메뉴 건너뛰기




Volumn 31, Issue 1, 2012, Pages 21-32

Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function

Author keywords

Alzheimer's disease; amyloid ; A PP mutation; Dimebon; latrepirdine; mitochondrial dynamics; mitochondrial dysfunction; mitochondrial mass; mitochondrial morphology; mitochondrial respiratory complexes; OXPHOS

Indexed keywords

AMYLOID BETA PROTEIN; DIMEBON;

EID: 84863944817     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120310     Document Type: Article
Times cited : (40)

References (67)
  • 1
    • 77955089623 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: Common final pathway in brain aging and alzheimer's disease-therapeutic aspects
    • Muller WE, Eckert A, Kurz C, Eckert GP, Leuner K (2010) Mitochondrial dysfunction: Common final pathway in brain aging and Alzheimer's disease-therapeutic aspects. Mol Neu-robiol 41, 159-171.
    • (2010) Mol Neu-robiol , vol.41 , pp. 159-171
    • Muller, W.E.1    Eckert, A.2    Kurz, C.3    Eckert, G.P.4    Leuner, K.5
  • 3
    • 79952857922 scopus 로고    scopus 로고
    • Mitochondrial fission and fusion machineries
    • Koehler C, Bauer MF, eds. Springer, Inc., Heidelberg
    • Griparic L, Head B, van der Bliek AM (2004) Mitochondrial fission and fusion machineries, In: Mitochondrial Function and Biogenetics, Koehler C, Bauer MF, Eds. Springer Inc., Heidelberg, p. 227.
    • (2004) Mitochondrial Function and Biogenetics , pp. 227
    • Griparic, L.1    Head, B.2    Van Der Bliek, A.M.3
  • 5
    • 51749084230 scopus 로고    scopus 로고
    • Ultrastructureof the mitochondrion and its bearing on function and bioenergetics
    • Benard G, Rossignol R (2008) Ultrastructureof the mitochondrion and its bearing on function and bioenergetics. Antioxid Redox Signal 10, 1313-1342.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1313-1342
    • Benard, G.1    Rossignol, R.2
  • 7
    • 40849092781 scopus 로고    scopus 로고
    • Mitochondrial energetics and insulin resistance
    • Civitarese AE, Ravussin E (2008) Mitochondrial energetics and insulin resistance. Endocrinology 149, 950-954.
    • (2008) Endocrinology , vol.149 , pp. 950-954
    • Civitarese, A.E.1    Ravussin, E.2
  • 9
    • 0034862983 scopus 로고    scopus 로고
    • Effects of aging β-amyloid on the properties of brain synaptic and mitochondrial membranes
    • Eckert GP, Wood WG, Mueller WE (2001) Effects of aging and beta-amyloid onthe propertiesofbrain synaptic and mito-chondrial membranes. J Neural Transm 108, 1051-1064. (Pubitemid 32802102)
    • (2001) Journal of Neurology , vol.248 , Issue.9 , pp. 1051-1064
    • Eckert, G.P.1    Wood, W.G.2    Muller, W.E.3
  • 10
    • 0034875773 scopus 로고    scopus 로고
    • ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain
    • Leutner S, Eckert A, Mueller WE (2001) ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J Neural Transm 108, 955-967. (Pubitemid 32802093)
    • (2001) Journal of Neurology , vol.248 , Issue.9 , pp. 955-967
    • Leutner, S.1    Eckert, A.2    Muller, W.E.3
  • 11
    • 0000825475 scopus 로고
    • The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria
    • Clayton DA, Doda JN, Friedberg EC (1974) The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci USA 71, 2777-2781.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 2777-2781
    • Clayton, D.A.1    Doda, J.N.2    Friedberg, E.C.3
  • 12
  • 13
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • DOI 10.1038/nature05292, PII NATURE05292
    • Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795. (Pubitemid 44622683)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 14
  • 15
    • 57049143140 scopus 로고    scopus 로고
    • Mitochondria in neuroplasticity and neurological disorders
    • Mattson MP, Gleichmann M, Cheng A (2008) Mitochondria in neuroplasticity and neurological disorders. Neuron 60, 748-766.
