-
1
-
-
38449116472
-
Dimebolin hydrochloride
-
Molecule of the month.
-
Molecule of the month. Dimebolin hydrochloride. Drug News Perspect 2007;20:467.
-
(2007)
Drug News Perspect
, vol.20
, pp. 467
-
-
-
2
-
-
47149116336
-
Dimebon in Alzheimer's disease: Old drug for new indication
-
Burns A, Jacoby R. Dimebon in Alzheimer's disease: Old drug for new indication. Lancet 2008;372:179-180.
-
(2008)
Lancet
, vol.372
, pp. 179-180
-
-
Burns, A.1
Jacoby, R.2
-
3
-
-
47149108940
-
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
-
Doody RS, Gavrilova SI, Sano M, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study. Lancet 2008;372:207-215.
-
(2008)
Lancet
, vol.372
, pp. 207-215
-
-
Doody, R.S.1
Gavrilova, S.I.2
Sano, M.3
-
4
-
-
61849157257
-
Alzheimer's disease
-
Burns A, Iliffe S. Alzheimer's disease. BMJ 2009;338:179-180.
-
(2009)
BMJ
, vol.338
, pp. 179-180
-
-
Burns, A.1
Iliffe, S.2
-
5
-
-
79955707221
-
-
Alzheimer's Society 2007, Dementia UK report, London [Accessed March 30, 2010.
-
Alzheimer's Society 2007, Dementia UK report, London 2007. [Accessed March 30, 2010.
-
(2007)
-
-
-
6
-
-
75149173859
-
Neuropathological Correlates of Dementia in Over-80-Year-Old Brain Donors from the Population-Based Cambridge City over-75s Cohort (CC75C) Study
-
Brayne C, Richardson K, Matthews FE, et al. Neuropathological Correlates of Dementia in Over-80-Year-Old Brain Donors from the Population-Based Cambridge City over-75s Cohort (CC75C) Study. J Alzheimers Dis 2009;18:645-658.
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 645-658
-
-
Brayne, C.1
Richardson, K.2
Matthews, F.E.3
-
7
-
-
33644942362
-
Quantification of Alzheimer pathology in ageing and dementia: Age-related accumulation of amyloid-beta(42) peptide in vascular dementia
-
Lewis H, Beher D, Cookson N, et al. Quantification of Alzheimer pathology in ageing and dementia: Age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathol Appl Neurobiol 2006;32:103-118.
-
(2006)
Neuropathol Appl Neurobiol
, vol.32
, pp. 103-118
-
-
Lewis, H.1
Beher, D.2
Cookson, N.3
-
8
-
-
0031054674
-
Brain infarction and the clinical expression of Alzheimer disease
-
Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813-817.
-
(1997)
The Nun Study. JAMA
, vol.277
, pp. 813-817
-
-
Snowdon, D.A.1
Greiner, L.H.2
Mortimer, J.A.3
Riley, K.P.4
Greiner, P.A.5
Markesbery, W.R.6
-
9
-
-
33646184840
-
The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies
-
Sahin HA, Emre M, Ziabreva I, Perry E, Celasun B, Perry R. The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol 2006;111:115-125.
-
(2006)
Acta Neuropathol
, vol.111
, pp. 115-125
-
-
Sahin, H.A.1
Emre, M.2
Ziabreva, I.3
Perry, E.4
Celasun, B.5
Perry, R.6
-
10
-
-
0028873975
-
Neurochemical correlates of dementia severity in Alzheimer's disease: Relative importance of the cholinergic deficits
-
Bierer LM, Haroutunian V, Gabriel S, et al. Neurochemical correlates of dementia severity in Alzheimer's disease: Relative importance of the cholinergic deficits. J Neurochem 1995;64:749-760.
-
(1995)
J Neurochem
, vol.64
, pp. 749-760
-
-
Bierer, L.M.1
Haroutunian, V.2
Gabriel, S.3
-
12
-
-
79955722868
-
National Institute for Health and Clinical Excellence
-
Technology appraisals TA111. London NICE. 2007. [Accessed March 30, 2010.
-
National Institute for Health and Clinical Excellence 2007, Alzheimer's disease-donepezil, galantamine, rivastigmine (review) and memantine. Technology appraisals TA111. London NICE. 2007. [Accessed March 30, 2010.
-
(2007)
Alzheimer's disease-donepezil, galantamine, rivastigmine (review) and memantine
-
-
-
13
-
-
41049111771
-
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline
-
Raina P, Santaguida P, Ismaila A, et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline. Ann Intern Med 2008;148:379-397.
