-
1
-
-
72149097863
-
Guide to Receptors and Channels (GRAC) 4th edition
-
(Suppl.).
-
Alexander SP, Mathie A, Peters JA, (2009). Guide to Receptors and Channels (GRAC) 4th edition. Br J Pharmacol 158 (Suppl. 1): S1-S254.
-
(2009)
Br J Pharmacol
, vol.158
, Issue.1
-
-
Alexander, S.P.1
Mathie, A.2
Peters, J.A.3
-
2
-
-
0034944798
-
Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer
-
Bachurin S, Bukatina E, Lermontova N, Tkachenko S, Afanasiev A, Grigoriev V, et al,. (2001). Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer. Ann NY Acad Sci 939: 425-435. (Pubitemid 32620096)
-
(2001)
Annals of the New York Academy of Sciences
, vol.939
, pp. 425-435
-
-
Bachurin, S.1
Bukatina, E.2
Lermontova, N.3
Tkachenko, S.4
Afanasiev, A.5
Grigoriev, V.6
Grigorieva, I.7
Ivanov, Yu.8
Sablin, S.9
Zefirov, N.10
-
3
-
-
0037713338
-
Mitochondria as a target for neurotoxins and neuroprotective agents
-
Bachurin SO, Shevtsova EP, Kireeva EG, Oxenkrug GF, Sablin SO, (2003). Mitochondria as a target for neurotoxins and neuroprotective agents. Ann NY Acad Sci 993: 334-344. discussion 345-9. (Pubitemid 36808462)
-
(2003)
Annals of the New York Academy of Sciences
, vol.993
, pp. 334-344
-
-
Bachurin, S.O.1
Shevtsova, E.P.2
Kireeva, E.G.3
Oxenkrug, G.F.4
Sablin, S.O.5
-
4
-
-
0032763708
-
Effect of rivastigmine on scopolamine-induced memory impairment in rats
-
Bejar C, Wang RH, Weinstock M, (1999). Effect of rivastigmine on scopolamine-induced memory impairment in rats. Eur J Pharmacol 383: 231-240.
-
(1999)
Eur J Pharmacol
, vol.383
, pp. 231-240
-
-
Bejar, C.1
Wang, R.H.2
Weinstock, M.3
-
5
-
-
42749100518
-
Cholinesterase inhibitors for Alzheimer's disease
-
Birks J, (2006). Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev (1): CD005593.
-
(2006)
Cochrane Database Syst Rev
, Issue.1
-
-
Birks, J.1
-
6
-
-
34249697099
-
-
Johns Hopkins University Johns Hopkins University, Dept. of Biostatistics Working Papers
-
Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi MH, (2007). Forecasting the global burden of Alzheimer's disease. Johns Hopkins University Johns Hopkins University, Dept. of Biostatistics Working Papers, page 130.
-
(2007)
Forecasting the Global Burden of Alzheimer's Disease
, pp. 130
-
-
Brookmeyer, R.1
Johnson, E.2
Ziegler-Graham, K.3
Arrighi, M.H.4
-
7
-
-
33751089073
-
Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: Deficits induced by scopolamine and by prolonging the retention interval
-
DOI 10.1016/j.pbb.2006.08.007, PII S0091305706002644
-
de Bruin N, Pouzet B, (2006). Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: deficits induced by scopolamine and by prolonging the retention interval. Pharmacol Biochem Behav 85: 253-260. (Pubitemid 44772926)
-
(2006)
Pharmacology Biochemistry and Behavior
, vol.85
, Issue.1
, pp. 253-260
-
-
De Bruin, N.1
Pouzet, B.2
-
8
-
-
58149385516
-
Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders
-
Buccafusco JJ, (2008). Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders. J Alzheimers Dis 15: 709-720.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 709-720
-
-
Buccafusco, J.J.1
-
9
-
-
46649086754
-
The scopolamine-reversal paradigm in rats and monkeys: The importance of computer-assisted operant-conditioning memory tasks for screening drug candidates
-
DOI 10.1007/s00213-007-0887-8
-
Buccafusco JJ, Terry Jr. AV, Webster SJ, Martin DM, Hohnadel EJ, Bouchard KA, et al,. (2008). The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant conditioning memory tasks for screening drug candidates. Psychopharmacology 199: 481-494. (Pubitemid 351938233)
-
(2008)
Psychopharmacology
, vol.199
, Issue.3
, pp. 481-494
-
-
Buccafusco, J.J.1
Terry Jr., A.V.2
Webster, S.J.3
Martin, D.4
Hohnadel, E.J.5
Bouchard, K.A.6
Warner, S.E.7
-
10
-
-
59449088302
-
Protracted cognitive effects produced by clonidine in Macaca Nemestrina performing a delayed matching task
-
Buccafusco JJ, Webster SJ, Terry Jr. AV, Kille N, Blessing D, (2009). Protracted cognitive effects produced by clonidine in Macaca Nemestrina performing a delayed matching task. Psychopharmacology 202: 477-485.