    • (2008) Neuron , vol.60 , pp. 748-766
    • Mattson, M.P.1    Gleichmann, M.2    Cheng, A.3
  • 16
    • 35148840090 scopus 로고    scopus 로고
    • Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function - Role of glucose metabolism and insulin signalling
    • DOI 10.1080/13813450701572288, PII 782869494, Proceedings of the 4th Eli Lilly International Foundation Workshop
    • Rhein V, Eckert A (2007) Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function-role of glucose metabolism and insulin signalling. Arch Physiol Biochem 113, 131-141. (Pubitemid 47547386)
    • (2007) Archives of Physiology and Biochemistry , vol.113 , Issue.3 , pp. 131-141
    • Rhein, V.1    Eckert, A.2
  • 17
    • 10944269186 scopus 로고    scopus 로고
    • The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    • DOI 10.1016/j.cell.2004.11.003, PII S0092867404010451
    • Li Z, Okamoto K, Hayashi Y, Sheng M (2004) The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119, 873-887. (Pubitemid 40017692)
    • (2004) Cell , vol.119 , Issue.6 , pp. 873-887
    • Li, Z.1    Okamoto, K.-I.2    Hayashi, Y.3    Sheng, M.4
  • 18
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and alzheimer's disease
    • Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14, 45-53.
    • (2008) Trends Mol Med , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 19
    • 27544484846 scopus 로고    scopus 로고
    • Are mitochondria critical in the pathogenesis of Alzheimer's disease?
    • DOI 10.1016/j.brainresrev.2005.03.004, PII S0165017305000470
    • Reddy PH, Beal MF (2005) Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res Brain Res Rev 49, 618-632. (Pubitemid 41546661)
    • (2005) Brain Research Reviews , vol.49 , Issue.3 , pp. 618-632
    • Reddy, P.H.1    Beal, M.F.2
  • 20
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-Beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 105, 19318-19323.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6    Casadesus, G.7    Zhu, X.8
  • 21
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in alzheimer's disease
    • Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103.
    • (2009) J Neurosci , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6    Zhu, X.7
  • 22
    • 33749854516 scopus 로고    scopus 로고
    • Acute impairment of mitochondrial trafficking by β-amyloid peptides in hippocampal neurons
    • DOI 10.1523/JNEUROSCI.3231-06.2006
    • Rui Y, Tiwari P, Xie Z, Zheng JQ (2006) Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hip-pocampal neurons. J Neurosci 26, 10480-10487. (Pubitemid 44564598)
    • (2006) Journal of Neuroscience , vol.26 , Issue.41 , pp. 10480-10487
    • Rui, Y.1    Tiwari, P.2    Xie, Z.3    Zheng, J.Q.4
  • 24
    • 67649803186 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial structural and functional dynamics in alzheimer's disease
    • Reddy PH (2009) Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol 218, 286-292.
    • (2009) Exp Neurol , vol.218 , pp. 286-292
    • Reddy, P.H.1
  • 25
    • 77955090213 scopus 로고    scopus 로고
    • Abnormal mitochondrial dynamics-a novel therapeutic target for alzheimer's disease?
    • Su B, Wang X, Bonda D, Perry G, Smith M, Zhu X (2010) Abnormal mitochondrial dynamics-a novel therapeutic target for Alzheimer's disease? Mol Neurobiol 41, 87-96.