-
(2008)
Ann Intern Med
, vol.148
, pp. 379-397
-
-
Raina, P.1
Santaguida, P.2
Ismaila, A.3
-
14
-
-
4344665066
-
Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: A review based on meta-analyses by the cochrane collaboration
-
Kurz A, Van Baelen B. Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: A review based on meta-analyses by the cochrane collaboration. Dement Geriatr Cogn Disord 2004;18:217-226.
-
(2004)
Dement Geriatr Cogn Disord
, vol.18
, pp. 217-226
-
-
Kurz, A.1
Van Baelen, B.2
-
15
-
-
0036163534
-
The effect of selegiline in the treatment of people with Alzheimer's disease: A meta-analysis of published trials
-
Wilcock GK, Birks J, Whitehead A, Evans SJ. The effect of selegiline in the treatment of people with Alzheimer's disease: A meta-analysis of published trials. Int J Geriatr Psychiatry 2002;17:175-183.
-
(2002)
Int J Geriatr Psychiatry
, vol.17
, pp. 175-183
-
-
Wilcock, G.K.1
Birks, J.2
Whitehead, A.3
Evans, S.J.4
-
16
-
-
0141483376
-
Current treatment for Alzheimer disease and future prospects
-
Tariot PN, Federoff HJ. Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord 2003;17(Suppl 4):S105-S113.
-
(2003)
Alzheimer Dis Assoc Disord
, vol.17
, Issue.SUPPL. 4
-
-
Tariot, P.N.1
Federoff, H.J.2
-
17
-
-
0030967165
-
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease Cooperative Study
-
Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's disease Cooperative Study. N Engl J Med 1997;336:1216-1222.
-
(1997)
N Engl J Med
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
-
18
-
-
0020643057
-
Action of dimebon on histamine receptors
-
Matveeva IA. Action of dimebon on histamine receptors. Farmakol Toksikol 1983;46:27-29.
-
(1983)
Farmakol Toksikol
, vol.46
, pp. 27-29
-
-
Matveeva, I.A.1
-
20
-
-
0033635668
-
Dimebon improves learning in animals with experimental Alzheimer's disease
-
Lermontova NN, Lukoyanov NV, Serkova TP, Lukoyanova EA, Bachurin SO. Dimebon improves learning in animals with experimental Alzheimer's disease. Bull Exp Biol Med 2000;129:544-546.
-
(2000)
Bull Exp Biol Med
, vol.129
, pp. 544-546
-
-
Lermontova, N.N.1
Lukoyanov, N.V.2
Serkova, T.P.3
Lukoyanova, E.A.4
Bachurin, S.O.5
-
21
-
-
0034944798
-
Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer
-
Bachurin S, Bukatina E, Lermontova N, et al. Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 2001;939:425-435.
-
(2001)
Ann N Y Acad Sci
, vol.939
, pp. 425-435
-
-
Bachurin, S.1
Bukatina, E.2
Lermontova, N.3
-
22
-
-
0036218369
-
Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels
-
Lermontova NN, Redkozubov AE, Shevtsova EF, Serkova TP, Kireeva EG, Bachurin SO. Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels. Bull Exp Biol Med 2001;132:1079-1083.
-
(2001)
Bull Exp Biol Med
, vol.132
, pp. 1079-1083
-
-
Lermontova, N.N.1
Redkozubov, A.E.2
Shevtsova, E.F.3
Serkova, T.P.4
Kireeva, E.G.5
Bachurin, S.O.6
-
23
-
-
0037713338
-
Mitochondria as a target for neurotoxins and neuroprotective agents
-
discussion 345-349.
-
Bachurin SO, Shevtsova EP, Kireeva EG, Oxenkrug GF, Sablin SO. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 2003;993:334-344; discussion 345-349.
-
(2003)
Ann N Y Acad Sci
, vol.993
, pp. 334-344
-
-
Bachurin, S.O.1
Shevtsova, E.P.2
Kireeva, E.G.3
Oxenkrug, G.F.4
Sablin, S.O.5
-
24
-
-
3242887701
-
Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons
-
Grigorev VV, Dranyi OA, Bachurin SO. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 2003;136:474-477.
-
(2003)
Bull Exp Biol Med
, vol.136
, pp. 474-477
-
-
Grigorev, V.V.1
Dranyi, O.A.2
Bachurin, S.O.3
-
25
-
-
55349083365
-
Evaluation of Dimebon in cellular model of Huntington's disease
-
Wu J, Li Q, Bezprozvanny I. Evaluation of Dimebon in cellular model of Huntington's disease. Mol Neurodegener 2008;3:15, doi:.