-
(2009)
Psychopharmacology
, vol.202
, pp. 477-485
-
-
Buccafusco, J.J.1
Webster, S.J.2
Terry Jr., A.V.3
Kille, N.4
Blessing, D.5
-
11
-
-
54249114011
-
Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: Future directions
-
Carlsson CM, (2008). Lessons learned from failed and discontinued clinical trials for the treatment of Alzheimer's disease: future directions. J Alzheimers Dis 15: 327-338.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 327-338
-
-
Carlsson, C.M.1
-
12
-
-
3042857903
-
Alzheimer's disease
-
Cummings JL, (2004). Alzheimer's disease. N Engl J Med 351: 56-67.
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
13
-
-
47149108940
-
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
DOI 10.1016/S0140-6736(08)61074-0, PII S0140673608610740
-
Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, et al,. (2008). Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 372: 207-215. (Pubitemid 351978110)
-
(2008)
The Lancet
, vol.372
, Issue.9634
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
Thomas, R.G.4
Aisen, P.S.5
Bachurin, S.O.6
Seely, L.7
Hung, D.8
-
14
-
-
0022384940
-
Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats
-
DOI 10.1007/BF00432721
-
Dunnett SB, (1985). Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats. Psychopharmacology (Berl) 87: 357-363. (Pubitemid 16225687)
-
(1985)
Psychopharmacology
, vol.87
, Issue.3
, pp. 357-363
-
-
Dunnett, S.B.1
-
15
-
-
0031744035
-
Scopolamine model of dementia: Electroencephalogram findings and cognitive performance
-
DOI 10.1046/j.1365-2362.1998.00393.x
-
Ebert U, Kirch W, (1998). Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Invest 28: 944-949. (Pubitemid 28521587)
-
(1998)
European Journal of Clinical Investigation
, vol.28
, Issue.11
, pp. 944-949
-
-
Ebert, U.1
Kirch, W.2
-
16
-
-
84958342973
-
Chance ordering of alternating stimuli in visual discrimination
-
Gellerman E, (1933). Chance ordering of alternating stimuli in visual discrimination. Pedagog Sem J Genetic Psychol 42: 206-208.
-
(1933)
Pedagog Sem J Genetic Psychol
, vol.42
, pp. 206-208
-
-
Gellerman, E.1
-
17
-
-
77952387355
-
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
-
Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu La Rochelle C, Cremers T, et al,. (2010). Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther 333: 748-757.
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 748-757
-
-
Giorgetti, M.1
Gibbons, J.A.2
Bernales, S.3
Alfaro, I.E.4
Drieu La Rochelle, C.5
Cremers, T.6
-
18
-
-
3242887701
-
Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons
-
DOI 10.1023/B:BEBM.0000017097.75818.14
-
Grigorev VV, Dranyi OA, Bachurin SO, (2003). Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136: 474-477. (Pubitemid 39137308)
-
(2003)
Bulletin of Experimental Biology and Medicine
, vol.136
, Issue.5
, pp. 474-477
-
-
Grigor'ev, V.V.1
Dranyi, O.A.2
Bachurin, S.O.3
-
19
-
-
64349108940
-
Effects of chronic administration of dimebon on behavior and memory of SAMP 10 mice
-
Grigor'ev VV, Garibova TL, Voronina TA, Litvinova SA, Bachurin SO, (2009). [Effects of chronic administration of dimebon on behavior and memory of SAMP 10 mice]. Eksp Klin Farmakol 72: 52-56.
-
(2009)
Eksp Klin Farmakol
, vol.72
, pp. 52-56
-
-
Grigor'Ev, V.V.1
Garibova, T.L.2
Voronina, T.A.3
Litvinova, S.A.4
Bachurin, S.O.5
-
20
-
-
0025783827
-
Clonidine enhances delayed matching-to-sample performance by young and aged monkeys
-
Jackson WJ, Buccafusco JJ, (1991). Clonidine enhances delayed matching-to-sample performance by young and aged monkeys. Pharmacol Biochem Behav 39: 79-84.