    • (2010) Mol Neurobiol , vol.41 , pp. 87-96
    • Su, B.1    Wang, X.2    Bonda, D.3    Perry, G.4    Smith, M.5    Zhu, X.6
  • 29
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • DOI 10.1016/S0140-6736(08)61074-0, PII S0140673608610740
    • Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, Seely L, Hung D (2008) Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study. Lancet 372, 207-215. (Pubitemid 351978110)
    • (2008) The Lancet , vol.372 , Issue.9634 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7    Hung, D.8
  • 33
    • 77952387355 scopus 로고    scopus 로고
    • Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or n-methyl-d-aspartate receptor antagonism
    • Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu LR, Cremers T, Altar CA, Wronski R, Hutter-Paier B, Protter AA (2010) Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther 333, 748-757.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 748-757
    • Giorgetti, M.1    Gibbons, J.A.2    Bernales, S.3    Alfaro, I.E.4    Drieu, L.R.5    Cremers, T.6    Altar, C.A.7    Wronski, R.8    Hutter-Paier, B.9    Protter, A.A.10
  • 35
    • 80052559894 scopus 로고    scopus 로고
    • The acute effects of dimebolin, a potential alzheimer's disease treatment, on working memory in rhesus monkeys
    • Webster SJ, Wilson CA, Lee CH, Mohler EG, Terry AV Jr, Buccafusco JJ (2011) The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys. Br J Pharmacol 164, 970-978.
    • (2011) Br J Pharmacol , vol.164 , pp. 970-978
    • Webster, S.J.1    Wilson, C.A.2    Lee, C.H.3    Mohler, E.G.4    Terry Jr., A.V.5    Buccafusco, J.J.6
  • 37
    • 77956666900 scopus 로고    scopus 로고
    • Dimebon disappointment
    • Jones RW (2010) Dimebon disappointment. Alzheimers Res Ther 2, 25.
    • (2010) Alzheimers Res Ther , vol.2 , pp. 25
    • Jones, R.W.1
  • 38
    • 84872210277 scopus 로고    scopus 로고
    • And medivation announce results from phase 3 concert trial of dimebon in alzheimer's disease
    • Medivation, Pfizer Accessed March 13, 2012
    • Medivation, Pfizer And Medivation Announce Results from Phase 3 Concert Trial of Dimebon in Alzheimer's Disease. Dimebon Did Not Meet Primary Efficacy End-points, http://investors.medivation.com/releasedetail.cfm? ReleaseID=639515 Accessed March 13, 2012.
    • Dimebon Did Not Meet Primary Efficacy End-points
  • 39
    • 0035871971 scopus 로고    scopus 로고
    • Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the swedish amyloid precursor protein mutation
    • Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Muller WE (2001) Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. J Neurosci Res 64, 183-192.
    • (2001) J Neurosci Res , vol.64 , pp. 183-192
    • Eckert, A.1    Steiner, B.2    Marques, C.3    Leutz, S.4    Romig, H.5    Haass, C.6    Muller, W.E.7
  • 42
    • 3042781117 scopus 로고    scopus 로고
    • Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
    • DOI 10.1042/BJ20040095
    • Hutter E, Renner K, Pfister G, Stockl P, Jansen-Durr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380, 919-928. (Pubitemid 38850535)
    • (2004) Biochemical Journal , vol.380 , Issue.3 , pp. 919-928
    • Hutter, E.1    Renner, K.2    Pfister, G.3    Stockl, P.4    Jansen-Durr, P.5    Gnaiger, E.6
  • 43
    • 31644443263 scopus 로고    scopus 로고
    • Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β-treated human peritoneal mesothelial cells
    • DOI 10.1385/CBB:44:2:179
    • Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxida-tive phosphorylation but decreased mitochondrial respiratory capacity in IL-1beta-treated human peritoneal mesothelial cells. Cell Biochem Biophys 44, 179-186. (Pubitemid 43172316)
    • (2006) Cell Biochemistry and Biophysics , vol.44 , Issue.2 , pp. 179-186
    • Stadlmann, S.1    Renner, K.2    Pollheimer, J.3    Moser, P.L.4    Zeimet, A.G.5    Offner, F.A.6    Gnaiger, E.7
  • 45
    • 84875460234 scopus 로고    scopus 로고
    • Improved mitochondrial function in brain aging and Alzheimer disease-the new mechanism of action of the old metabolic enhancer piracetam
    • Leuner K, Kurz C, Guidetti G, Orgogozo JM, Muller WE (2010) Improved mitochondrial function in brain aging and Alzheimer disease-the new mechanism of action of the old metabolic enhancer piracetam. Front Neurosci 4, pii 44.