-
(2008)
Mol Neurodegener
, vol.3
, pp. 15
-
-
Wu, J.1
Li, Q.2
Bezprozvanny, I.3
-
26
-
-
69349100072
-
Dimebolin is a 5-HT(6) antagonist with acute cognition enhancing activities
-
Schaffhauser H, Mathiasen JR, Dicamillo A, et al. Dimebolin is a 5-HT(6) antagonist with acute cognition enhancing activities. Biochem Pharmacol 2009;78:1035-1042.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 1035-1042
-
-
Schaffhauser, H.1
Mathiasen, J.R.2
Dicamillo, A.3
-
27
-
-
65749088098
-
Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists
-
Ivachtchenko AV, Frolov EB, Mitkin OD, et al. Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. Bioorg Med Chem Lett 2009;19:3183-3187.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 3183-3187
-
-
Ivachtchenko, A.V.1
Frolov, E.B.2
Mitkin, O.D.3
-
28
-
-
79955712148
-
-
ICAD Vienna Presentation
-
Gandy S, Cirrito J, Steele J, et al. A clinically promising drug for Alzheimer disease, regulates amyloid-beta metabolism in cultured cells, in isolated nerve terminals, and in the interstitial fluid of the living rodent brain. ICAD 2009 Vienna Presentation #: S4-04-06.
-
(2009)
A clinically promising drug for Alzheimer disease, regulates amyloid-beta metabolism in cultured cells, in isolated nerve terminals, and in the interstitial fluid of the living rodent brain
-
-
Gandy, S.1
Cirrito, J.2
Steele, J.3
-
29
-
-
67650140610
-
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
-
Yamashita M, Nonaka T, Arai T, et al. Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. FEBS Lett 2009;583:2419-2424.
-
(2009)
FEBS Lett
, vol.583
, pp. 2419-2424
-
-
Yamashita, M.1
Nonaka, T.2
Arai, T.3
-
30
-
-
79955716997
-
-
ICAD Submitted Abstract #P1-254. A safety, tolerability and pharmacokinetic study of dimebon in patients with Alzheimer's disease already receiving donepezil. Poster Session. July 12, 2009: 12:30-3:00 p.m. P Tariot - Presenter. 2009 International Conference on Alzheimer's Disease (ICAD), Vienna, Austria July
-
ICAD Submitted Abstract #P1-254. A safety, tolerability and pharmacokinetic study of dimebon in patients with Alzheimer's disease already receiving donepezil. Poster Session. July 12, 2009: 12:30-3:00 p.m. P Tariot - Presenter. 2009 International Conference on Alzheimer's Disease (ICAD), Vienna, Austria July 2009;11-160.
-
(2009)
, pp. 11-160
-
-
-
33
-
-
76249083708
-
Acute dosing of latrepirdine (DimebonTM), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo
-
Steele JW, Kim SH, Cirrito JR, et al. Acute dosing of latrepirdine (DimebonTM), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Mol Neurodegener 2009;4:51.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 51
-
-
Steele, J.W.1
Kim, S.H.2
Cirrito, J.R.3
-
34
-
-
0022066229
-
Preclinical study of the safety of the antihistaminic preparation dimebon
-
Golubeva MI, Shashkina LF, Proǐnova VA, Fedorova EA, Nechushkina LV. Preclinical study of the safety of the antihistaminic preparation dimebon. Farmakol Toksikol 1985;48:114-119.
-
(1985)
Farmakol Toksikol
, vol.48
, pp. 114-119
-
-
Golubeva, M.I.1
Shashkina, L.F.2
Proǐnova, V.A.3
Fedorova, E.A.4
Nechushkina, L.V.5
-
35
-
-
34249654120
-
Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine
-
Roegge CS, Perraut C, Hao X, Levin ED. Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. Pharmacol Biochem Behav 2007;86:686-692.
-
(2007)
Pharmacol Biochem Behav
, vol.86
, pp. 686-692
-
-
Roegge, C.S.1
Perraut, C.2
Hao, X.3
Levin, E.D.4
-
36
-
-
34249943972
-
Role of hippocampal H1 receptors in radial maze performance and hippocampal theta activity in rats
-
Masuoka T, Kamei C. Role of hippocampal H1 receptors in radial maze performance and hippocampal theta activity in rats. Brain Res Bull 2007;73:231-237.
-
(2007)
Brain Res Bull
, vol.73
, pp. 231-237
-
-
Masuoka, T.1
Kamei, C.2
|