Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11300-11305

  Qian, Yingjuan ^a   Jung, Yong Sam ^a   Chen, Xinbin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Growth differentiation factor 15; Stimulated by retinoic acid 13

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DIFFERENTIATED EMBRYO CHONDROCYTE EXPRESSED GENE 1; GROWTH DIFFERENTIATION FACTOR 15; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL SURVIVAL; DNA BINDING; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE CONTROL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING;

APOPTOSIS; CELL AGING; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; DNA DAMAGE; GENES, P53; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; PROMOTER REGIONS, GENETIC; TRETINOIN; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84863949519     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203185109     Document Type: Article

References (45)

1. Beckerman R, Prives C (2010) Transcriptional regulation by p53. Cold Spring Harb Perspect Biol 2:a000935.
2. Harms K, Nozell S, Chen X (2004) The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61:822-842. (Pubitemid 38651002)
3. Liu G, Chen X (2006) DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol Cell Biol 26:1398-1413. (Pubitemid 43202565)
4. Chen X, Ko LJ, Jayaraman L, Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10: 2438-2451. (Pubitemid 26341879)
5. Walker KK, Levine AJ (1996) Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93:15335-15340. (Pubitemid 27009601)
6. Zhu J, Jiang J, Zhou W, Zhu K, Chen X (1999) Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity. Oncogene 18:2149-2155. (Pubitemid 29178584)
7. Zhu J, Zhang S, Jiang J, Chen X (2000) Definition of the p53 functional domains necessary for inducing apoptosis. J Biol Chem 275:39927-39934. (Pubitemid 32064614)
8. Samuels-Lev Y, et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8:781-794. (Pubitemid 33030212)
9. Bourdon JC, et al. (2005) p53 isoforms can regulate p53 transcriptional activity. Genes Dev 19:2122-2137.
10. Dai C, et al. (2011) Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci USA 108:18937-18942.
11. MacLachlan TK, Takimoto R, El-Deiry WS (2002) BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol Cell Biol 22:4280-4292. (Pubitemid 34556596)
12. Das S, et al. (2007) Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 130:624-637. (Pubitemid 47277418)
13. Tanaka T, Ohkubo S, Tatsuno I, Prives C (2007) hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130:638-650. (Pubitemid 47268061)
14. Honma S, et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419:841-844. (Pubitemid 35238570)
15. Collado M, et al. (2005) Tumour biology: Senescence in premalignant tumours. Nature 436:642. (Pubitemid 41117258)
16. Qian Y, Zhang J, Yan B, Chen X (2008) DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283:2896-2905.
17. Qian Y, Chen X (2008) ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. J Biol Chem 283:22410-22416.
18. Li Y, et al. (2002) Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: Its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem J 367:413-422. (Pubitemid 35216815)
19. Ehata S, et al. (2007) Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res 67:9694-9703. (Pubitemid 47621216)
20. Thin TH, Li L, Chung TK, Sun H, Taneja R (2007) Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. EMBO Rep 8:401-407. (Pubitemid 46511042)
21. Bootcov MR, et al. (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA 94: 11514-11519. (Pubitemid 27451030)
22. Böttner M, Suter-Crazzolara C, Schober A, Unsicker K (1999) Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophageinhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res 297:103-110. (Pubitemid 29313281)
23. Baek SJ, Horowitz JM, Eling TE (2001) Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3. J Biol Chem 276:33384-33392.
24. Paralkar VM, et al. (1998) Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem 273:13760-13767. (Pubitemid 28268424)
25. Tan M, Wang Y, Guan K, Sun Y (2000) PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci USA 97:109-114. (Pubitemid 30055792)
26. Hromas R, et al. (1997) PLAB, a novel placental bone morphogenetic protein. Biochim Biophys Acta 1354:40-44. (Pubitemid 27479891)
27. Li PX, et al. (2000) Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J Biol Chem 275:20127-20135.
28. Dai MS, et al. (2004) Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol 24:7654-7668.
29. Li Y, et al. (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem 278:16899-16907. (Pubitemid 36799562)
30. Qian Y, Jung YS, Chen X (2011) DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem 286:12033-12041.
31. Harms KL, Chen X (2007) Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res 67:3145-3152. (Pubitemid 46724851)
32. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
33. Thornborrow EC, Patel S, Mastropietro AE, Schwartzfarb EM, Manfredi JJ (2002) A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes. Oncogene 21:990-999. (Pubitemid 34174511)
34. Friedman PN, Chen X, Bargonetti J, Prives C (1993) The p53 protein is an unusually shaped tetramer that binds directly to DNA. Proc Natl Acad Sci USA 90:3319-3323. (Pubitemid 23111357)
35. Pietsch EC, et al. (2007) The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biol Ther 6:1576-1583. (Pubitemid 351590329)
36. Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14:289-300. (Pubitemid 30106484)
37. Yakovlev AG, et al. (2004) BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem 279:28367-28374. (Pubitemid 38900116)
38. Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694. (Pubitemid 32706359)
39. Bansal N, et al. (2011) Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PLoS ONE 6:e26156.
40. Ito A, et al. (2002) MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J 21:6236-6245. (Pubitemid 35415340)
41. Welsh JB, et al. (2003) Large-scale delineation of secreted protein biomarkers over-expressed in cancer tissue and serum. Proc Natl Acad Sci USA 100:3410-3415. (Pubitemid 36356597)
42. Gery S, et al. (2006) The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 22:375-382.
43. Fu L, Pelicano H, Liu J, Huang P, Lee C (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41-50.
44. Lee JH, Sancar A (2011) Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proc Natl Acad Sci USA 108:10668-10672.
45. Bjarnason GA, et al. (2001) Circadian expression of clock genes in human oral mucosa and skin: Association with specific cell-cycle phases. Am J Pathol 158:1793-1801. (Pubitemid 32422944)