    • (2010) Front Neurosci , vol.4 , pp. 44
    • Leuner, K.1    Kurz, C.2    Guidetti, G.3    Orgogozo, J.M.4    Muller, W.E.5
  • 46
    • 0035112481 scopus 로고    scopus 로고
    • Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • Hood DA (2001) Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90, 1137-1157. (Pubitemid 32171405)
    • (2001) Journal of Applied Physiology , vol.90 , Issue.3 , pp. 1137-1157
    • Hood, D.A.1
  • 48
    • 0017644156 scopus 로고
    • Relation between physiological function and energy metabolism in the central nervous system
    • DOI 10.1111/j.1471-4159.1977.tb03919.x
    • Sokoloff L (1977) Relation between physiological function and energy metabolism in the central nervous system. J Neu-rochem 29, 13-26. (Pubitemid 8150483)
    • (1977) Journal of Neurochemistry , vol.29 , Issue.1 , pp. 13-26
    • Sokoloff, L.1
  • 49
    • 17344368267 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in idiopathic Parkinson disease
    • DOI 10.1086/301812
    • Parker WD Jr, Swerdlow RH (1998) Mitochondrial dysfunction in idiopathic Parkinson disease. Am J Hum Genet 62, 758-762. (Pubitemid 28194314)
    • (1998) American Journal of Human Genetics , vol.62 , Issue.4 , pp. 758-762
    • Parker Jr., W.D.1    Swerdlow, R.H.2
  • 50
    • 33846460819 scopus 로고    scopus 로고
    • Mitochondria mass is low in mouse substantia nigra dopamine neurons: Implications for Parkinson's disease
    • DOI 10.1016/j.expneurol.2006.08.015, PII S0014488606004882
    • Liang CL, Wang TT, Luby-Phelps K, German DC (2007) Mitochondria massis lowinmouse substantia nigra dopamine neurons: Implications for Parkinson's disease. Exp Neurol 203, 370-380. (Pubitemid 46149588)
    • (2007) Experimental Neurology , vol.203 , Issue.2 , pp. 370-380
    • Liang, C.-L.1    Wang, T.T.2    Luby-Phelps, K.3    German, D.C.4
  • 51
    • 0014968409 scopus 로고
    • Mito-chondrial citric acid cycle and related enzymes: Adaptive response to exercise
    • Holloszy JO, Oscai LB, Don IJ, Mole PA (1970) Mito-chondrial citric acid cycle and related enzymes: Adaptive response to exercise. Biochem Biophys Res Commun 40, 1368-1373.
    • (1970) Biochem Biophys Res Commun , vol.40 , pp. 1368-1373
    • Holloszy, J.O.1    Oscai, L.B.2    Don, I.J.3    Mole, P.A.4
  • 52
    • 0022650598 scopus 로고
    • Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle
    • Williams RS, Salmons S, Newsholme EA, Kaufman RE, Mellor J (1986) Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J Biol Chem 261, 376-380. (Pubitemid 16103956)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.1 , pp. 376-380
    • Williams, R.S.1    Salmons, S.2    Newsholme, E.A.3
  • 54
    • 3242887701 scopus 로고    scopus 로고
    • Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons
    • DOI 10.1023/B:BEBM.0000017097.75818.14
    • Grigorev VV, Dranyi OA, Bachurin SO (2003) Comparative study of action mechanisms of dimebon and memantine on AMPA-and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136, 474-477. (Pubitemid 39137308)
    • (2003) Bulletin of Experimental Biology and Medicine , vol.136 , Issue.5 , pp. 474-477
    • Grigor'ev, V.V.1    Dranyi, O.A.2    Bachurin, S.O.3
  • 55
    • 55349083365 scopus 로고    scopus 로고
    • Evaluation of dimebon in cellular model of huntington's disease
    • Wu J, Li Q, Bezprozvanny I (2008) Evaluation of Dimebon in cellular model of Huntington's disease. Mol Neurodegener 3, 15.
