GENE EXPRESSION; OLIGONUCLEOTIDES; PROTEINS;

BIOCHEMISTRY;

ANTIDEPRESSANT AGENT; ISOPROTEIN; NEUROLEPTIC AGENT; TRANSCRIPTION FACTOR FOSB;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONSENSUS; DIMERIZATION; DNA BINDING; DRUG ABUSE; ELECTROCONVULSIVE THERAPY; GENE EXPRESSION REGULATION; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; CHROMATOGRAPHY, GEL; DIMERIZATION; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENCE POLARIZATION; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; ULTRACENTRIFUGATION;

ANIMALIA; RODENTIA;

EID: 34447534398     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700494v     Document Type: Article

References (64)

1. Morgan, J. I., and Curran, T. (1995) Immediate-early genes: Ten years on, Trends Neurosci. 18, 66-67.
2. Rylski, M., and Kaczmarek, L. (2004) Ap-1 targets in the brain, Front. Biosci. 9, 8-23.
3. Nestler, E. J., Barret, M., and Self, D. W. (2001) ΔFosB: A sustained molecular switch for addiction, Proc. Natl. Acad. Sci. U.S.A. 98, 11042-11046.
4. McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., and Nestler, E. J. (2004) ΔFosB: A molecular switch for long-term adaptation in the brain, Brain Res. Mol. Brain Res. 132, 146-154.
5. Ulery, P. G., Rudenko, G., and Nestler, E. J. (2006) Regulation of ΔFosB stability by phosphorylation, J. Neurosci. 26, 5131-5142.
6. Alibhai, I. N., Green, T. A., and Nestler, E. J. (2007) Regulation of fosB and ΔfosB mRNA expression: In vivo and in vitro studies, Brain Res., in press.
7. Carle, T. L., Alibhai, I. N., Wilkinson, M. B., Kumar, A., and Nestler, E. J. (2007) Proteasome dependent and independent mechanisms for FosB destabilization: Identification of FosB degradation domains and implications for ΔFosB stability, Eur. J. Neurosci., manuscript in revision.
8. Kumar, A., Choi, K. H., Renthal, W., Tsankova, N. M., Theobald, D. E., Truong, H. T., Russo, S. J., Laplant, Q., Sasaki, T. S., Whistler, K. N., Neve, R. L., Self, D. W., and Nestler, E. J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum, Neuron 48, 303-314.
9. McClung, C. A., and Nestler, E. J. (2003) Regulation of gene expression and cocaine reward by CREB and ΔFosB, Nat. Neurosci. 6, 1208-1215.
10. Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., and Gray, T. (1995) How to measure and predict the molar absorption coefficient of a protein, Protein Sci. 4, 2411-2423.
11. Laue, T. M., Shah, B. D., Ridgeway, T. M., and Pelletier, S. L. (1992) Computer-aided interpretation of sedimentation data for proteins, in Analytical Ultracentrifugation in Biochemistry and Polymer Science (Harding, S. E., Rowe, A. J., and Horton, J. C., Eds.) pp 90-125, The Royal Society of Chemistry, Cambridge, U.K.
12. Stafford, W. F., Walker, M. L., Trinick, J. A., and Coluccio, L. M. (2005) Mammalian class I myosin, Myolb, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy, Biophys. J. 88, 384-391.
13. Schuck, P. (2000) Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling, Biophys. J. 78, 1606-1619.
14. Schuck, P. (2005) In Modern Analytical Ultracentrifugation: Techniques and Methods (Scott, D. J., Harding, S. E., and Rowe, A. J., Eds.) The Royal Society of Chemistry, Cambridge, U.K.
15. Vistica, J., Dam, J., Balbo, A., Yikilmaz, E., Mariuzza, R. A., Rouault, T. A., and Schuck, P. (2004) Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition, Anal. Biochem. 326, 234-256.
16. Hu, C. C., and Ghabrial, S. A. (1995) The conserved, hydrophilic and arginine-rich N-terminal domain of cucumovirus coat proteins contributes to their anomalous electrophoretic mobilities in sodium dodecylsulfate- polyacrylamide gels, J. Virol. Methods 55, 367-379.
17. Graceffa, P., Jancsó, A., and Mabuchi, K. (1992) Modification of acidic residues normalizes sodium dodecyl sulfate-polyacrylamide gel electrophoresis of caldesmon and other proteins that migrate anomalously, Arch. Biochem. Biophys. 297, 46-51.
18. Chen, J., Kelz, M. B., Hope, B. T., Nakabeppu, Y., and Nestler, E. J. (1997) Chronic Fos-related antigens: Stable variants of ΔFosB induced in brain by chronic treatments, J. Neurosci. 17, 4933-4941.
19. Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., and Nestler, E. J. (2000) Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: Role of ΔFosB, J. Neurosci. 20, 8965-8971.
