Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Bansal, Nidhi ^a   Kadamb, Rama ^a   Mittal, Shilpi ^a   Vig, Leena ^a   Sharma, Raisha ^a   Dwarakanath, Bilikere S ^b   Saluja, Daman ^a  

^a UNIVERSITY OF DELHI   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; HISTONE DEACETYLASE 1; PROTEIN P53; REGULATOR PROTEIN; SIN3B PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DOXORUBICIN; HDAC1 PROTEIN, HUMAN; HEAT SHOCK COGNATE PROTEIN 70; HISTONE; HSPA8 PROTEIN, HUMAN; LYSINE; MAD1L1 PROTEIN, HUMAN; NUCLEAR PROTEIN; REPRESSOR PROTEIN; SIN3B PROTEIN, HUMAN; ZETA CRYSTALLIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL STRESS; CHROMATIN ASSEMBLY AND DISASSEMBLY; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EPIGENETICS; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE TARGETING; GENETIC CODE; GENETIC CONSERVATION; GENOTOXICITY; HEAT SHOCK PROTEIN 71 GENE; HISTONE METHYLATION; HUMAN; HUMAN CELL; MITOTIC ARREST DEFICIENT LIKE 1 GENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; ZETA CRYSTALLIN GENE; ANIMAL; CHEMISTRY; DNA DAMAGE; DRUG EFFECT; GENE SILENCING; GENETICS; METABOLISM; METHYLATION; MOUSE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DOWN-REGULATION; DOXORUBICIN; GENE SILENCING; HISTONE DEACETYLASE 1; HISTONES; HSC70 HEAT-SHOCK PROTEINS; HUMANS; LYSINE; METHYLATION; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; ZETA-CRYSTALLINS;

EID: 80054792942     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026156     Document Type: Article

References (49)