    • (2008) Mol Neurodegener , vol.3 , pp. 15
    • Wu, J.1    Li, Q.2    Bezprozvanny, I.3
  • 56
    • 79952707903 scopus 로고    scopus 로고
    • Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release
    • Naga KK, Geddes JW (2011) Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release. Neuromolecular Med 13, 31-36.
    • (2011) Neuromolecular Med , vol.13 , pp. 31-36
    • Naga, K.K.1    Geddes, J.W.2
  • 57
    • 77956214193 scopus 로고    scopus 로고
    • Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death
    • Zhang S, Hedskog L, Petersen CA, Winblad B, Ankarcrona M (2010) Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. J Alzheimers Dis 21, 389-402.
    • (2010) J Alzheimers Dis , vol.21 , pp. 389-402
    • Zhang, S.1    Hedskog, L.2    Petersen, C.A.3    Winblad, B.4    Ankarcrona, M.5
  • 61
    • 79954571354 scopus 로고    scopus 로고
    • The interplay between mitochon-drial dynamics and mitophagy
    • Twig G, Shirihai OS (2011) The interplay between mitochon-drial dynamics and mitophagy. Antioxid Redox Signal 14, 1939-1951.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1939-1951
    • Twig, G.1    Shirihai, O.S.2
  • 62
    • 34547601410 scopus 로고    scopus 로고
    • Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum
    • DOI 10.1016/j.cell.2007.06.026, PII S0092867407007933
    • Chen H, McCaffery JM, Chan DC (2007) Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130, 548-562. (Pubitemid 47198302)
    • (2007) Cell , vol.130 , Issue.3 , pp. 548-562
    • Chen, H.1    McCaffery, J.M.2    Chan, D.C.3
  • 63
    • 77951096150 scopus 로고    scopus 로고
    • Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
    • Chen H, Chan DC (2009) Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 18, R169-R176.
    • (2009) Hum Mol Genet , vol.18
    • Chen, H.1    Chan, D.C.2
  • 65
    • 33751544005 scopus 로고    scopus 로고
    • Mitochondrial dynamics generate equal distribution but patchwork localization of respiratory Complex I
    • DOI 10.1080/09687860600877292, PII K4UR78100K211544
    • Busch KB, Bereiter-Hahn J, Wittig I, Schagger H, Jendrach M (2006) Mitochondrial dynamics generate equal distribution but patchwork localization of respiratory Complex I. Mol Memb Biol 23, 509-520. (Pubitemid 44837736)
    • (2006) Molecular Membrane Biology , vol.23 , Issue.6 , pp. 509-520
    • Busch, K.B.1    Bereiter-Hahn, J.2    Wittig, I.3    Schagger, H.4    Jendrach, M.5
  • 66
    • 0032845895 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain activity in the human brain as a function of age
    • DOI 10.1016/S0047-6374(99)00071-8, PII S0047637499000718
    • Ojaimi J, Masters CL, Opeskin K, McKelvie P, Byrne E (1999) Mitochondrial respiratory chain activity in the human brain as a function of age. Mech Ageing Dev 111, 39-47. (Pubitemid 29486435)
    • (1999) Mechanisms of Ageing and Development , vol.111 , Issue.1 , pp. 39-47
    • Ojaimi, J.1    Masters, C.L.2    Opeskin, K.3    McKelvie, P.4    Byrne, E.5
  • 67
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    • Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324, 102-105.
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3    Cieplak, P.4    Godzik, A.5    Gu, Z.6    Lipton, S.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.