20. Kelz, M. B., Chen, J., Carlezon, W. A., Jr., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y. J., Marotti, L., Self, D. W., Tkatch, T., Baranauskas, G., Surmeier, D. J., Neve, R. L., Duman, R. S., Picciotto, M. R., and Nestler, E. J. (1999) Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine, Nature 401, 272-276.
21. Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., and Nestler, E. J. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments, Neuron 13, 1235-1244.
22. Couceyro, P., Pollock, K. M., Drews, K., and Douglass, J. (1994) Cocaine differentially regulates activator protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum, Mol. Pharmacol. 46, 667-676.
23. Chen, J., Nye, H. E., Kelz, M. B., Hiroi, N., Nakabeppu, Y., Hope, B. T., and Nestler, E. J. (1995) Regulation of ΔFosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments, Mol. Pharmacol. 48, 880-889.
24. Moratalla, R., Elibol, B., Vallejo, M., and Graybiel, A. M. (1996) Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal, Neuron 17, 147-156.
25. Nye, H. E., and Nestler, E. J. (1996) Induction of chronic Fos-related antigens in rat brain by chronic morphine administration, Mol. Pharmacol. 49, 636-645.
26. Muller, D. L., and Unterwald, E. M. (2005) D1 dopamine receptors modulate ΔFosB induction in rat striatum after intermittent morphine administration, J. Pharmacol. Exp. Ther. 314, 148-154.
27. McDaid, J., Dallimore, J. E., Mackie, A. R., and Napier, T. C. (2006) Changes in accumbal and pallidal pCREB and ΔFosB in morphine-sensitized rats: Correlations with receptor-evoked electrophysiological measures in the ventral pallidum, Neuropsychopharmacology 31, 1212-1226.
28. Radwanska, K., Valjent, E., Trzaskos, J., Caboche, J., and Kaczmarek, L. (2006) Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway, Neuroscience 137, 253-264.
29. Hope, B. T., Kelz, M. B., Duman, R. S., and Nestler, E. J. (1994) Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics, J. Neurosci. 14, 4318-4328.
30. Mandelzys, A., Gruda, M. A., Bravo, R., and Morgan, J. I. (1997) Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice, J. Neurosci. 17, 5407-5415.
31. Hiroi, N., Marek, G. J., Brown, J. R., Ye, H., Saudou, F., Vaidya, V. A., Duman, R. S., Greenberg, M. E., and Nestler, E. J. (1998) Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures, J. Neurosci. 18, 6952-6962.
32. Morris, T. A., Jafari, N., and DeLorenzo, R. J. (2000) Chronic ΔFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy, Brain Res. Mol. Brain Res. 79, 138-149.
33. Vallone, D., Pellecchia, M. T., Morelli, M., Verde, P., DiChiara, G., and Barone, P. (1997) Behavioural sensitization in 6-hydroxydopamine-lesioned rats is related to compositional changes of the AP-1 transcription factor: Evidence for induction of FosB- and JunD-related proteins, Brain Res. Mol. Brain Res. 52, 307-317.
34. Hiroi, N., and Graybiel, A. M. (1996) Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum, J. Comp. Neurol. 374, 70-83.
35. Atkins, J. B., Chlan-Fourney, J., Nye, H. E., Hiroi, N., Carlezon, W. A., Jr., and Nestler, E. J. (1999) Region-specific induction of ΔFosB by repeated administration of typical versus atypical antipsychotic drugs, Synapse 33, 118-128.
36. Kontkanen, O., Lakso, M., Wong, G., and Castren, E. (2002) Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex, Neuropsychopharmacology 27, 152-162.
37. Bing, G., Wang, W., Qi, Q., Feng, Z., Hudson, P., Jin, L., Zhang, W., Bing, R., and Hong, J. S. (1997) Long-term expression of Fos-related antigen and transient expression of ΔFosB associated with seizures in the rat hippocampus and striatum, J. Neurochem. 68, 272-279.
38. Perez-Otano, I., Mandelzys, A., and Morgan, J. I. (1998) MPTP-Parkinsonism is accompanied by persistent expression of a ΔFosB-like protein in dopaminergic pathways, Brain Res. Mol. Brain Res. 53, 41-52.
39. Andersson, M., Westin, J. E., and Cenci, M. A. (2003) Time course of striatal ΔFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment, Eur. J. Neurosci. 17, 661-666.
40. Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L., Duman, R. S., and Nestler, E. J. (2004) Induction of ΔFosB in reward-related brain structures after chronic stress, J. Neurosci. 24, 10594-10602.