1. Funk WD, Pak DJ, Karas RH, Wright WE, Shay JW, (1992) A transcriptionally active DNA binding site for human p53 protein complexes. Mol Cell Biol 12: 2866-2871.
2. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B, (1992) Definition of a consensus binding site for p53. Nat Genet 1: 45-49.
3. Mirza A, Wu Q, Wang L, McClanahan T, Bishop WR, et al. (2003) Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression. Oncogene 22: 3645-3654.
4. Laptenko O, Prives C, (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 13: 951-961.
5. Riley T, Sontag E, Chen P, Levine A, (2008) Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9: 402-412.
6. Murphy M, Ahn J, Walker KK, Hoffman WH, Evans RM, et al. (1999) Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes dev 13: 2490-2501.
7. Chun ACS, Jin DY, (2003) Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. J Biol Chem 278: 37439-37450.
8. Zhang Y, Wang JS, Chen LL, Zhang Y, Cheng XK, et al. (2004) Repression of hsp90â gene by p53 in UV irradiation-induced apoptosis of Jurkat cells. Biol Chem 279: 42545-42551.
9. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 7: 165-171.
10. Ayer DE, Lawrence QA, Eisenman RN, (1995) Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80: 767-776.
11. Grzenda A, Lomberk G, Zhang JS, Urrutia R, (2009) Sin3: Master scaffold and transcriptional corepressor. Biochim Biophys Acta 1789: 443-445.
12. Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, et al. (2003) An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem 369: 651-657.
13. Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, et al. (1997) Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase. Cell 89: 373-380.
14. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389.
15. Xu Y, Harton JA, Smith BD, (2008) CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. Biol Chem 283: 1243-1256.
16. Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, et al. (2002) E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev 16: 933-947.
17. Grandinetti KB, David G, (2008) Sin3B: an essential regulator of chromatin modifications at E2F target promoters during cell cycle withdrawal. Cell Cycle 7: 1550-1554.
18. Koipally J, Renold A, Kim J, Georgopoulos K, (1999) Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 18: 3090-3100.
19. Romm E, Nielsen JA, Kim JG, Hudson LD, (2005) Myt1 family recruits histone deacetylase to regulate neural transcription. J Neurochem 93: 1444-1453.
20. Zilfou JT, Hoffman WH, Sank M, George DL, Murphy M, (2001) The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation. Mol Cell Biol 2: 3974-3985.
21. Grandinetti KB, Jelinic P, DiMauro T, Pellegrino J, Rodri{dotless}'guez RF, et al. (2009) Sin3B Expression is Required for Cellular Senescence and Is Up-regulated upon Oncogenic Stress. Cancer Res 69: 6430-6437.
22. Osheroff N, Corbett A, Robinson M, (1994) Mechanism of action of topoisomerase II-targeted antineoplastic drugs. Adv Pharmacol 29B: 105-126.
23. Prives C, (1998) Signaling to p53: breaking the MDM2-p53 circuit. Cell 95: 5-8.
24. Lee TK, Lau TC, Ng IO, (2002) Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines. Cancer Chemother Pharmacol 49: 78-86.
25. Barranco SC, Gerner EW, Burk KH, Humphrey RM, (1973) Survival and cell kinetics effects of Adriamycin on mammalian cells. Cancer Res 33: 11-16.
26. Siu WY, Yam CH, Poon RYC, (1999) G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swisss3T3 cells. FEBS Lett 461: 299-305.
27. Giacci AJ, Kastan MB, (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12: 2973-2983.
28. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T, (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410: 116-120.
29. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, et al. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410: 120-124.
30. Yamane K, Toumazou C, Tsukada YI, Erdjument-Bromage H, Tempst P, et al. (2006) JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 125: 483-495.
31. Lee KC, Crowe AJ, Barton MC, (1999) p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol Cell Biol 19: 1279-1288.
32. Im H-J, Pittelkow MR, Kumar R, (2002) Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. J Biol Chem 277: 14612-14621.
33. Walker KK, Levine AJ, (1996) Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93: 15335-15340.
34. Sakamuro D, Sabbatini P, White E, Prendergast GC, (1997) The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15: 887-898.
35. Venot C, Maratrat M, Dureuil C, Conseiller E, Bracco L, et al. (1998) The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. J EMBO 17: 4668-4679.
36. Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, et al. (2001) Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 21: 1297-310.
37. Crosby ME, Oancea M, Almasan A, (2004) p53 binding to target sites is dynamically regulated before and after ionizing radiation-mediated DNA damage. J Environ Pathol Toxicol Oncol 23: 67-79.
38. Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, et al. (2005) Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters. Mol Cell Biol 25: 3737-3751.
39. Ceribelli M, Alcalay M, Viganò MA, Mantovani R, (2006) Repression of New p53 Targets Revealed by ChIP on Chip Experiments. Cell Cycle 5: 1102-1110.
40. Akakura S, Yoshida M, Yoneda Y, Horinouchi S, (2001) A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135). J Biol Chem 276: 14649-14657.
41. Lapucci A, Lulli M, Amedei A, Papucci L, Witort E, et al. (2010) ζ-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. FASEB J 24: 1852-1865.
42. Wu Y, Mehew JW, Heckman CA, Arcinas M, Boxer LM, (2001) Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene 20: 240-251.
43. Ryan KM, Vousden KH, (1998) Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. Mol Cell Biol 18: 3692-3698.
44. Klose RJ, Zhang Y, (2007) Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol 8: 307-318.
45. Nguyen TT, Cho K, Stratton SA, Barton MC, (2005) Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol 25: 2147-2157.
46. Fischle W, Wang Y, Allis CD, (2003) Histone and chromatin cross-talk. Curr Opin Cell Biol 15: 172-183.
47. Fuks F, Hurd PJ, Wolf D, Nan X, Bird AP, et al. (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278: 4035-4040.
48. Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, et al. (2006) Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125: 467-481.
49. Soutoglou E, Talianidis I, (2002) Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science 295: 1901-1904.