-
(1991)
Pharmacol Biochem Behav
, vol.39
, pp. 79-84
-
-
Jackson, W.J.1
Buccafusco, J.J.2
-
21
-
-
76149084493
-
A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease
-
Dimebon in Subjects With Huntington Disease (DIMOND) Investigators of the Huntington Study Group.
-
Kieburtz K, McDermott MP, Voss TS, Corey-Bloom J, Deuel LM, Dorsey ER, et al,. Dimebon in Subjects With Huntington Disease (DIMOND) Investigators of the Huntington Study Group (2010). A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease. Arch Neurol 67: 154-160.
-
(2010)
Arch Neurol
, vol.67
, pp. 154-160
-
-
Kieburtz, K.1
McDermott, M.P.2
Voss, T.S.3
Corey-Bloom, J.4
Deuel, L.M.5
Dorsey, E.R.6
-
22
-
-
0033635668
-
Dimebon improves learning in animals with experimental Alzheimer's disease
-
Lermontova NN, Lukoyanov NV, Serkova TP, Lukoyanova EA, Bachurin SO, (2000). Dimebon improves learning in animals with experimental Alzheimer's disease. Bull Exp Biol Med 129: 544-546.
-
(2000)
Bull Exp Biol Med
, vol.129
, pp. 544-546
-
-
Lermontova, N.N.1
Lukoyanov, N.V.2
Serkova, T.P.3
Lukoyanova, E.A.4
Bachurin, S.O.5
-
23
-
-
0036218369
-
2+ channels
-
Lermontova NN, Redkozubov AE, Shevtsova EF, Serkova TP, Kireeva EG, Bachurin SO, (2001). Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels. Bull Exp Biol Med 132: 1079-1083. (Pubitemid 34295938)
-
(2001)
Bulletin of Experimental Biology and Medicine
, vol.132
, Issue.5
, pp. 1079-1083
-
-
Lermontova, N.N.1
Redkozubov, A.E.2
Shevtsova, E.F.3
Serkova, T.P.4
Kireeva, E.G.5
Bachurin, S.O.6
-
24
-
-
34248525381
-
Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping
-
DOI 10.1007/s00213-006-0556-3
-
Lindner MD, Hogan JB, Hodges DB Jr, Orie AF, Chen P, Corsa JA, et al,. (2006). Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping. Psychopharmacology (Berl) 188: 629-640. (Pubitemid 46758973)
-
(2006)
Psychopharmacology
, vol.188
, Issue.4
, pp. 629-640
-
-
Lindner, M.D.1
Hogan, J.B.2
Hodges Jr., D.B.3
Orie, A.F.4
Chen, P.5
Corsa, J.A.6
Leet, J.E.7
Gillman, K.W.8
Rose, G.M.9
Jones, K.M.10
Gribkoff, V.K.11
-
25
-
-
73449115350
-
Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?
-
Lowenstein PR, Castro MG, (2009). Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail? Curr Gene Ther 9: 368-374.
-
(2009)
Curr Gene Ther
, vol.9
, pp. 368-374
-
-
Lowenstein, P.R.1
Castro, M.G.2
-
26
-
-
77954115000
-
Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials
-
McArthur RA, Gray J, Schreiber R, (2010). Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs 11: 740-760.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 740-760
-
-
McArthur, R.A.1
Gray, J.2
Schreiber, R.3
-
27
-
-
0031770363
-
Symposium overview: The use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans
-
DOI 10.1016/S0892-0362(98)00013-0, PII S0892036298000130
-
Paule MG, Bushnell PJ, Maurissen JP, Wenger GR, Buccafusco JJ, Chelonis JJ, et al,. (1998). Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans. Neurotoxicol Teratol 20: 493-502. (Pubitemid 28511113)
-
(1998)
Neurotoxicology and Teratology
, vol.20
, Issue.5
, pp. 493-502
-
-
Paule, M.G.1
Bushnell, P.J.2
Maurissen, J.P.J.3
Wenger, G.R.4
Buccafusco, J.J.5
Chelonis, J.J.6
Elliott, R.7
-
29
-
-
69349100072
-
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities
-
Schaffhauser H, Mathiasen JR, Dicamillo A, Huffman MJ, Lu LD, McKenna BA, et al,. (2009). Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. Biochem Pharmacol 78: 1035-1042.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 1035-1042
-
-
Schaffhauser, H.1
Mathiasen, J.R.2
Dicamillo, A.3
Huffman, M.J.4
Lu, L.D.5
McKenna, B.A.6
-
30
-
-
0025226511
-
A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice
-
Shannon HE, Peters SC, (1990). A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. J Pharmacol Exp Ther 255: 549-553.