41. Colby, C. R., Whisler, K., Steffen, C., Nestler, E. J., and Self, D. W. (2003) Striatal cell type-specific overexpression of ΔFosB enhances incentive for cocaine, J. Neurosci. 23, 2488-2493.
42. Peakman, M. C., Colby, C., Perrotti, L. I., Tekumalla, P., Carle, T., Ulery, P., Chao, J., Duman, C., Steffen, C., Monteggia, L., Allen, M. R., Stock, J. L., Duman, R. S., McNeish, J. D., Barrot, M., Self, D. W., Nestler, E. J., and Schaeffer, E. (2003) Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine, Brain Res. 970, 73-86.
43. Zachariou, V., Bolanos, C. A., Selley, D. E., Theobald, D., Cassidy, M. P., Kelz, M. B., Shaw-Lutchman, T., Berton, O., Sim-Selley, L. J., Dileone, R. J., Kumar, A., and Nestler, E. J. (2006) An essential role for ΔFosB in the nucleus accumbens in morphine action, Nat. Neurosci. 9, 205-211.
44. Andersson, M., Hilbertson, A., and Cenci, M. A. (1999) Striatal fosB expression is causally linked with L-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease, Neurobiol. Dis. 6, 461-474.
45. Cenci, M. A., Tranberg, A., Andersson, M., and Hilbertson, A. (1999) Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-DOPA treatment, Neuroscience 94, 515-527.
46. Andersson, M., Konradi, C., and Cenci, M. A. (2001) cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum, J. Neurosci. 21, 9930-9943.
47. Cenci, M. A. (2002) Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease, Amino Acids 23, 105-109.
48. Carlsson, T., Winkler, C., Burger, C., Muzyczka, N., Mandel, R. J., Cenci, A., Bjorklund, A., and Kirik, D. (2005) Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors, Brain 128, 559-569.
49. Berton, O., Tsankova, N. M., Carle, T. L., Ulery, P. G., Bhonsle, A., Barrot, M., Neve, R. L., and Nestler, E. J. (2007) Induction of ΔFosB in the periaqueductal gray by stress promotes active coping responses, Neuron, manuscript in revision.
50. Ulery, P. G., and Nestler, E. J. (2007) Regulation of ΔFosB transcriptional activity by Ser27 phosphorylation, Eur. J. Neurosci. 25, 224-230.
51. Nakabeppu, Y., and Nathans, D. (1991) A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity, Cell 64, 751-759.
52. Yen, J., Wisdom, R. M., Tratner, I., and Verma, I. M. (1991) An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins, Proc. Natl. Acad. Sci. U.S.A. 88, 5077-5081.
53. Dobrazanski, P., Noguchi, T., Kovary, K., Rizzo, C. A., Lazo, P. S., and Bravo, R. (1991) Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts, Mol. Cell. Biol. 11, 5470-5478.
54. Wisdom, R., and Verma, I. M. (1993) Proto-oncogene FosB: The amino terminus encodes a regulatory function required for transformation, Mol. Cell. Biol. 13, 2635-2643.
55. Chinenov, Y., and Kerppola, T. K. (2001) Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity, Oncogene 20, 2438-2452.
56. Hess, J., Angel, P., and Schorpp-Kistner, M. (2004) AP-1 subunits: Quarrel and harmony among siblings, J. Cell Sci. 117, 5965-5973.
57. Hiroi, N., Brown, J. R., Haile, C. N., Ye, H., Greenberg, M. E., and Nestler, E. J. (1997) FosB mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects, Proc. Natl. Acad. Sci. U.S.A. 94, 10397-10402.
58. Winston, S. M., Hayward, M. D., Nestler, E. J., and Duman, R. S. (1990) Chronic electroconvulsive seizures down-regulate expression of the immediate-early genes c-fos and c-jun in rat cerebral cortex, J. Neurochem. 54, 1920-1925.
59. Hope, B., Kosofsky, B., Hyman, S. E., and Nestler, E. J. (1992) Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine, Proc. Natl. Acad. Sci. U.S.A. 89, 5764-5768.
60. Valastro, B., Andersson, M., Lindgren, H. S., and Cenci, M. A. (2007) Expression pattern of JunD after acute or chronic 1-DOPA treatment: Comparison with ΔFosB, Neuroscience 144, 198-207.
61. O'Shea, E. K., Rutkowski, R., Stafford, W. F., III, and Kim, P. S. (1989) Preferential heterodimer formation by isolated leucine zippers from fos and jun, Science 245, 646-648.
62. Vinson, C., Myakishev, M., Acharya, A., Mir, A. A., Moll, J. R., and Bonovich, M. (2002) Classification of human B-ZIP proteins based on dimerization properties, Mol. Cell. Biol. 22, 6321-6335.
63. Nakabeppu, Y., Ryder, K., and Nathans, D. (1988) DNA binding activities of three murine Jun proteins: Stimulation by Fos, Cell 55, 907-915.
64. Ryseck, R. P., and Bravo, R. (1991) c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: Effect of FOS proteins, Oncogene 6, 533-542.