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 549-553
-
-
Shannon, H.E.1
Peters, S.C.2
-
31
-
-
56949087846
-
Lost in translation: Problems and pitfalls in translating laboratory observations to clinical utility
-
Simon R, (2008). Lost in translation: problems and pitfalls in translating laboratory observations to clinical utility. Eur J Cancer 44: 2707-2713.
-
(2008)
Eur J Cancer
, vol.44
, pp. 2707-2713
-
-
Simon, R.1
-
32
-
-
4944254557
-
Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats
-
DOI 10.1016/j.bbr.2004.05.010, PII S0166432804001780
-
van der Staay FJ, Bouger PC, (2005). Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats. Behav Brain Res 156: 1-10. (Pubitemid 39330431)
-
(2005)
Behavioural Brain Research
, vol.156
, Issue.1
, pp. 1-10
-
-
Van Der Staay, F.J.1
Bouger, P.C.2
-
33
-
-
0036020324
-
1-preferring agonist, talsaclidine
-
DOI 10.1007/s00213-002-1105-3
-
Terry AV Jr, Buccafusco JJ, Borsini F, Leusch A, (2002). Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine. Psychopharmacology (Berl) 162: 292-300. Epub 2002 May 29. (Pubitemid 34762288)
-
(2002)
Psychopharmacology
, vol.162
, Issue.3
, pp. 292-300
-
-
Terry, A.V.1
Buccafusco, J.J.2
Borsini, F.3
Leusch, A.4
-
34
-
-
74549195970
-
Experimental Study of Dimebon Kinetics
-
All-Union Scientific-Research Institute of Biotechnology, Moscow December, 1991. Original article submitted December 12, 1990
-
Tishchenkova IF, Agapitova IV, Dorokhov VV, Bobroy VI, Dubrovina LYU, (1991). Experimental Study of Dimebon Kinetics. All-Union Scientific-Research Institute of Biotechnology, Moscow. Translated from Khimii-farmatsevticheskii Zhurnal, Vol. 25, No. 12, pp.13-15, December, 1991. Original article submitted December 12, 1990.
-
(1991)
Translated from Khimii-farmatsevticheskii Zhurnal
, vol.25
, Issue.12
, pp. 13-15
-
-
Tishchenkova, I.F.1
Agapitova, I.V.2
Dorokhov, V.V.3
Bobroy, V.I.4
Dubrovina, L.Y.U.5
-
36
-
-
55349083365
-
Evaluation of Dimebon in cellularmodel ofHuntington's disease
-
Wu J, Li Q, Bezprozvanny I, (2008). Evaluation of Dimebon in cellularmodel ofHuntington's disease. Mol Neurodegener 3: 15.
-
(2008)
Mol Neurodegener
, vol.3
, pp. 15
-
-
Wu, J.1
Li, Q.2
Bezprozvanny, I.3
-
37
-
-
17644375125
-
CNS Targets for multi-functional drugs in the treatment of Alzheimer's and Parkinson's diseases
-
DOI 10.1007/s00702-004-0214-z
-
Youdim MBH, Buccafusco JJ, (2005a). CNS targets for multi-functional drugs in the treatment of neurodegenerative diseases. J Neural Transm 112: 519-537. (Pubitemid 40562085)
-
(2005)
Journal of Neural Transmission
, vol.112
, Issue.4
, pp. 519-537
-
-
Youdim, M.B.H.1
Buccafusco, J.J.2
-
38
-
-
11144245220
-
Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
-
DOI 10.1016/j.tips.2004.11.007, PII S016561470400313X
-
Youdim MBH, Buccafusco JJ, (2005b). Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacological Sci 26: 27-35. (Pubitemid 40052707)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.1
, pp. 27-35
-
-
Youdim, M.B.H.1
Buccafusco, J.J.2
|